General Information of the Protein
Protein ID
PT02538
Protein Name
Retinoic acid receptor RXR-beta
Secondarily
Protein Name
MHC class I regulatory element-binding protein H-2RIIBP
Nuclear receptor subfamily 2 group B member 2
Retinoid X receptor beta
Gene Name
RXRB
Secondarily
Gene Name
Nr2b2
Sequence
MSWATRPPFLPPRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAGEQQALEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLSQGIRPSSPPGPPLTPSAPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGATGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
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Organism
Mus musculus, Mouse
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 2
>
Nuclear hormone receptor subfamily 2 group B
>
Nuclear hormone receptor subfamily 2 group B member 2
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
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Uniprot ID
Primary ID:
P28704

Secondarily ID:
P33243
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Ensembl ID
ENSG00000204231
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0756593
 Compound Info 
3-Methyl-5-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-bicyclo[3.1.0]hex-1-yl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 3 nM
 Bioactivity Info 
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CP0042976
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
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C24H32O2
  1
1
EC50 = 6 nM
 Bioactivity Info 
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CP0122733
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 9 nM
 Bioactivity Info 
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CP0135295
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 10 nM
 Bioactivity Info 
   TI
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CP0059698
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 14 nM
 Bioactivity Info 
   TI
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   LO
   TS
CP0042888
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-hexa-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 19 nM
 Bioactivity Info 
   TI
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CP0063990
 Compound Info 
(2E,4E)-6-[1-(3,5-Di-tert-butyl-phenyl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
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C24H34O2
  1
1
EC50 = 19 nM
 Bioactivity Info 
   TI
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CP0105557
 Compound Info 
(2E,4E)-6-[1-(6-tert-Butyl-1,1-dimethyl-indan-4-yl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 22 nM
 Bioactivity Info 
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CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
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C24H28O2
  2
1
EC50 = 24 nM
 Bioactivity Info 
   TI
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2
EC50 = 25 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0109273
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 29 nM
 Bioactivity Info 
   TI
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   LO
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CP0111163
 Compound Info 
4-[1-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25ClO2
  1
1
EC50 = 33 nM
 Bioactivity Info 
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CP0059678
 Compound Info 
3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C25H32O2
  1
1
EC50 = 42 nM
 Bioactivity Info 
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CP0063958
 Compound Info 
4-[1-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25BrO2
  1
1
EC50 = 59 nM
 Bioactivity Info 
   TI
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CP0044733
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 62 nM
 Bioactivity Info 
   TI
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CP0186182
 Compound Info 
4-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23BrO3
  1
1
EC50 = 120 nM
 Bioactivity Info 
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CP0042977
 Compound Info 
9-cis retinoic acid
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C20H28O2
  1
1
EC50 = 128 nM
 Bioactivity Info 
   TI
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CP0149955
 Compound Info 
4-[1-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C25H30O2
  1
1
EC50 = 145 nM
 Bioactivity Info 
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CP0149843
 Compound Info 
4-[1-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25FO2
  1
1
EC50 = 189 nM
 Bioactivity Info 
   TI
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   LO
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CP0277989
 Compound Info 
3-Methyl-5-[2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 191 nM
 Bioactivity Info 
   TI
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CP0105911
 Compound Info 
4-[1-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C24H28O3
  1
1
EC50 = 198 nM
 Bioactivity Info 
   TI
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CP0100503
 Compound Info 
4-[1-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O3
  1
1
EC50 = 202 nM
 Bioactivity Info 
   TI
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CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O3
  1
1
EC50 = 213 nM
 Bioactivity Info 
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CP0267152
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 220 nM
 Bioactivity Info 
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CP0102521
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 222 nM
 Bioactivity Info 
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CP0144133
 Compound Info 
4-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23ClO3
  1
1
EC50 = 262 nM
 Bioactivity Info 
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CP0063793
 Compound Info 
4-[1-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C26H32O2
  1
1
EC50 = 289 nM
 Bioactivity Info 
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CP0076318
 Compound Info 
4-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1
EC50 = 313 nM
 Bioactivity Info 
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CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O2
  1
1
EC50 = 486 nM
 Bioactivity Info 
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CP0063697
 Compound Info 
4-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C24H28O3
  1
1
EC50 = 810 nM
 Bioactivity Info 
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CP0049287
 Compound Info 
4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H24O3
  1
1
EC50 = 937 nM
 Bioactivity Info 
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CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  1
1
EC50 = 1211 nM
 Bioactivity Info 
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CP0184156
 Compound Info 
4-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23FO3
  1
1
EC50 = 1976 nM
 Bioactivity Info 
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CP0209249
 Compound Info 
4-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O4
  1
1
EC50 = 2200 nM
 Bioactivity Info 
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CP0041092
 Compound Info 
4-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H24O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
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CP0100726
 Compound Info 
4-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0123457
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C26H32O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  3
1 IC50 > 50000 nM
2 Kd = 306 nM
3 Kd = 1000 nM
CP0042976
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd = 6 nM
CP0042888
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-hexa-2,4-dienoic acid
   Show/Hide
C26H36O2
  1
1 Kd = 7 nM
CP0063990
 Compound Info 
(2E,4E)-6-[1-(3,5-Di-tert-butyl-phenyl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
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C24H34O2
  1
1 Kd = 8 nM
CP0042977
 Compound Info 
9-cis retinoic acid
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C20H28O2
  2
1 Kd = 12 nM
2 Kd = 15 nM
CP0105557
 Compound Info 
(2E,4E)-6-[1-(6-tert-Butyl-1,1-dimethyl-indan-4-yl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Kd = 15 nM
CP0122733
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
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C25H34O2
  1
1 Kd = 18 nM
CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
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C24H28O2
  2
1 Kd = 21 nM
2 Ki = 21 nM
CP0063958
 Compound Info 
4-[1-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H25BrO2
  1
1 Kd = 34 nM
CP0111163
 Compound Info 
4-[1-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H25ClO2
  1
1 Kd = 44 nM
CP0149955
 Compound Info 
4-[1-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C25H30O2
  1
1 Kd = 44 nM
CP0063793
 Compound Info 
4-[1-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C26H32O2
  1
1 Kd = 75 nM
CP0149843
 Compound Info 
4-[1-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H25FO2
  1
1 Kd = 108 nM
CP0144133
 Compound Info 
4-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23ClO3
  1
1 Kd = 110 nM
CP0186182
 Compound Info 
4-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H23BrO3
  1
1 Kd = 150 nM
CP0076318
 Compound Info 
4-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C25H30O3
  1
1 Kd = 155 nM
CP0105911
 Compound Info 
4-[1-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C24H28O3
  1
1 Kd = 191 nM
CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O3
  2
1 Kd = 191 nM
2 Kd = 232 nM
CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H26O2
  1
1 Kd = 199 nM
CP0063697
 Compound Info 
4-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C24H28O3
  1
1 Kd = 232 nM
CP0123457
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C26H32O2
  1
1 Kd = 236 nM
CP0100726
 Compound Info 
4-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C25H30O3
  1
1 Kd = 371 nM
CP0100503
 Compound Info 
4-[1-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H26O3
  1
1 Kd = 822 nM
CP0184156
 Compound Info 
4-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H23FO3
  1
1 Kd = 902 nM
CP0041092
 Compound Info 
4-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H24O4
  1
1 Kd > 1000 nM
CP0049287
 Compound Info 
4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H24O3
  1
1 Kd > 1000 nM
CP0209249
 Compound Info 
4-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C23H26O4
  1
1 Kd > 1000 nM
CP0135295
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Ki = 6 nM
CP0044733
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C26H36O2
  1
1 Ki = 10 nM
CP0059698
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C26H36O2
  1
1 Ki = 10 nM
CP0756593
 Compound Info 
3-Methyl-5-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-bicyclo[3.1.0]hex-1-yl]-penta-2,4-dienoic acid
   Show/Hide
C26H34O2
  1
1 Ki = 10 nM
CP0109273
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1 Ki = 11 nM
CP0277989
 Compound Info 
3-Methyl-5-[2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1 Ki = 25 nM
CP0059678
 Compound Info 
3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C25H32O2
  1
1 Ki = 36 nM
CP0102521
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1 Ki = 252 nM
CP0267152
 Compound Info 
(2E,4E)-3-Methyl-5-[(1S,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1 Ki = 556 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01474 Retinoic acid receptor RXR-beta Homo sapiens, Human
 Protein Info