General Information of the Protein
Protein ID
PT01679
Protein Name
17-beta-hydroxysteroid dehydrogenase type 2
Secondarily
Protein Name
20 alpha-hydroxysteroid dehydrogenase
E2DH
Estradiol 17-beta-dehydrogenase 2
Microsomal 17-beta-hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 9C member 2
Testosterone 17-beta-dehydrogenase
Gene Name
HSD17B2
Secondarily
Gene Name
EDH17B2
SDR9C2
Sequence
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Oxidoreductase
Function
Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity.
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Uniprot ID
Primary ID:
P37059

Secondarily ID:
B2R7T4
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Ensembl ID
ENSG00000086696
HGNC ID
HGNC:5211
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0390134
 Compound Info 
4-tert-butyl-N-(5-chloro-2-hydroxyphenyl)benzenesulfonamide
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C16H18ClNO3S
  1
1
IC50 = 800 nM
 Bioactivity Info 
   TI
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CP0544658
 Compound Info 
4-chloro-N-(3-hydroxyphenyl)-2,5-dimethylbenzenesulfonamide
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C14H14ClNO3S
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
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CP0410479
 Compound Info 
4-tert-butyl-N-(2-hydroxyphenyl)benzenesulfonamide
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C16H19NO3S
  1
1
IC50 = 1230 nM
 Bioactivity Info 
   TI
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CP0517948
 Compound Info 
4-tert-butyl-N-(2-hydroxy-5-phenylphenyl)benzenesulfonamide
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C22H23NO3S
  1
1
IC50 = 1250 nM
 Bioactivity Info 
   TI
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CP0396714
 Compound Info 
4-tert-butyl-N-(2-hydroxynaphthalen-1-yl)benzenesulfonamide
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C20H21NO3S
  1
1
IC50 = 2900 nM
 Bioactivity Info 
   TI
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CP0378933
 Compound Info 
(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
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C32H48O5
  1
1
IC50 = 3780 nM
 Bioactivity Info 
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CP0517949
 Compound Info 
4-tert-butyl-N-(2-hydroxy-5-methylphenyl)benzenesulfonamide
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C17H21NO3S
  1
1
IC50 = 4090 nM
 Bioactivity Info 
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CP0390133
 Compound Info 
4-tert-butyl-N-(2-hydroxy-4-methylphenyl)benzenesulfonamide
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C17H21NO3S
  1
1
IC50 = 4400 nM
 Bioactivity Info 
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CP0396713
 Compound Info 
N-(2-amino-4,5-dichlorophenyl)-4-tert-butylbenzenesulfonamide
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C16H18Cl2N2O2S
  1
1
IC50 = 4650 nM
 Bioactivity Info 
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CP0481529
 Compound Info 
4-tert-butyl-N-(2-hydroxy-3,5-dimethylphenyl)benzenesulfonamide
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C18H23NO3S
  1
1
IC50 = 5190 nM
 Bioactivity Info 
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CP0541576
 Compound Info 
N-(2-amino-5-chlorophenyl)-4-tert-butylbenzenesulfonamide
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C16H19ClN2O2S
  1
1
IC50 = 5580 nM
 Bioactivity Info 
   TI
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CP0897971
 Compound Info 
4-(2,4-dichlorophenyl)-2-hydroxy-3-(4-methoxy-3-methylbenzoyl)-5-(2-methoxyethyl)cyclopent-2-enone
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C23H22Cl2O5
  1
1
IC50 = 7440 nM
 Bioactivity Info 
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CP0433447
 Compound Info 
2-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-(methoxycarbonyl)-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yloxy)benzoic acid
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C38H52O6
  1
1
IC50 = 10300 nM
 Bioactivity Info 
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CP0433445
 Compound Info 
(R)-2-((2S,4aR,6S,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6,6a,6b,9,9,12a,14b-nonamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamido)-3-phenylpropanoic acid
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C41H59NO5
  1
1
IC50 = 23600 nM
 Bioactivity Info 
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CP0433448
 Compound Info 
4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentamethyl-7,11-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
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C29H42O6
  1
1
IC50 = 28300 nM
 Bioactivity Info 
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Cell Line ID: CL000197 , MG-63
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0352160
 Compound Info 
(4R,5R)-4-(2-fluorophenyl)-5-((S)-hydroxy(5-(pyridin-3-yl)thiophen-2-yl)methyl)-1-methylpyrrolidin-2-one
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C21H19FN2O2S
  1
1 IC50 = 30 nM