Protein Information

General Information of the Protein

Protein ID	PT00985
Protein Name	Cell division cycle 7-related protein kinase
Gene Name	CDC7
Secondarily Gene Name	CDC7L1
Sequence	MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Kinase > Protein Kinase > Other protein kinase group > Other protein kinase CDC7 family
Function	Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. Show/Hide
Uniprot ID	Primary ID: O00311 Secondarily ID: D3DT31 O00558 Q5T5U5 Show/Hide
Ensembl ID	ENSG00000097046
HGNC ID	HGNC:1745
Subcellular Location	Nucleus

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000034 , Caco-2

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0029051 Compound Info	8-chloro-2-[(2S)-pyrrolidin-2-yl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-one Show/Hide	C14H12ClN3O2	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS

Cell Line Info

Cell Line Info

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0182411 Compound Info	4-[3-(2-chloropyridin-3-yl)pyrrolo[3,2-c]pyridin-1-yl]pyrimidin-2-amine Show/Hide	C16H11ClN6	1
1	IC50 = 7 nM
CP0143129 Compound Info	1-(6-aminopyrimidin-4-yl)pyrrolo[2,3-b]pyridine-6-carbonitrile Show/Hide	C12H8N6	1
1	IC50 = 9 nM
CP0244947 Compound Info	4-[6-chloro-3-(2-chloropyridin-3-yl)pyrrolo[3,2-c]pyridin-1-yl]pyrimidin-2-amine Show/Hide	C16H10Cl2N6	1
1	IC50 = 30 nM
CP0131377 Compound Info	1-(2-aminopyrimidin-4-yl)indole-6-carbonitrile Show/Hide	C13H9N5	1
1	IC50 = 75 nM
CP0143166 Compound Info	4-(6-chloropyrrolo[3,2-c]pyridin-1-yl)pyrimidin-2-amine Show/Hide	C11H8ClN5	1
1	IC50 = 360 nM
CP0182408 Compound Info	4-indol-1-ylpyrimidin-2-amine Show/Hide	C12H10N4	1
1	IC50 = 4700 nM
CP0233225 Compound Info	1-(2-aminopyridin-4-yl)indole-6-carbonitrile Show/Hide	C14H10N4	1
1	IC50 = 9000 nM
CP0282146 Compound Info	4-pyrrolo[2,3-b]pyridin-1-ylpyrimidin-2-amine Show/Hide	C11H9N5	1
1	IC50 = 26700 nM
CP0179612 Compound Info	Simurosertib Show/Hide	C17H19N5OS	1
1	Kd = 0.424 nM
CP0238038 Compound Info	6-(5-methyl-1H-pyrazol-4-yl)-2-(pyrrolidin-1-ylmethyl)-3H-thieno[3,2-d]pyrimidin-4-one Show/Hide	C15H17N5OS	1
1	Kd = 0.541 nM
CP0202830 Compound Info	6-(5-methyl-1H-pyrazol-4-yl)-2-[(2S)-piperidin-2-yl]-3H-thieno[3,2-d]pyrimidin-4-one;dihydrochloride Show/Hide	C15H19Cl2N5OS	1
1	Kd = 1.96 nM

Clinical Information about the Protein

Target 1 ( CDC7-related kinase (CDC7) )

Target Type	Clinical trial Target
Disease	2 Target-related Diseases				2
1	Haematological malignancy [ICD-11: 2B33.Y]
2	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	BMS-863233	Drug Info	Phase 1/2	Haematological malignancy
2	TAK-931	Drug Info	Phase 1	Solid tumour/cancer