Protein Information

General Information of the Protein

Protein ID	PT00948
Protein Name	Prostaglandin E2 receptor EP2 subtype
Secondarily Protein Name	Prostanoid EP2 receptor
Gene Name	PTGER2
Sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Lipid-like ligand receptor (family A GPCR) > Prostanoid receptor
Function	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Show/Hide
Uniprot ID	Primary ID: P43116 Secondarily ID: D3DSC0 Q52LG8 Show/Hide
HGNC ID	HGNC:9594
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0415590 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H29NO4S2	1
1	EC50 = 0.068 nM Bioactivity Info	TI LI LO TS
CP0523517 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-4-hydroxy-4-methylnon-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H31NO4S2	1
1	EC50 = 0.086 nM Bioactivity Info	TI LI LO TS
CP0508797 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[[4-chloro-3-(trifluoromethyl)phenoxy]methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H19ClF3NO5S	1
1	EC50 = 0.11 nM Bioactivity Info	TI LI LO TS
CP0415589 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-8-fluoro-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H28FNO4S2	1
1	EC50 = 0.11 nM Bioactivity Info	TI LI LO TS
CP0401700 Compound Info	2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22ClNO5S	1
1	EC50 = 0.14 nM Bioactivity Info	TI LI LO TS
CP0401697 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3,5-dimethylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H24ClNO5S	1
1	EC50 = 0.17 nM Bioactivity Info	TI LI LO TS
CP0401696 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[(2,4,5-trichlorophenoxy)methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H18Cl3NO5S	1
1	EC50 = 0.2 nM Bioactivity Info	TI LI LO TS
CP0401695 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[(2,3,4-trichlorophenoxy)methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H18Cl3NO5S	1
1	EC50 = 0.21 nM Bioactivity Info	TI LI LO TS
CP0450782 Compound Info	2-[2-[(1R,5R)-2-oxo-5-[(E,4S)-7,7,7-trifluoro-4-hydroxy-4-methylhept-1-enyl]cyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H24F3NO4S2	1
1	EC50 = 0.37 nM Bioactivity Info	TI LI LO TS
CP0415587 Compound Info	2-[2-[(1R,2R)-2-[(E)-4-hydroxy-4-methylnon-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H31NO4S2	1
1	EC50 = 0.48 nM Bioactivity Info	TI LI LO TS
CP0377163 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[[2-(trifluoromethyl)phenoxy]methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H20F3NO5S	1
1	EC50 = 0.5 nM Bioactivity Info	TI LI LO TS
CP0498080 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(3,4-dichlorophenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H19Cl2NO5S	1
1	EC50 = 0.57 nM Bioactivity Info	TI LI LO TS
CP0182637 Compound Info	2-[2-[(4S)-4-[(E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxyprop-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H27FN2O5S2	1
1	EC50 = 0.67 nM Bioactivity Info	TI LI LO TS
CP0434442 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-ethylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H24ClNO5S	1
1	EC50 = 0.68 nM Bioactivity Info	TI LI LO TS
CP0401699 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22ClNO5S	1
1	EC50 = 0.69 nM Bioactivity Info	TI LI LO TS
CP0377164 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[[3-(trifluoromethyl)phenoxy]methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H20F3NO5S	1
1	EC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0377162 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[[3-(trifluoromethoxy)phenoxy]methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H20F3NO6S	1
1	EC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0519212 Compound Info	US9249085, I(al) Show/Hide	C25H26FNO4	1
1	EC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0513449 Compound Info	US9249085, I(ao) Show/Hide	C23H22FNO4	1
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0577760 Compound Info	US9249085, I(ag) Show/Hide	C24H23F2NO3	1
1	EC50 < 1 nM Bioactivity Info	TI LI LO TS
CP0415586 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-5-cyclopentyl-4-hydroxy-4-methylpent-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H31NO4S2	1
1	EC50 = 1.1 nM Bioactivity Info	TI LI LO TS
CP0847320 Compound Info	2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-(2-phenoxyethyl)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H23NO5S	1
1	EC50 = 1.4 nM Bioactivity Info	TI LI LO TS
CP0407431 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methoxyphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22ClNO6S	1
1	EC50 = 1.8 nM Bioactivity Info	TI LI LO TS
CP0055947 Compound Info	(15S)-prostaglandin E2 Show/Hide	C20H32O5	1
1	EC50 = 1.9 nM Bioactivity Info	TI LI LO TS
CP0414542 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-propan-2-ylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H26ClNO5S	1
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0493384 Compound Info	US9249085, I(ak) Show/Hide	C25H26FNO3	1
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0559816 Compound Info	US9249085, I(ad) Show/Hide	C23H20F3NO3	1
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0560381 Compound Info	US9249085, I(v) Show/Hide	C23H20F3NO3	1
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0577761 Compound Info	US9249085, I(aq) Show/Hide	C23H19F4NO3	1
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0407877 Compound Info	2-[2-[(1R,2R)-2-[(E,4R)-5-cyclopentyl-4-hydroxy-4-methylpent-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H31NO4S2	1
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0482357 Compound Info	2-[2-[(4S)-4-[(E)-4-hydroxy-4-methylnon-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H28N2O5S2	1
1	EC50 = 2.1 nM Bioactivity Info	TI LI LO TS
CP0434444 Compound Info	5-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]furan-2-carboxylic acid Show/Hide	C21H23ClO6	1
1	EC50 = 2.2 nM Bioactivity Info	TI LI LO TS
CP0414599 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(3,4-dimethylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H25NO5S	1
1	EC50 = 2.9 nM Bioactivity Info	TI LI LO TS
CP0493385 Compound Info	US9249085, I(aw) Show/Hide	C24H23F2NO3	1
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0494864 Compound Info	US9249085, I(am) Show/Hide	C24H23F2NO3	1
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0554660 Compound Info	US9249085, I(ap) Show/Hide	C24H24FNO4	1
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0562369 Compound Info	US9249085, I(ae) Show/Hide	C23H21F2NO3	1
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0577728 Compound Info	US9249085, I(aa) Show/Hide	C22H17F4NO3	1
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0380277 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(2-chlorophenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H20ClNO5S	1
1	EC50 = 3.3 nM Bioactivity Info	TI LI LO TS
CP0452553 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[(3-methylphenoxy)methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H23NO5S	1
1	EC50 = 3.6 nM Bioactivity Info	TI LI LO TS
CP0847318 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-3-phenoxy-1-propen-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C21H23NO5S	1
1	EC50 = 3.8 nM Bioactivity Info	TI LI LO TS
CP0380280 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chlorophenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H20ClNO5S	1
1	EC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0483476 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[[3-methyl-4-(trifluoromethyl)phenoxy]methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H22F3NO5S	1
1	EC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0862926 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-4-phenoxy-1-buten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C22H25NO5S	1
1	EC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0577727 Compound Info	US9249085, I(z) Show/Hide	C22H17F3N2O4	1
1	EC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0490967 Compound Info	US9249085, I(av) Show/Hide	C23H20F3NO3	1
1	EC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0576439 Compound Info	US9249085, I(af) Show/Hide	C24H23F2NO4	1
1	EC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0428589 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(3-fluorophenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H20FNO5S	1
1	EC50 = 5.4 nM Bioactivity Info	TI LI LO TS
CP0387603 Compound Info	2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-phenylbut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H22N2O4S2	1
1	EC50 = 5.6 nM Bioactivity Info	TI LI LO TS
CP0559818 Compound Info	US9249085, I(at) Show/Hide	C24H23F2NO3	1
1	EC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0380284 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(3-chlorophenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H20ClNO5S	1
1	EC50 = 6.5 nM Bioactivity Info	TI LI LO TS
CP0396047 Compound Info	2-[2-[(1R,2R)-2-[(E,4R)-4-hydroxy-4-methylnon-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H31NO4S2	1
1	EC50 = 6.8 nM Bioactivity Info	TI LI LO TS
CP0847319 Compound Info	2-{(2R,4aR,5R,6R,7aS)-5-[(4-fluorophenoxy)methyl]-6-hydroxyoctahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C19H20FNO5S	1
1	EC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0493383 Compound Info	US9249085, I(aj) Show/Hide	C24H24FNO3	1
1	EC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0847317 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C22H25NO6S	1
1	EC50 = 7.9 nM Bioactivity Info	TI LI LO TS
CP0494875 Compound Info	US9249085, I(ah) Show/Hide	C22H19F2NO4	1
1	EC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0559817 Compound Info	US9249085, I(ar) Show/Hide	C23H19F4NO3	1
1	EC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0576421 Compound Info	US9249085, I(u) Show/Hide	C22H18F3NO4	1
1	EC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0578098 Compound Info	US9249085, I(an) Show/Hide	C22H15F3N2O3	1
1	EC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0870958 Compound Info	2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-(3-phenoxypropyl)octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H25NO5S	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0379776 Compound Info	US9249085, I(m) Show/Hide	C22H18F3NO3	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0401702 Compound Info	2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-fluoro-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H21ClFNO4S	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0577762 Compound Info	US9249085, I(as) Show/Hide	C22H17F4NO3	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0380278 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-(phenoxymethyl)-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H21NO5S	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0424625 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[[4-(trifluoromethyl)phenoxy]methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H20F3NO5S	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0847322 Compound Info	2-{(2R,4aR,5R,6R,7aS)-6-hydroxy-5-[(1E)-5-phenoxy-1-penten-1-yl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid Show/Hide	C23H27NO5S	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0493381 Compound Info	US9249085, I(h) Show/Hide	C22H17F4NO3	1
1	EC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0380281 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[[4-(trifluoromethoxy)phenoxy]methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H20F3NO6S	1
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0578560 Compound Info	US9249085, I(w) Show/Hide	C21H14F5NO3	1
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0391092 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-oxazole-4-carboxylic acid Show/Hide	C20H22ClNO6	1
1	EC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0576440 Compound Info	US9249085, I(au) Show/Hide	C23H21F2NO3	1
1	EC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0519209 Compound Info	US9249085, I(p) Show/Hide	C21H16F3NO4	1
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0519211 Compound Info	US9249085, I(s) Show/Hide	C21H14F5NO3	1
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0566409 Compound Info	US9249085, I(t) Show/Hide	C23H20F3NO4	1
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0519210 Compound Info	US9249085, I(q) Show/Hide	C22H18F3NO4	1
1	EC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0554662 Compound Info	US9249085, I(as) (+ isomer) Show/Hide	C22H17F4NO3	1
1	EC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0578561 Compound Info	US9249085, I(ac) Show/Hide	C23H20F3NO3	1
1	EC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0401698 Compound Info	2-[(2R,4aR,5S,6S,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-methoxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H24ClNO5S	1
1	EC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0380283 Compound Info	2-[(2R,4aR,5S,6R,7aS)-5-[(2-fluorophenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C19H20FNO5S	1
1	EC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0489705 Compound Info	US9249085, I(l) Show/Hide	C21H15ClF3NO3	1
1	EC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0519205 Compound Info	US9249085, I(j) Show/Hide	C23H21F2NO3	1
1	EC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0377166 Compound Info	2-[(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[(4-methylphenoxy)methyl]-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H23NO5S	1
1	EC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0483309 Compound Info	US9249085, I(x) Show/Hide	C22H15F3N2O3	1
1	EC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0409741 Compound Info	2-[(2R,4aR,5R,6R,7aS)-6-hydroxy-5-(5-phenoxypentyl)-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]-1,3-thiazole-4-carboxylic acid Show/Hide	C23H29NO5S	1
1	EC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0560380 Compound Info	US9249085, I(b) Show/Hide	C21H15F4NO3	1
1	EC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0407879 Compound Info	2-[2-[(1R,2R)-2-[(E,4S)-4-hydroxy-4,7,7-trimethyloct-1-enyl]-5-oxocyclopentyl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H33NO4S2	1
1	EC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0519208 Compound Info	US9249085, I(o) Show/Hide	C21H15ClF3NO3	1
1	EC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0480081 Compound Info	US9249085, I(d) Show/Hide	C22H18F3NO3	1
1	EC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0513448 Compound Info	US9249085, I(ai) Show/Hide	C23H20F3NO3	1
1	EC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0554658 Compound Info	US9249085, I(r) Show/Hide	C21H15Cl2F2NO3	1
1	EC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0483310 Compound Info	US9249085, CP-544326 Show/Hide	C27H28N4O5S	1
1	EC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0545798 Compound Info	US9249085, I(ab) Show/Hide	C22H17F4NO3	1
1	EC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0519206 Compound Info	US9249085, I(n) Show/Hide	C21H15F4NO3	1
1	EC50 = 52 nM Bioactivity Info	TI LI LO TS
CP0407410 Compound Info	4-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]furan-2-carboxylic acid Show/Hide	C21H23ClO6	1
1	EC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0519204 Compound Info	US9249085, I(g) Show/Hide	C22H17F4NO3	1
1	EC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0379775 Compound Info	US9249085, I(c) Show/Hide	C22H18F3NO3	1
1	EC50 = 69 nM Bioactivity Info	TI LI LO TS
CP0489704 Compound Info	US9249085, I(k) Show/Hide	C21H15ClF3NO3	1
1	EC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0415588 Compound Info	2-[2-[(4S)-4-[(E)-5-cyclohexyl-4-hydroxy-4-methylpent-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C21H30N2O5S2	1
1	EC50 = 92 nM Bioactivity Info	TI LI LO TS
CP0577726 Compound Info	US9249085, I(i) Show/Hide	C22H18F3NO3	1
1	EC50 = 99 nM Bioactivity Info	TI LI LO TS
CP0497617 Compound Info	US9249085, I(a) Show/Hide	C21H17F2NO3	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0391098 Compound Info	4-[(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxy-2,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyran-2-yl]thiophene-2-carboxylic acid Show/Hide	C21H23ClO5S	1
1	EC50 = 114 nM Bioactivity Info	TI LI LO TS
CP0493382 Compound Info	US9249085, I(y) Show/Hide	C22H17F4NO3	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0545797 Compound Info	US9249085, I(e) Show/Hide	C21H16F3NO3	1
1	EC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0554657 Compound Info	US9249085, I(f) Show/Hide	C21H15F4NO4	1
1	EC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0407876 Compound Info	2-[2-[(4S,5S)-4-[(E)-5-cyclohexyl-4-hydroxy-4-methylpent-1-enyl]-5-methyl-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C22H32N2O5S2	1
1	EC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0858586 Compound Info	4-((2S,4aR,5R,6R,7aS)-6-hydroxy-5-((R,E)-3-hydroxy-4-phenoxybut-1-enyl)octahydrocyclopenta[b]pyran-2-yl)butanoic acid Show/Hide	C22H30O6	1
1	EC50 = 8900 nM Bioactivity Info	TI LI LO TS
CP0554661 Compound Info	US9249085, II(d) Show/Hide	C24H21F4NO3	1
1	EC50 > 300 nM Bioactivity Info	TI LI LO TS
CP0445340 Compound Info	7-{3,5-Dihydroxy-2-[3-hydroxy-4-(thiophen-2-ylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid Show/Hide	C20H32O5S2	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0374214 Compound Info	7-{2-[4-(3-Chloro-phenylsulfanyl)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid Show/Hide	C22H33ClO5S	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0402565 Compound Info	7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-5-phenyl-pentyl)-cyclopentyl]-heptanoic acid Show/Hide	C23H36O5	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0295469 Compound Info	(Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,5-dihydroxy-cyclopentyl}-hept-5-enoic acid Show/Hide	C22H29ClO6	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0432809 Compound Info	7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((S)-3-hydroxy-octyl)-cyclopentyl]-heptanoic acid Show/Hide	C20H38O5	1
1	IC50 = 4900 nM Bioactivity Info	TI LI LO TS
CP0402541 Compound Info	7-{(1R,2R,3R,5S)-2-[(R)-4-(3-Chloro-phenoxy)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid Show/Hide	C22H33ClO6	1
1	IC50 = 6700 nM Bioactivity Info	TI LI LO TS
CP0095751 Compound Info	(5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid Show/Hide	C20H34O5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0372737 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-m-tolylsulfanyl-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C23H36O5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0377752 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenylamino-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C22H35NO5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0395236 Compound Info	7-{2-[4-(3-Fluoro-phenylsulfanyl)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid Show/Hide	C22H33FO5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0432810 Compound Info	7-{3,5-Dihydroxy-2-[3-hydroxy-4-(thiazol-2-ylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid Show/Hide	C19H31NO5S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0433187 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenylsulfanyl-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C22H34O5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0438269 Compound Info	7-[3,5-Dihydroxy-2-(3-hydroxy-4-phenoxy-butyl)-cyclopentyl]-heptanoic acid Show/Hide	C22H34O6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0448266 Compound Info	7-{3,5-Dihydroxy-2-[3-hydroxy-4-(3-trifluoromethyl-phenylsulfanyl)-butyl]-cyclopentyl}-heptanoic acid Show/Hide	C23H33F3O5S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0427396 Compound Info	4-[(1S)-1-[[5-phenyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H21F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0427397 Compound Info	4-[(1S)-1-[[5-(cyclopenten-1-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H23F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0435681 Compound Info	US8686018, 107 Show/Hide	C22H18F5N3O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0438577 Compound Info	4-[(1S)-1-[[5-phenyl-3-[2-[3-(trifluoromethyl)phenoxy]ethyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C27H23F3N4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0438580 Compound Info	4-[(1S)-1-[[5-(furan-3-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C24H19F3N4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0473341 Compound Info	4-[(1S)-1-[[5-(5-methylthiophen-2-yl)-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C25H21F3N4O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0473342 Compound Info	4-[(1S)-1-[[5-thiophen-3-yl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C24H19F3N4O3S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0473344 Compound Info	4-[(1S)-1-[[5-[(E)-prop-1-enyl]-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H21F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0477510 Compound Info	4-[(1S)-1-[[5-prop-1-ynyl-3-[[4-(trifluoromethyl)phenyl]methyl]triazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C23H19F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0477511 Compound Info	4-[(1S)-1-[[3-[2-(4-fluorophenoxy)ethyl]-5-phenyltriazole-4-carbonyl]amino]ethyl]benzoic acid Show/Hide	C26H23FN4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0383448 Compound Info	5-[2-[5-chloro-2-[(4-fluorophenyl)methoxy]phenyl]-5-methylpyrrol-1-yl]-2-methylbenzoic acid Show/Hide	C26H21ClFNO3	1
1	IC50 < 3162.28 nM Bioactivity Info	TI LI LO TS
CP0059258 Compound Info	(Z)-7-{(1R,2R,3R,5R)-5-Chloro-2-[(E)-(S)-4-(1-ethyl-cyclobutyl)-4-hydroxy-but-1-enyl]-3-hydroxy-cyclopentyl}-hept-5-enoic acid Show/Hide	C22H35ClO4	1
1	Ki = 0.74 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000064 , Chem-1

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000076 , CHO/Galpha16

Cell Line Info

Cell Line ID: CL000516 , ECV-304

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000314 , HEK293T/17

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0055947 Compound Info	(15S)-prostaglandin E2 Show/Hide	C20H32O5	7
1	EC50 = 2.1 nM
2	IC50 = 2.2 nM
3	IC50 = 3.3 nM
4	IC50 = 37.7 nM
5	Ki = 1.7 nM
6	Ki = 4.9 nM
7	Ki = 38 nM
CP0182637 Compound Info	2-[2-[(4S)-4-[(E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxyprop-1-enyl]-2-oxo-1,3-oxazolidin-3-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid Show/Hide	C20H27FN2O5S2	1
1	EC50 = 2.9 nM
CP0059258 Compound Info	(Z)-7-{(1R,2R,3R,5R)-5-Chloro-2-[(E)-(S)-4-(1-ethyl-cyclobutyl)-4-hydroxy-but-1-enyl]-3-hydroxy-cyclopentyl}-hept-5-enoic acid Show/Hide	C22H35ClO4	2
1	EC50 = 3.8 nM
2	Ki = 3.3 nM
CP0092571 Compound Info	4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]benzoic acid Show/Hide	C22H17ClFNO4	1
1	IC50 = 709 nM
CP0663915 Compound Info	4-((S)-1-((R)-1-(2-phenoxyethyl)piperidine-2-carboxamido)ethyl)benzoic acid hydrochloride Show/Hide	C23H29ClN2O4	2
1	IC50 = 1630 nM
2	Ki = 1210 nM
CP0070143 Compound Info	2-(2-benzoyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acid Show/Hide	C20H18N2O3	1
1	IC50 > 10000 nM
CP0095751 Compound Info	(5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid Show/Hide	C20H34O5	1
1	IC50 > 100000 nM
CP0108218 Compound Info	(R)-2-(4-(4-chlorobenzyl)-5-acetyl-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid Show/Hide	C23H22ClNO5S	1
1	Ki = 230 nM
CP0174264 Compound Info	7-[(1R,2S)-2-[4-(1-hydroxyhexyl)phenyl]-5-oxocyclopentyl]heptanoic acid Show/Hide	C24H36O4	1
1	Ki = 240 nM
CP0041889 Compound Info	2-((R)-4-(4-chlorobenzyl)-5-(1-hydroxyethyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid Show/Hide	C23H24ClNO5S	1
1	Ki = 390 nM
CP0080235 Compound Info	4-(2-((R)-2-((S)-3-hydroxyhept-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoate Show/Hide	C20H27NO4	1
1	Ki = 425 nM
CP0144553 Compound Info	7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C19H33NO4	1
1	Ki = 4500 nM
CP0277044 Compound Info	(E)-3-{2-[(E)-3-(2-Benzyloxy-3-methyl-phenyl)-allyl]-phenyl}-acrylic acid Show/Hide	C26H24O3	1
1	Ki = 8100 nM
CP0179414 Compound Info	3-(2-((E)-3-(4-(benzyloxy)-3-methoxyphenyl)prop-1-enyl)phenyl)-N-(thiophen-2-ylsulfonyl)acrylamide Show/Hide	C30H27NO5S2	1
1	Ki = 8700 nM
CP0160939 Compound Info	(E)-3-[2-(3,4-dichlorophenyl)phenyl]-N-thiophen-2-ylsulfonylprop-2-enamide Show/Hide	C19H13Cl2NO3S2	1
1	Ki = 27000 nM
CP0257412 Compound Info	7-[(R)-2-((E)-3-Hydroxy-4-phenyl-but-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid Show/Hide	C21H29NO4	1
1	Ki = 31000 nM
CP0058712 Compound Info	N-[5-(2,6-dichlorophenyl)-1,3,4-thiadiazol-2-yl]-4-ethyl-2,3-dihydro-1,4-benzoxazine-6-carboxamide Show/Hide	C19H16Cl2N4O2S	1
1	Ki > 10000 nM
CP0045193 Compound Info	US8933098, 1 Show/Hide	C21H25N3O4	1
1	Ki > 18900 nM

Clinical Information about the Protein

Target 1 ( Prostaglandin E2 receptor EP2 (PTGER2) )

Target Type	Successful Target
Disease	11 Target-related Diseases				11
1	Erectile dysfunction [ICD-11: HA01.1]
2	Medical abortion [ICD-11: JA00.1Z]
3	Pulmonary arterial hypertension [ICD-11: BB01.0]
4	Organ transplant rejection [ICD-11: NE84]
5	Glaucoma/ocular hypertension [ICD-11: 9C61]
6	Stem cell engraftment [ICD-11: QB63.8]
7	Osteoporosis [ICD-11: FB83.0]
8	Endometriosis [ICD-11: GA10]
9	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
10	Coronary heart disease [ICD-11: BA80.Z]
11	Miscarriage [ICD-11: JA00.0]
Approved Drug(s)	6 Approved Drugs				6
1	Alprostadil	Drug Info	Approved	Erectile dysfunction
2	Dinoprostone	Drug Info	Approved	Medical abortion
3	Iloprost	Drug Info	Approved	Pulmonary arterial hypertension
4	Mycophenolate mofetil	Drug Info	Approved	Organ transplant rejection
5	Omidenepag isopropyl	Drug Info	Approved	Glaucoma/ocular hypertension
6	LAROPIPRANT	Drug Info	Phase 4	Coronary heart disease
Clinical Trial Drug(s)	5 Clinical Trial Drugs				5
1	16,16-dimethyl-PGE2	Drug Info	Phase 2	Stem cell engraftment
2	CP-533536	Drug Info	Phase 2	Osteoporosis
3	Taprenepag	Drug Info	Phase 2	Glaucoma/ocular hypertension
4	PF-4418948	Drug Info	Phase 1	Endometriosis
5	PGF2alpha	Drug Info	Clinical trial	Solid tumour/cancer
Discontinued Drug(s)	1 Discontinued Drug				1
1	ONO-8815Ly	Drug Info	Terminated	Miscarriage

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han