General Information of the Compound
Compound ID
CP0957724
Compound Name
5-fluoro-N-(2-(5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl)-1H-indole-2-carboxamide
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Structure
Formula
C25H26FN5O2
Molecular Weight
447.514
Canonical SMILES
O=C(NCCN1CC2CC(n3c(=O)[nH]c4ccccc43)CC2C1)c1cc2cc(F)ccc2[nH]1
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InChI
InChI=1S/C25H26FN5O2/c26-18-5-6-20-15(9-18)12-22(28-20)24(32)27-7-8-30-13-16-10-19(11-17(16)14-30)31-23-4-2-1-3-21(23)29-25(31)33/h1-6,9,12,16-17,19,28H,7-8,10-11,13-14H2,(H,27,32)(H,29,33)
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InChIKey
SHTZQICSLLBOBJ-UHFFFAOYSA-N
Physicochemical Property
logP
3.2629
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
85.92
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118722113
ChEMBL ID
CHEMBL3357319
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01943, Phospholipase D1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000385 Calu-1 Homo sapiens (Human)  1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CL000817 293/GFP Homo sapiens (Human)  1
1
IC50 = 1235 nM
   TI
   LI
   LO
   TS