General Information of the Protein
Protein ID
PT01730
Protein Name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Secondarily
Protein Name
CGIPDE1
Cyclic GMP-inhibited phosphodiesterase B
Gene Name
PDE3B
Sequence
MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGDAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQADEIQVIEEADEEE
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Phosphodiesterase
>
Phosphodiesterase 3
>
Phosphodiesterase 3B
Function
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity).
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Uniprot ID
Primary ID:
Q13370

Secondarily ID:
B7ZM37
O00639
Q14408
Q6SEI4
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HGNC ID
HGNC:8779
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0542604
 Compound Info 
[3-[5-(difluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl]piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C21H22F2N4OS
  1
1
IC50 = 78 nM
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CP0484243
 Compound Info 
[3-(5-methoxy-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C20H23N5O2S
  1
1
IC50 = 115 nM
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CP0401835
 Compound Info 
4-(3,4-dimethoxyphenyl)-N-pyridin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide
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C19H15F3N4O3
  1
1
IC50 = 169 nM
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CP0366154
 Compound Info 
N-(3,5-dichloropyridin-4-yl)-4-(3,4-dimethoxyphenyl)-2-(trifluoromethyl)pyrimidine-5-carboxamide
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C19H13Cl2F3N4O3
  1
1
IC50 = 321 nM
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CP0491961
 Compound Info 
[3-(7-methylimidazo[1,2-a]pyrimidin-5-yl)piperidin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C21H24N4OS
  1
1
IC50 = 347 nM
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CP0527831
 Compound Info 
cyclohexyl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C17H23N5O
  1
1
IC50 = 617 nM
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CP0532947
 Compound Info 
7-[1-(4,5,6,7-tetrahydro-1-benzothiophene-2-carbonyl)piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine-5-carbonitrile
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C20H20N6OS
  1
1
IC50 = 676 nM
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CP0249165
 Compound Info 
N-(3,4-dimethoxyphenyl)-2-methylsulfanyl-4-morpholin-4-ylpyrimidine-5-carboxamide
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C18H22N4O4S
  1
1
IC50 = 800 nM
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CP0401837
 Compound Info 
N-(3,4-dimethoxyphenyl)-4-morpholin-4-yl-2-(trifluoromethyl)pyrimidine-5-carboxamide
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C18H19F3N4O4
  1
1
IC50 = 950 nM
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CP0550584
 Compound Info 
1-benzofuran-5-yl-[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C19H17N5O2
  1
1
IC50 = 1622 nM
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CP0498448
 Compound Info 
(2-methoxyphenyl)-[(3S)-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone
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C18H19N5O2
  1
1
IC50 = 3388 nM
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CP0553977
 Compound Info 
[4-methyl-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)methanone
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C19H22N6OS
  1
1
IC50 = 5495 nM
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CP0414199
 Compound Info 
4-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine
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C21H20ClN5O
  1
1
IC50 > 10000 nM
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CP0000847
 Compound Info 
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione
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C22H19N3O4
  1
1
IC50 > 10000 nM
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CP0109248
 Compound Info 
(2S,8R)-2-(5-bromothiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C19H16BrN3O2S
  1
1
IC50 > 20000 nM
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CP0109250
 Compound Info 
(2S,8R)-6-methyl-2-(5-methylthiophen-2-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C20H19N3O2S
  1
1
IC50 > 20000 nM
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CP0144390
 Compound Info 
(2S,8R)-2-(5-ethylfuran-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C21H21N3O3
  1
1
IC50 > 20000 nM
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CP0157968
 Compound Info 
(10S,15S)-13-ethyl-10-(5-methylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C20H19N3O3
  1
1
IC50 > 20000 nM
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CP0157969
 Compound Info 
(10S,15S)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O2S
  1
1
IC50 > 20000 nM
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CP0164472
 Compound Info 
(10S,15R)-13-ethyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O2S
  1
1
IC50 > 20000 nM
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CP0168902
 Compound Info 
(10S,15R)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O3
  1
1
IC50 > 20000 nM
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CP0257911
 Compound Info 
(10S,15S)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O3
  1
1
IC50 > 20000 nM
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CP0268684
 Compound Info 
(2S,8R)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C21H21N3O2S
  1
1
IC50 > 20000 nM
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CP0392073
 Compound Info 
(10S,15S)-13-butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C23H25N3O2S
  1
1
IC50 > 20000 nM
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CP0392075
 Compound Info 
(10R,15R)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C21H21N3O3
  1
1
IC50 > 20000 nM
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CP0392491
 Compound Info 
(2R,8S)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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C21H21N3O2S
  1
1
IC50 > 20000 nM
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CP0432292
 Compound Info 
(10S,15R)-13-butyl-10-(5-ethylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C23H25N3O2S
  1
1
IC50 > 20000 nM
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CP0440103
 Compound Info 
(10S,15S)-13-ethyl-10-(3-methylthiophen-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
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C20H19N3O2S
  1
1
IC50 > 20000 nM
 Bioactivity Info 
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CP0205820
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(naphthalen-1-yloxy)-pyrrolidin-1-yl]-quinazoline
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C24H23N3O3
  1
1
Ki = 56 nM
 Bioactivity Info 
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CP0091866
 Compound Info 
(R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C22H25N3O4
  1
1
Ki = 88 nM
 Bioactivity Info 
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CP0091864
 Compound Info 
(R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidin-3-yloxy]-benzonitrile
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C21H20N4O3
  1
1
Ki < 100 nM
 Bioactivity Info 
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CP0103705
 Compound Info 
(R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)-quinazoline
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C21H23N3O3
  1
1
Ki < 100 nM
 Bioactivity Info 
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CP0160131
 Compound Info 
(R)-4-[3-(2-Chloro-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C20H20ClN3O3
  1
1
Ki < 100 nM
 Bioactivity Info 
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CP0038129
 Compound Info 
(R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C23H22N4O3
  1
1
Ki = 196 nM
 Bioactivity Info 
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CP0109409
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolidin-1-yl]-quinazoline
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C23H22N4O3
  1
1
Ki = 201 nM
 Bioactivity Info 
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CP0038130
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C19H20N4O3
  1
1
Ki = 207 nM
 Bioactivity Info 
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CP0103703
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(2-methyl-quinolin-6-yloxy)-pyrrolidin-1-yl]-quinazoline
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C24H24N4O3
  1
1
Ki = 223 nM
 Bioactivity Info 
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CP0109410
 Compound Info 
(R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C23H25N3O3
  1
1
Ki = 237 nM
 Bioactivity Info 
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CP0117972
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(quinolin-7-yloxy)-pyrrolidin-1-yl]-quinazoline
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C23H22N4O3
  1
1
Ki = 240 nM
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CP0103707
 Compound Info 
(R)-4-[3-(3,4-Dimethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C22H25N3O5
  1
1
Ki = 260 nM
 Bioactivity Info 
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CP0117968
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C22H21N5O3
  1
1
Ki = 273 nM
 Bioactivity Info 
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CP0091873
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(6-methoxy-naphthalen-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C25H25N3O4
  1
1
Ki = 280 nM
 Bioactivity Info 
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CP0202707
 Compound Info 
(R)-4-[3-(Biphenyl-3-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C26H25N3O3
  1
1
Ki = 280 nM
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CP0038124
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(7-methoxy-naphthalen-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C25H25N3O4
  1
1
Ki = 305 nM
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CP0160129
 Compound Info 
(R)-4-[3-(4-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C22H25N3O4
  1
1
Ki = 328 nM
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CP0156978
 Compound Info 
(R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C18H18ClN5O3
  1
1
Ki = 332 nM
 Bioactivity Info 
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CP0083432
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline
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C20H21NO4
  1
1
Ki = 417 nM
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CP0117969
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(naphthalen-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C24H23N3O3
  1
1
Ki = 463 nM
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CP0103708
 Compound Info 
(R)-4-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidin-3-yloxy]-benzonitrile
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C21H20N4O3
  1
1
Ki = 471 nM
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CP0419676
 Compound Info 
(R)-4-[3-(3-Isopropyl-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C23H27N3O3
  1
1
Ki = 474 nM
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CP0156977
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidin-1-yl]-quinazoline
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C19H20N4O3
  1
1
Ki = 685 nM
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CP0038128
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidin-1-yl]-quinazoline
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C19H20N4O3
  1
1
Ki = 748 nM
 Bioactivity Info 
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CP0428130
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(4-trifluoromethoxy-phenoxy)-pyrrolidin-1-yl]-quinazoline
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C21H20F3N3O4
  1
1
Ki = 1820 nM
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CP0091870
 Compound Info 
(R)-4-[3-(4-tert-Butyl-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C24H29N3O3
  1
1
Ki = 1890 nM
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CP0091868
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrrolidin-1-yl]-quinazoline
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C21H23N3O4
  1
1
Ki > 100 nM
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CP0103710
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)-pyrrolidin-1-yl]-quinazoline
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C21H20F3N3O3
  1
1
Ki > 100 nM
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CP0502730
 Compound Info 
(S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrrolidin-1-yl]-quinazoline
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C21H23N3O4
  1
1
Ki > 100 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0083432
 Compound Info 
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline
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C20H21NO4
  1
1 IC50 = 1030 nM
CP0000847
 Compound Info 
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione
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C22H19N3O4
  1
1 IC50 > 50000 nM
CP0205820
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(naphthalen-1-yloxy)-pyrrolidin-1-yl]-quinazoline
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C24H23N3O3
  1
1 Ki = 56 nM
CP0091866
 Compound Info 
(R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C22H25N3O4
  1
1 Ki = 88 nM
CP0091864
 Compound Info 
(R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidin-3-yloxy]-benzonitrile
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C21H20N4O3
  1
1 Ki < 100 nM
CP0103705
 Compound Info 
(R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)-quinazoline
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C21H23N3O3
  1
1 Ki < 100 nM
CP0160131
 Compound Info 
(R)-4-[3-(2-Chloro-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C20H20ClN3O3
  1
1 Ki < 100 nM
CP0038129
 Compound Info 
(R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C23H22N4O3
  1
1 Ki = 196 nM
CP0109409
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolidin-1-yl]-quinazoline
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C23H22N4O3
  1
1 Ki = 201 nM
CP0038130
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C19H20N4O3
  1
1 Ki = 207 nM
CP0103703
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(2-methyl-quinolin-6-yloxy)-pyrrolidin-1-yl]-quinazoline
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C24H24N4O3
  1
1 Ki = 223 nM
CP0109410
 Compound Info 
(R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C23H25N3O3
  1
1 Ki = 237 nM
CP0117972
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(quinolin-7-yloxy)-pyrrolidin-1-yl]-quinazoline
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C23H22N4O3
  1
1 Ki = 240 nM
CP0103707
 Compound Info 
(R)-4-[3-(3,4-Dimethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C22H25N3O5
  1
1 Ki = 260 nM
CP0117968
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C22H21N5O3
  1
1 Ki = 273 nM
CP0091873
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(6-methoxy-naphthalen-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C25H25N3O4
  1
1 Ki = 280 nM
CP0202707
 Compound Info 
(R)-4-[3-(Biphenyl-3-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C26H25N3O3
  1
1 Ki = 280 nM
CP0038124
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(7-methoxy-naphthalen-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C25H25N3O4
  1
1 Ki = 305 nM
CP0160129
 Compound Info 
(R)-4-[3-(4-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C22H25N3O4
  1
1 Ki = 328 nM
CP0156978
 Compound Info 
(R)-4-[3-(5-Chloro-pyrimidin-2-yloxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C18H18ClN5O3
  1
1 Ki = 332 nM
CP0117969
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(naphthalen-2-yloxy)-pyrrolidin-1-yl]-quinazoline
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C24H23N3O3
  1
1 Ki = 463 nM
CP0103708
 Compound Info 
(R)-4-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidin-3-yloxy]-benzonitrile
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C21H20N4O3
  1
1 Ki = 471 nM
CP0156977
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(pyridin-4-yloxy)-pyrrolidin-1-yl]-quinazoline
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C19H20N4O3
  1
1 Ki = 685 nM
CP0038128
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(pyridin-3-yloxy)-pyrrolidin-1-yl]-quinazoline
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C19H20N4O3
  1
1 Ki = 748 nM
CP0091870
 Compound Info 
(R)-4-[3-(4-tert-Butyl-phenoxy)-pyrrolidin-1-yl]-6,7-dimethoxy-quinazoline
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C24H29N3O3
  1
1 Ki = 1890 nM
CP0091868
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrrolidin-1-yl]-quinazoline
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C21H23N3O4
  1
1 Ki > 100 nM
CP0103710
 Compound Info 
(R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)-pyrrolidin-1-yl]-quinazoline
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C21H20F3N3O3
  1
1 Ki > 100 nM
Clinical Information about the Protein
Target 1 ( Phosphodiesterase 3B (PDE3B) )
Target Type Patented-recorded Target