General Information of the Protein
Protein ID
PT01943
Protein Name
Phospholipase D1
Secondarily
Protein Name
Choline phosphatase 1
Phosphatidylcholine-hydrolyzing phospholipase D1
Gene Name
PLD1
Sequence
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSAIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313, PubMed:25936805). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
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Uniprot ID
Q13393
Ensembl ID
ENSG00000075651
HGNC ID
HGNC:9067
Subcellular Location
Cytoplasm
Perinuclear region
Endoplasmic reticulum membrane
Golgi apparatus membrane
Late endosome membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000817 , 293/GFP
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0922188
 Compound Info 
Rac-N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propyl)-1H-indole-2-carboxamide
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C25H29N5O2
  1
1
IC50 = 6 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0556358
 Compound Info 
3,4-difluoro-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propyl]benzamide
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C23H26F2N4O2
  1
1
IC50 = 17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0957723
 Compound Info 
Rac-5-fluoro-N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propyl)-1H-indole-2-carboxamide
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C25H28FN5O2
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0508298
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propyl]naphthalene-2-carboxamide
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C27H30N4O2
  1
1
IC50 = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0920984
 Compound Info 
3,4-difluoro-N-(2-(3-fluoro-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide
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C21H21F3N4O2
  1
1
IC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0922189
 Compound Info 
(trans)-N-(2-(5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl)-2-phenylcyclopropanecarboxamide
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C26H30N4O2
  1
1
IC50 = 115 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0481699
 Compound Info 
4-bromo-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propyl]benzamide
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C23H27BrN4O2
  1
1
IC50 = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0904840
 Compound Info 
N-(2-(5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl)-1H-indole-2-carboxamide
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C25H27N5O2
  1
1
IC50 = 220 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0508297
 Compound Info 
4-fluoro-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propyl]benzamide
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C23H27FN4O2
  1
1
IC50 = 290 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0957724
 Compound Info 
5-fluoro-N-(2-(5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl)-1H-indole-2-carboxamide
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C25H26FN5O2
  1
1
IC50 = 1235 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0858428
 Compound Info 
N-(2-(5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl)-2-naphthamide
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C27H28N4O2
  1
1
IC50 = 1790 nM
 Bioactivity Info 
   TI
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CP0897028
 Compound Info 
4-bromo-N-(2-(5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl)benzamide
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C23H25BrN4O2
  1
1
IC50 = 2590 nM
 Bioactivity Info 
   TI
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CP0963742
 Compound Info 
(trans)-N-(2-(2-methyl-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-phenylcyclopropanecarboxamide
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C25H30N4O2
  1
1
IC50 = 2770 nM
 Bioactivity Info 
   TI
   LI
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CP0946025
 Compound Info 
3,4-difluoro-N-(2-(5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl)benzamide
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C23H24F2N4O2
  1
1
IC50 = 3250 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0921003
 Compound Info 
4-fluoro-N-(2-(5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl)benzamide
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C23H25FN4O2
  1
1
IC50 = 3565 nM
 Bioactivity Info 
   TI
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CP0922190
 Compound Info 
4-fluoro-N-(2-(2-methyl-4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide
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C22H25FN4O2
  1
1
IC50 = 7315 nM
 Bioactivity Info 
   TI
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Cell Line ID: CL000385 , Calu-1
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0143509
 Compound Info 
(1R,2R)-N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-2-phenyl-cyclopropanecarboxamide;2,2,2-trifluoroacetic acid
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C25H29BrN4O2
  1
1 IC50 = 3.7 nM
CP0230203
 Compound Info 
ML299 (5)
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C23H26BrFN4O2
  1
1 IC50 = 6 nM
CP0038642
 Compound Info 
5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide, 14
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C23H24FN5O2
  1
1 IC50 = 9.5 nM
CP0070013
 Compound Info 
US9453017, 2
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C25H29BrN4O2
  1
1 IC50 = 15 nM
CP0136322
 Compound Info 
N-[2-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide
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C21H22ClFN4O2
  2
1 IC50 = 21 nM
2 IC50 = 220 nM
CP0038644
 Compound Info 
3,4-Dichloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 48
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C21H22Cl2N4O2
  1
1 IC50 = 46 nM
CP0228146
 Compound Info 
(S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide, 69
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C26H27ClN4O2
  1
1 IC50 = 46 nM
CP0086302
 Compound Info 
4-bromo-N-[(2S)-1-[1-(3-methylphenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
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C24H29BrN4O2
  1
1 IC50 = 48 nM
CP0136333
 Compound Info 
4-Chloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 50
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C21H23ClN4O2
  1
1 IC50 = 55 nM
CP0038636
 Compound Info 
3,4,5-Trimethoxy-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 55
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C24H30N4O5
  1
1 IC50 = 59 nM
CP0297516
 Compound Info 
4,5-Dibromo-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)furan-2-carboxamide, 64
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C19H20Br2N4O3
  1
1 IC50 = 79 nM
CP0238288
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide
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C25H26N4O2
  2
1 IC50 = 80 nM
2 IC50 = 81 nM
CP0144408
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1-benzothiophene-2-carboxamide
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C23H24N4O2S
  1
1 IC50 = 100 nM
CP0228121
 Compound Info 
9-Oxo-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-9H-fluorene-4-carboxamide, 57
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C28H26N4O3
  1
1 IC50 = 260 nM
CP0125380
 Compound Info 
CID25105707
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C27H27N5O2
  1
1 IC50 = 300 nM
CP0240265
 Compound Info 
CID25105709
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C19H23N5O2
  1
1 IC50 = 316 nM
CP0228470
 Compound Info 
CID21428857
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C19H22N4O3
  1
1 IC50 = 360 nM
CP0268921
 Compound Info 
3,5-Dichloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 49
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C21H22Cl2N4O2
  1
1 IC50 = 400 nM
CP0136326
 Compound Info 
3,4-Difluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 47
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C21H22F2N4O2
  1
1 IC50 = 480 nM
CP0038649
 Compound Info 
CID25105702
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C23H26N4O2
  1
1 IC50 = 540 nM
CP0234014
 Compound Info 
(1R,2R)-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-phenylcyclopropanecarboxamide, 58
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C24H28N4O2
  1
1 IC50 = 660 nM
CP0136331
 Compound Info 
4-Methyl-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 52
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C22H26N4O2
  1
1 IC50 = 780 nM
CP0238366
 Compound Info 
2-Chloro-N-(2-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 68
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C21H22Cl2N4O2
  1
1 IC50 = 1200 nM
CP0240263
 Compound Info 
4-Fluoro-N-(4-fluorobenzoyl)-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 66
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C28H26F2N4O3
  1
1 IC50 = 1400 nM
CP0267179
 Compound Info 
N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide
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C26H27FN4O2
  1
1 IC50 = 1500 nM
CP0216109
 Compound Info 
CID25105697
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C30H50N4O2
  1
1 IC50 = 3200 nM
CP0041761
 Compound Info 
2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol
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C28H27NO4S
  2
1 IC50 = 4000 nM
2 IC50 = 4300 nM
CP0238293
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide
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C26H28N4O2
  1
1 IC50 = 5100 nM
CP0216108
 Compound Info 
CID25105708
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C22H26N4O2S
  1
1 IC50 = 7400 nM
CP0252534
 Compound Info 
US9453017, 1
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C26H27FN4O2
  1
1 IC50 = 7400 nM
CP0293764
 Compound Info 
4-Methoxy-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 51
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C22H26N4O3
  1
1 IC50 = 15000 nM
CP0145932
 Compound Info 
3,4-bis(fluoranyl)-N-[2-[1-(3-fluorophenyl)-4-oxidanylidene-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
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C22H23F3N4O2
  1
1 IC50 = 20000 nM
CP0140910
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-2-carboxamide
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C25H27N5O2
  1
1 IC50 > 20000 nM
CP0234018
 Compound Info 
4-Chloro-N-(4-chlorobenzoyl)-N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamide, 82
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C29H28Cl2N4O3
  1
1 IC50 > 20000 nM
Clinical Information about the Protein
Target 1 ( Phospholipase D1 (PLD1) )
Target Type Patented-recorded Target