General Information of the Protein
Protein ID
PT02362
Protein Name
Serine/threonine-protein kinase TNNI3K
Secondarily
Protein Name
Cardiac ankyrin repeat kinase
Cardiac troponin I-interacting kinase
TNNI3-interacting kinase
Gene Name
TNNI3K
Secondarily
Gene Name
CARK
Sequence
MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase MLK family
>
TKL protein kinase HH498 subfamily
Function
May play a role in cardiac physiology.
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Uniprot ID
Primary ID:
Q59H18

Secondarily ID:
Q17RN0
Q49AR1
Q6MZS9
Q9Y2V6
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HGNC ID
HGNC:19661
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL001016 , HEKMSR2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0539464
 Compound Info 
3-[(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-4-(dimethylamino)-N-methylbenzenesulfonamide
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C15H17BrN6O2S
  1
1
IC50 = 0.7 nM
 Bioactivity Info 
   TI
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CP0539463
 Compound Info 
4-(dimethylamino)-N-methyl-3-[(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzenesulfonamide
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C16H20N6O2S
  1
1
IC50 = 1.6 nM
 Bioactivity Info 
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CP0549357
 Compound Info 
3-[(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-morpholin-4-ylbenzenesulfonamide
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C17H19BrN6O3S
  1
1
IC50 = 6.3 nM
 Bioactivity Info 
   TI
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CP0549099
 Compound Info 
N-methyl-3-[(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-4-morpholin-4-ylbenzenesulfonamide
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C18H22N6O3S
  1
1
IC50 = 7.9 nM
 Bioactivity Info 
   TI
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CP0229190
 Compound Info 
1-[3,5-dimethyl-4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C21H20F3N5O2
  1
1
IC50 = 7.9 nM
 Bioactivity Info 
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CP0229326
 Compound Info 
3-[[6-[(5-chloropyridin-2-yl)amino]pyrimidin-4-yl]amino]-4-ethylsulfonyl-N-methylbenzenesulfonamide
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C18H19ClN6O4S2
  1
1
IC50 = 8 nM
 Bioactivity Info 
   TI
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CP0415805
 Compound Info 
N-methyl-4-morpholin-4-yl-3-[[6-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzenesulfonamide
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C24H23F3N6O3S
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
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CP0445073
 Compound Info 
3-[(5,7-dimethoxyquinazolin-4-yl)amino]-4-(dimethylamino)-N-methylbenzenesulfonamide
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C19H23N5O4S
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
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CP0549653
 Compound Info 
3-[(5,7-dimethoxyquinazolin-4-yl)amino]-N-methyl-4-(2,2,2-trifluoroethoxy)benzenesulfonamide
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C19H19F3N4O5S
  1
1
IC50 = 13 nM
 Bioactivity Info 
   TI
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CP0539465
 Compound Info 
4-(dimethylamino)-N-methyl-3-[[6-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzenesulfonamide
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C22H21F3N6O2S
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
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CP0479450
 Compound Info 
1-[4-(6-aminopyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C18H14F3N5O2
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
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CP0364021
 Compound Info 
1-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C19H16F3N5O2
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0451859
 Compound Info 
4-(dimethylamino)-3-[[7-(3-methoxypropoxy)quinazolin-4-yl]amino]-N-methylbenzenesulfonamide
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C21H27N5O4S
  1
1
IC50 = 25 nM
 Bioactivity Info 
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CP0509693
 Compound Info 
4-(dimethylamino)-N-methyl-3-[[7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]benzenesulfonamide
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C24H32N6O4S
  1
1
IC50 = 25 nM
 Bioactivity Info 
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CP0397379
 Compound Info 
3-[(6-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-4-(dimethylamino)-N-methylbenzenesulfonamide
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C15H17BrN6O2S
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0229319
 Compound Info 
1-[4-[6-(2-hydroxyethylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C20H18F3N5O3
  1
1
IC50 = 40 nM
 Bioactivity Info 
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CP0199737
 Compound Info 
4-(dimethylamino)-N-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide
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C15H18N6O2S
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0464125
 Compound Info 
4-(dimethylamino)-N-methyl-3-[(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)amino]benzenesulfonamide
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C16H20N6O2S
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
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CP0464126
 Compound Info 
3-[(7-ethoxy-6-methoxyquinazolin-4-yl)amino]-N-methyl-4-(2,2,2-trifluoroethoxy)benzenesulfonamide
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C20H21F3N4O5S
  1
1
IC50 = 50 nM
 Bioactivity Info 
   TI
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CP0363925
 Compound Info 
1-[4-[6-[(2-hydroxy-2-methylpropyl)amino]pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C22H22F3N5O3
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0549654
 Compound Info 
N-methyl-4-(2,2,2-trifluoroethoxy)-3-[(5,6,7-trimethoxyquinazolin-4-yl)amino]benzenesulfonamide
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C20H21F3N4O6S
  1
1
IC50 = 63 nM
 Bioactivity Info 
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CP0556553
 Compound Info 
N-methyl-3-[[7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]-4-(2,2,2-trifluoroethoxy)benzenesulfonamide
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C24H28F3N5O5S
  1
1
IC50 = 79 nM
 Bioactivity Info 
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CP0431391
 Compound Info 
N-methyl-4-morpholin-4-yl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide
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C17H20N6O3S
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0016176
 Compound Info 
3-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-(dimethylamino)-N-methylbenzenesulfonamide
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C19H23N5O4S
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0266071
 Compound Info 
1-[3-chloro-5-ethyl-4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C21H19ClF3N5O2
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0364443
 Compound Info 
1-[3,5-dichloro-4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C19H14Cl2F3N5O2
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0573902
 Compound Info 
3-[(6,7-dimethoxyquinazolin-4-yl)amino]-N-methyl-4-(2,2,2-trifluoroethoxy)benzenesulfonamide
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C19H19F3N4O5S
  1
1
IC50 = 160 nM
 Bioactivity Info 
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CP0018477
 Compound Info 
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
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C21H16ClF3N4O3
  1
1
IC50 = 250 nM
 Bioactivity Info 
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CP0451860
 Compound Info 
3-[[7-(3-methoxypropoxy)quinazolin-4-yl]amino]-N-methyl-4-(2,2,2-trifluoroethoxy)benzenesulfonamide
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C21H23F3N4O5S
  1
1
IC50 = 320 nM
 Bioactivity Info 
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CP0539466
 Compound Info 
3-[(6-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-morpholin-4-ylbenzenesulfonamide
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C17H19BrN6O3S
  1
1
IC50 = 398 nM
 Bioactivity Info 
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CP0451857
 Compound Info 
4-(dimethylamino)-N-methyl-3-(5H-pyrrolo[3,2-d]pyrimidin-4-ylamino)benzenesulfonamide
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C15H18N6O2S
  1
1
IC50 = 500 nM
 Bioactivity Info 
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Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0229326
 Compound Info 
3-[[6-[(5-chloropyridin-2-yl)amino]pyrimidin-4-yl]amino]-4-ethylsulfonyl-N-methylbenzenesulfonamide
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C18H19ClN6O4S2
  1
1 IC50 <= 10 nM
CP0266071
 Compound Info 
1-[3-chloro-5-ethyl-4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C21H19ClF3N5O2
  1
1 IC50 <= 10 nM
CP0364443
 Compound Info 
1-[3,5-dichloro-4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C19H14Cl2F3N5O2
  2
1 IC50 = 10 nM
2 Ki = 0.54 nM
CP0016176
 Compound Info 
3-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-(dimethylamino)-N-methylbenzenesulfonamide
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C19H23N5O4S
  1
1 IC50 = 25 nM
CP0229190
 Compound Info 
1-[3,5-dimethyl-4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C21H20F3N5O2
  1
1 IC50 = 25 nM
CP0479450
 Compound Info 
1-[4-(6-aminopyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C18H14F3N5O2
  1
1 IC50 = 25 nM
CP0229319
 Compound Info 
1-[4-[6-(2-hydroxyethylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C20H18F3N5O3
  1
1 IC50 = 32 nM
CP0363925
 Compound Info 
1-[4-[6-[(2-hydroxy-2-methylpropyl)amino]pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C22H22F3N5O3
  1
1 IC50 = 40 nM
CP0364021
 Compound Info 
1-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea
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C19H16F3N5O2
  1
1 IC50 = 40 nM
CP0199737
 Compound Info 
4-(dimethylamino)-N-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide
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C15H18N6O2S
  1
1 IC50 = 50 nM
CP0018477
 Compound Info 
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
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C21H16ClF3N4O3
  2
1 IC50 = 100 nM
2 Kd = 280 nM