General Information of the Protein
Protein ID
PT01816
Protein Name
Thymidine phosphorylase
Secondarily
Protein Name
Gliostatin
Platelet-derived endothelial cell growth factor
TdRPase
Gene Name
TYMP
Secondarily
Gene Name
ECGF1
Sequence
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
Function
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
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Uniprot ID
Primary ID:
P19971

Secondarily ID:
A8MW15
H9KVA0
Q13390
Q8WVB7
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Ensembl ID
ENSG00000025708
HGNC ID
HGNC:3148
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000191 , V79
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0740877
 Compound Info 
5-bromo-6-({2-[(5-bromo-2,6-dioxopyrimidin-4(1H,3H)-yl)amino]ethyl}amino)pyrimidine-2,4(1H,3H)-dione dihydrochloride
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C10H12Br2Cl2N6O4
  1
1
IC50 = 3400 nM
 Bioactivity Info 
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CP0702159
 Compound Info 
5-bromo-6-hydrazinouracil hydrochloride
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C4H6BrClN4O2
  1
1
IC50 = 3800 nM
 Bioactivity Info 
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CP0795559
 Compound Info 
5-bromo-6-[4-(5-bromo-2,6-dioxopyrimidin-4(1H,3H)-yl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione dihydrochloride
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C12H14Br2Cl2N6O4
  1
1
IC50 = 4000 nM
 Bioactivity Info 
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CP0806767
 Compound Info 
5-bromo-6-(4-(2-hydroxyethyl)piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C11H17BrClN3O3
  1
1
IC50 = 5000 nM
 Bioactivity Info 
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CP0714625
 Compound Info 
5-bromo-6-(pyrrolidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C8H11BrClN3O2
  1
1
IC50 = 5100 nM
 Bioactivity Info 
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CP0807081
 Compound Info 
5-bromo-6-(3-(hydroxymethyl)piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C10H15BrClN3O3
  1
1
IC50 = 5200 nM
 Bioactivity Info 
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CP0716989
 Compound Info 
6-(azetidin-1-yl)-5-bromopyrimidine-2,4(1H,3H)-dione hydrochloride
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C7H9BrClN3O2
  1
1
IC50 = 6800 nM
 Bioactivity Info 
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CP0825996
 Compound Info 
5-bromo-6-(2-(hydroxymethyl)piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C10H15BrClN3O3
  1
1
IC50 = 7000 nM
 Bioactivity Info 
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CP0926784
 Compound Info 
5-chloro-6-(cyclopropylamino)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C7H9Cl2N3O2
  1
1
IC50 = 7000 nM
 Bioactivity Info 
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CP0731283
 Compound Info 
5-bromo-6-(cyclopropylamino)uracil hydrochloride
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C7H9BrClN3O2
  1
1
IC50 = 7200 nM
 Bioactivity Info 
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CP0808434
 Compound Info 
5-bromo-6-morpholinopyrimidine-2,4(1H,3H)-dione hydrochloride
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C8H11BrClN3O3
  1
1
IC50 = 7200 nM
 Bioactivity Info 
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CP0959117
 Compound Info 
5-chloro-6-[4-(5-chloro-2,6-dioxopyrimidin-4(1H,3H)-yl)piperazin-1-yl]pyrimidine-2,4(1H,3H)-dione dihydrochloride
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C12H14Cl4N6O4
  1
1
IC50 = 7200 nM
 Bioactivity Info 
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CP0697744
 Compound Info 
5-bromo-6-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C10H15BrClN3O3
  1
1
IC50 = 7500 nM
 Bioactivity Info 
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CP0806766
 Compound Info 
5-chloro-6-(3-(2-hydroxyethyl)piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C11H17Cl2N3O3
  1
1
IC50 = 7500 nM
 Bioactivity Info 
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CP0731710
 Compound Info 
6-(azetidin-1-yl)-5-chloropyrimidine-2,4(1H,3H)-dione hydrochloride
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C7H9Cl2N3O2
  1
1
IC50 = 8000 nM
 Bioactivity Info 
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CP0795560
 Compound Info 
5-chloro-6-(2-(hydroxymethyl)piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C10H15Cl2N3O3
  1
1
IC50 = 8000 nM
 Bioactivity Info 
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CP0720362
 Compound Info 
5-bromo-6-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C9H13BrClN3O2
  1
1
IC50 = 8200 nM
 Bioactivity Info 
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CP0795549
 Compound Info 
5-chloro-6-morpholinopyrimidine-2,4(1H,3H)-dione hydrochloride
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C8H11Cl2N3O3
  1
1
IC50 = 8300 nM
 Bioactivity Info 
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CP0731709
 Compound Info 
5-chloro-6-(3-(hydroxymethyl)piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C10H15Cl2N3O3
  1
1
IC50 = 9000 nM
 Bioactivity Info 
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CP0707885
 Compound Info 
5-chloro-6-(pyrrolidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C8H11Cl2N3O2
  1
1
IC50 = 9500 nM
 Bioactivity Info 
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CP0723392
 Compound Info 
5-chloro-6-hydrazinouracil hydrochloride
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C4H6Cl2N4O2
  1
1
IC50 = 10200 nM
 Bioactivity Info 
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CP0697742
 Compound Info 
6-amino-5-chlorouracil hydrochloride
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C4H5Cl2N3O2
  1
1
IC50 = 11600 nM
 Bioactivity Info 
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CP0795561
 Compound Info 
5-chloro-6-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione hydrochloride
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C9H13Cl2N3O2
  1
1
IC50 = 15700 nM
 Bioactivity Info 
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CP0092617
 Compound Info 
5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
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C9H11ClN4O2
  1
1
Ki = 1.3 nM
 Bioactivity Info 
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CP0524537
 Compound Info 
5-Substituted-6-chlorouracil, 7a
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C9H9ClN2O2
  1
1
Ki = 200 nM
 Bioactivity Info 
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CP0484412
 Compound Info 
5-Substituted-6-chlorouracil, 10e
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C8H5ClN2O2S
  1
1
Ki = 280 nM
 Bioactivity Info 
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CP0500932
 Compound Info 
5-Substituted-6-chlorouracil, 10a
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C10H7ClN2O2
  1
1
Ki = 400 nM
 Bioactivity Info 
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CP0845137
 Compound Info 
6-chloro-5-[(1E)-pent-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione
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C9H11ClN2O2
  1
1
Ki = 410 nM
 Bioactivity Info 
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CP0467174
 Compound Info 
5-Substituted-6-chlorouracil, 7b
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C10H11ClN2O2
  1
1
Ki = 420 nM
 Bioactivity Info 
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CP0879673
 Compound Info 
6-chloro-5-[(1E)-1-ethylprop-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione
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C9H11ClN2O2
  1
1
Ki = 490 nM
 Bioactivity Info 
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CP0489293
 Compound Info 
6-Fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione, 21
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C10H7FN2O2
  1
1
Ki = 500 nM
 Bioactivity Info 
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CP0910674
 Compound Info 
5-[(1E)-but-1-en-1-yl]-6-chloropyrimidine-2,4(1H,3H)-dione
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C8H9ClN2O2
  1
1
Ki = 630 nM
 Bioactivity Info 
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CP0500931
 Compound Info 
5-Substituted-6-chlorouracil, 10d
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C10H6ClFN2O2
  1
1
Ki = 710 nM
 Bioactivity Info 
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CP0373172
 Compound Info 
5-Substituted-6-chlorouracil, 5c
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C8H11ClN2O2
  1
1
Ki = 1030 nM
 Bioactivity Info 
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CP0489315
 Compound Info 
5-Substituted-6-chlorouracil, 5f
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C11H17ClN2O2
  1
1
Ki = 1060 nM
 Bioactivity Info 
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CP0906066
 Compound Info 
6-chloro-5-[(1E)-prop-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione
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C7H7ClN2O2
  1
1
Ki = 1170 nM
 Bioactivity Info 
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CP0490924
 Compound Info 
6-Bromo-5-phenylpyrimidine-2,4(1H,3H)-dione, 23
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C10H7BrN2O2
  1
1
Ki = 1210 nM
 Bioactivity Info 
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CP0528114
 Compound Info 
5-Substituted-6-chlorouracil, 10b
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C12H11ClN2O2
  1
1
Ki = 1740 nM
 Bioactivity Info 
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CP0477931
 Compound Info 
5-Substituted-6-chlorouracil, 5e
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C10H15ClN2O2
  1
1
Ki = 1830 nM
 Bioactivity Info 
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CP0906067
 Compound Info 
6-chloro-5-pyridin-3-ylpyrimidine-2,4(1H,3H)-dione hydrochloride
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C9H7Cl2N3O2
  1
1
Ki = 3010 nM
 Bioactivity Info 
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CP0405260
 Compound Info 
5-Substituted-6-chlorouracil, 7c
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C7H7ClN2O2
  1
1
Ki = 3340 nM
 Bioactivity Info 
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CP0489295
 Compound Info 
5-Substituted-6-chlorouracil, 5d
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C9H13ClN2O2
  1
1
Ki = 3670 nM
 Bioactivity Info 
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CP0438978
 Compound Info 
5-Substituted-6-chlorouracil, 10c
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C14H9ClN2O2
  1
1
Ki = 4590 nM
 Bioactivity Info 
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CP0489314
 Compound Info 
5-Substituted-6-chlorouracil, 5g
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C11H9ClN2O2
  1
1
Ki = 4650 nM
 Bioactivity Info 
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CP0467173
 Compound Info 
5-Substituted-6-chlorouracil, 5b
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C7H9ClN2O2
  1
1
Ki = 5810 nM
 Bioactivity Info 
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CP0373170
 Compound Info 
5-Phenyl-6-pyrrolidin-1-ylpyrimidine-2,4(1H,3H)-dione, 24
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C14H15N3O2
  1
1
Ki > 20000 nM
 Bioactivity Info 
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CP0477930
 Compound Info 
6-Methyl-5-phenylpyrimidine-2,4(1H,3H)-dione, 16
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C11H10N2O2
  1
1
Ki > 20000 nM
 Bioactivity Info 
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CP0511118
 Compound Info 
5-Substituted-6-chlorouracil, 5a
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C6H7ClN2O2
  1
1
Ki > 20000 nM
 Bioactivity Info 
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CP0528111
 Compound Info 
6-[(2-Aminoethyl)amino]-5-phenylpyrimidine-2,4(1H,3H)-dione, 25
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C12H14N4O2
  1
1
Ki > 20000 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0092617
 Compound Info 
5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
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C9H11ClN4O2
  5
1 IC50 = 20 nM
2 IC50 = 35 nM
3 Ki = 5 nM
4 Ki = 17 nM
5 Ki = 20 nM
Clinical Information about the Protein
Target 1 ( Thymidine phosphorylase (TYMP) )
Target Type Successful Target
Disease 1 Target-related Disease  1
1 Depression [ICD-11: 6A70-6A7Z]
Approved Drug(s) 1 Approved Drug  1
1 Uridine
 Drug Info 
Approved
Depression