General Information of the Protein
Protein ID
PT01217
Protein Name
Bcl-2-like protein 1
Secondarily
Protein Name
Apoptosis regulator Bcl-X
Gene Name
BCL2L1
Secondarily
Gene Name
BCL2L
BCLX
Sequence
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Other ion channel
>
Miscellaneous ion channel
>
Bcl-2 family
Function
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
    Show/Hide
Uniprot ID
Primary ID:
Q07817

Secondarily ID:
E1P5L6
Q5CZ89
Q5TE65
Q92976
    Show/Hide
Ensembl ID
ENSG00000171552
HGNC ID
HGNC:992
Subcellular Location
Mitochondrion inner membrane
Mitochondrion outer membrane
Mitochondrion matrix
Cytoplasmic vesicle
Secretory vesicle
Synaptic vesicle membrane
Cytoplasm
Cytosol
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Nucleus membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000121 , FDC-P1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0112166
 Compound Info 
4-[4-[[2-(4-chlorophenyl)-6-[2-(dimethylamino)ethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C49H56ClF3N6O7S3
  1
1
IC50 = 33 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0068147
 Compound Info 
(R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide
   Show/Hide
C47H55ClF3N5O6S3
  1
1
IC50 = 60 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0281357
 Compound Info 
4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C45H47ClF3N5O6S3
  1
1
IC50 = 64 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0116815
 Compound Info 
4-[4-[[2-(4-chlorophenyl)-5-[2-(dimethylamino)ethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C49H56ClF3N6O7S3
  1
1
IC50 = 138 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0311689
 Compound Info 
4-[4-[[2-(4-chlorophenyl)-6-[2-(dimethylamino)-2-oxoethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C49H54ClF3N6O8S3
  1
1
IC50 = 226 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0264536
 Compound Info 
4-[4-[(R)-[2-(4-chlorophenyl)phenyl]sulfinyl]piperidin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C45H46ClF3N4O7S4
  1
1
IC50 = 1720 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0054087
 Compound Info 
2-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylpyrimidine-5-carboxamide
   Show/Hide
C43H45ClF3N7O6S3
  1
1
IC50 = 2090 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0115928
 Compound Info 
4-[4-[[2-(4-chlorophenyl)-5-[2-(dimethylamino)-2-oxoethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C49H54ClF3N6O8S3
  1
1
IC50 = 2090 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0115927
 Compound Info 
4-[4-[[2-(4-chlorophenyl)phenyl]methyl]-4-cyanopiperidin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C47H47ClF3N5O6S3
  1
1
IC50 = 2820 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000001 , Jurkat
 Cell Line Info 
Cell Line ID: CL000596 , U266B1
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0023982
 Compound Info 
4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]benzamide
   Show/Hide
C42H45ClN6O5S2
  19
1 EC50 < 10 nM
2 EC50 = 29.99 nM
3 IC50 = 0.5 nM
4 IC50 < 1 nM
5 IC50 = 3 nM
6 IC50 = 6 nM
7 IC50 = 14 nM
8 IC50 < 60 nM
9 IC50 = 64 nM
10 Kd = 0.13 nM
11 Kd = 0.37 nM
12 Ki < 0.5 nM
13 Ki < 1 nM
14 Ki <= 1 nM
15 Ki = 1 nM
16 Ki = 30 nM
17 Ki < 40 nM
18 Ki = 64 nM
19 Ki = 284 nM
CP0068147
 Compound Info 
(R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide
   Show/Hide
C47H55ClF3N5O6S3
  7
1 IC50 = 8.2 nM
2 Ki = 0.055 nM
3 Ki < 0.1 nM
4 Ki < 0.5 nM
5 Ki < 1 nM
6 Ki = 36 nM
7 Ki = 48 nM
CP0115927
 Compound Info 
4-[4-[[2-(4-chlorophenyl)phenyl]methyl]-4-cyanopiperidin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C47H47ClF3N5O6S3
  1
1 IC50 < 10 nM
CP0115928
 Compound Info 
4-[4-[[2-(4-chlorophenyl)-5-[2-(dimethylamino)-2-oxoethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C49H54ClF3N6O8S3
  1
1 IC50 = 10 nM
CP0116815
 Compound Info 
4-[4-[[2-(4-chlorophenyl)-5-[2-(dimethylamino)ethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C49H56ClF3N6O7S3
  1
1 IC50 = 10 nM
CP0311689
 Compound Info 
4-[4-[[2-(4-chlorophenyl)-6-[2-(dimethylamino)-2-oxoethoxy]phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C49H54ClF3N6O8S3
  1
1 IC50 = 10 nM
CP0264536
 Compound Info 
4-[4-[(R)-[2-(4-chlorophenyl)phenyl]sulfinyl]piperidin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C45H46ClF3N4O7S4
  1
1 IC50 = 11 nM
CP0281357
 Compound Info 
4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
   Show/Hide
C45H47ClF3N5O6S3
  1
1 IC50 = 16 nM
CP0054087
 Compound Info 
2-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylpyrimidine-5-carboxamide
   Show/Hide
C43H45ClF3N7O6S3
  1
1 IC50 = 39 nM
CP0107763
 Compound Info 
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
   Show/Hide
C13H9FO2
  1
1 Kd = 300000 nM
CP0033958
 Compound Info 
(Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid
   Show/Hide
C15H14BrNO3S2
  3
1 Ki = 2400 nM
2 Ki = 8700 nM
3 Ki = 10000 nM
CP0656007
 Compound Info 
ethyl 2-amino-6-(4-tert-butylphenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
   Show/Hide
C27H30N2O5
  1
1 Ki = 21700 nM
CP0708402
 Compound Info 
ethyl 2-amino-6-cyclopentyl-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
   Show/Hide
C22H26N2O5
  1
1 Ki = 36500 nM
CP0777127
 Compound Info 
ethyl 2-amino-6-phenyl-4-(1-cyano-2-ethoxy-2-oxoethyl)-4Hchromene-3-carboxylate
   Show/Hide
C23H22N2O5
  1
1 Ki = 52900 nM
CP0041746
 Compound Info 
4-[8-ethylsulfanyl-3-(4-hydroxyphenyl)-3-methyloctan-4-yl]phenol
   Show/Hide
C23H32O2S
  1
1 Ki = 58900 nM
CP0656008
 Compound Info 
ethyl 2-amino-6-n-propyl-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
   Show/Hide
C20H24N2O5
  1
1 Ki = 70700 nM
Clinical Information about the Protein
Target 1 ( Apoptosis regulator Bcl-xL (BCL-xL) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Myelofibrosis [ICD-11: 2A20.2]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 ABT-263
 Drug Info 
Phase 3
Myelofibrosis
Target 2 ( Bcl-x messenger RNA (BCL2L1 mRNA) )
Target Type Literature-reported Target