General Information of the Protein
Protein ID
PT02677
Protein Name
B1 bradykinin receptor
Secondarily
Protein Name
Kinin B1 receptor
Gene Name
BDKRB1
Secondarily
Gene Name
B1bkr
Bkr
Sequence
MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVITICFFGLLGNLLVLSFFLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPFWAENIGNRFNWPFGTDLCRVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRRRRQAQATCLLIWVAGGLLSIPTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNVLGFLLPVTAIIFFNYHILASLRGQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPYHFFAFLDFLVQVRVIQDCSWKEITDLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVLGTL
    Show/Hide
Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Bradykinin receptor
Function
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
    Show/Hide
Uniprot ID
Primary ID:
P97583

Secondarily ID:
O35782
Q9R250
    Show/Hide
Ensembl ID
ENSG00000100739
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0285467
 Compound Info 
(R)-N-((R)-1-(5-(5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)-3-fluoropyridin-2-yl)ethyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
   Show/Hide
C20H16ClF5N4O3
  1
1
Ki = 2.18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0133227
 Compound Info 
N-[4-chloro-2-[[(1R)-1-[4-[3-fluoro-2-(1-methyltetrazol-5-yl)phenyl]phenyl]ethyl]amino]pyridin-3-yl]-2-cyanoacetamide
   Show/Hide
C24H20ClFN8O
  1
1
Ki = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0104189
 Compound Info 
4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamino)-pyridin-2-ylamino]-ethyl}-3-fluoro-biphenyl-2-carboxylic acid methyl ester
   Show/Hide
C24H20ClFN4O3
  1
1
Ki = 35.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0038994
 Compound Info 
3-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamino)-pyridin-2-ylamino]-ethyl}-biphenyl-2-carboxylic acid methyl ester
   Show/Hide
C24H20Cl2N4O3
  1
1
Ki = 35.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0340549
 Compound Info 
N-[4-chloro-2-[[(1R)-1-[4-[3-fluoro-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]phenyl]ethyl]amino]pyridin-3-yl]-2-cyanoacetamide
   Show/Hide
C25H20ClFN6O2
  1
1
Ki = 81 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0369234
 Compound Info 
N-[4-chloro-2-[[(1R)-1-[4-[3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]phenyl]ethyl]amino]pyridin-3-yl]-2-cyanoacetamide
   Show/Hide
C24H20ClFN8O
  1
1
Ki = 119 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01986 B1 bradykinin receptor Oryctolagus cuniculus, Rabbit
 Protein Info 
PT05747 B1 bradykinin receptor Canis lupus familiaris, Dog, Canis familiaris
 Protein Info