Protein Information

General Information of the Protein

Protein ID	PT01734
Protein Name	D(2) dopamine receptor
Secondarily Protein Name	Dopamine D2 receptor
Gene Name	DRD2
Sequence	MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC Show/Hide
Organism	Bos taurus, Bovine
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Dopamine receptor
Function	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). Show/Hide
Uniprot ID	P20288
Ensembl ID	ENSG00000149295
Subcellular Location	Cell membrane Golgi apparatus membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0008601 Compound Info	4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Show/Hide	C21H23ClFNO2	2
1	Ki = 0.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 0.7 nM Bioactivity Info	TI LI LO TS
CP0409085 Compound Info	((1S,2R)-5-Methoxy-1-methyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine Show/Hide	C18H29NO	2
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
2	Ki = 18 nM Bioactivity Info	TI LI LO TS
CP0448607 Compound Info	(-)-Trifluoro-methanesulfonic acid 3-(1-propyl-piperidin-3-yl)-phenyl ester Show/Hide	C15H20F3NO3S	2
1	Ki = 40 nM Bioactivity Info	TI LI LO TS
2	Ki = 180 nM Bioactivity Info	TI LI LO TS
CP0338014 Compound Info	AJ 76 Show/Hide	C15H23NO	2
1	Ki = 145 nM Bioactivity Info	TI LI LO TS
2	Ki = 158 nM Bioactivity Info	TI LI LO TS
CP0470701 Compound Info	(+)-Trifluoro-methanesulfonic acid 3-(1-propyl-piperidin-3-yl)-phenyl ester Show/Hide	C15H20F3NO3S	1
1	Ki > 2000 nM Bioactivity Info	TI LI LO TS

Cell Line Info

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01005	D(2) dopamine receptor	Homo sapiens, Human	Protein Info
PT02458	5-hydroxytryptamine receptor 1F	Homo sapiens, Human	Protein Info