General Information of the Protein
| Protein ID |
PT02563
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| Protein Name |
Methylated-DNA--protein-cysteine methyltransferase
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| Secondarily Protein Name |
6-O-methylguanine-DNA methyltransferase
O-6-methylguanine-DNA-alkyltransferase
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| Gene Name |
MGMT
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| Sequence |
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPGLGGSSGLAGAWLKGAGATSGSPPAGRN
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| Organism |
Homo sapiens, Human
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| Protein Classification |
Enzyme
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| Function |
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
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| Uniprot ID |
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| Subcellular Location |
Nucleus
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000174 , Raji
Biochemical Assays
Clinical Information about the Protein
Target 1 ( O-6-methylguanine-DNA-alkyltransferase (MGMT) )
| Target Type | Clinical trial Target | ||||
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