General Information of the Protein
Protein ID
PT02527
Protein Name
Sodium- and chloride-dependent betaine transporter
Secondarily
Protein Name
BGT-1
Na(+)/Cl(-) betaine/GABA transporter
Solute carrier family 6 member 12
Gene Name
SLC6A12
Secondarily
Gene Name
BGT1
Sequence
MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTREGLIAGEKETHL
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Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation (By similarity).
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Uniprot ID
Primary ID:
P48065

Secondarily ID:
A0AV52
B2R992
D3DUN8
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Ensembl ID
ENSG00000111181
HGNC ID
HGNC:11045
Subcellular Location
Basolateral cell membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0413260
 Compound Info 
(1S,2S,5R)-5-aminobicyclo[3.1.0]hexane-2-carboxylic acid
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C7H11NO2
  1
1
IC50 = 590 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0390468
 Compound Info 
1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol
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C27H30N2O2
  1
1
IC50 = 5100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0860280
 Compound Info 
trans-(1S,2R)-2-amino-1-(carboxymethyl)cyclopropane hydrochloride
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C5H10ClNO2
  1
1
IC50 = 5480 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0386952
 Compound Info 
2-[(1S,2S)-2-aminocyclopropyl]acetic acid
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C5H9NO2
  1
1
IC50 = 5480 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0081174
 Compound Info 
(S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid
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C30H35NO6
  1
1
IC50 = 71700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000386 , Flp-In-CHO
 Cell Line Info 
Cell Line ID: CL000440 , LM
 Cell Line Info 
Cell Line ID: CL000027 , tsA201
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0000066
 Compound Info 
4-amino-n-[2,3-3H]butyric acid
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C4H9NO2
  1
1 IC50 = 36000 nM
Clinical Information about the Protein
Target 1 ( Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) )
Target Type Literature-reported Target