General Information of the Protein
Protein ID
PT00624
Protein Name
G protein-coupled receptor GPR35
Gene Name
GPR35
Secondarily
Gene Name
GPR35
Sequence
MNNTNCSILPWPAAVNHIFTIYLVLLLVLGLLLNGLALWVFCYRMHQWTETRVYMTNLAVADVCLLCSLPFVLYSLKYSTSDTPICQLSQGIYLVNRYMSISLVTAIAVDRYVAVRHPLRARELRSPRQAGAVCVALWVIVVTSLVLRWRLGIQEGGFCFSSQNRYNFSTTAFSLLGFYLPLAIVVFCSLQVVTALARRPATDVEQVEATQKATRMVWANLAVFIICFLPLHLILTVQVSLNLHTCAARNIFSRALTITAKLSDINCCLDAICYYYMAKEFQDASLRATASSTPHKSQDTQSLSLT
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Carboxylic acid receptor
>
Kynurenic acid receptor
Uniprot ID
Q33BM1
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Compound ID Compound Name Compound Formula
CP0037172
3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one
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C13H13N5O2
 1
1
EC50 = 61.1 nM
   TI
   LI
   LO
   TS
CP0748604
5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid (sodium) (disodium cromoglycate)
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C23H14Na2O11
 1
1
EC50 = 986 nM
   TI
   LI
   LO
   TS
CP0381005
6-bromo-8-[(6-methoxypyridine-3-carbonyl)amino]-4-oxochromene-2-carboxylic acid
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C17H11BrN2O6
 1
1
EC50 = 991 nM
   TI
   LI
   LO
   TS
CP0397163
6-bromo-8-[(2-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H12BrNO6
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0395587
8-(cyclohexanecarbonylamino)-4-oxochromene-2-carboxylic acid
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C17H17NO5
 1
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0389124
6-bromo-8-[(3,4-dimethoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C19H14BrNO7
 1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0380116
6-bromo-8-[(4-ethoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C19H14BrNO6
 1
1
EC50 = 1360 nM
   TI
   LI
   LO
   TS
CP0389119
6-bromo-8-[(4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H12BrNO6
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0380115
6-bromo-8-[(5-methoxypyridine-2-carbonyl)amino]-4-oxochromene-2-carboxylic acid
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C17H11BrN2O6
 1
1
EC50 = 1540 nM
   TI
   LI
   LO
   TS
CP0395601
6-fluoro-8-[(4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H12FNO6
 1
1
EC50 = 1760 nM
   TI
   LI
   LO
   TS
CP0397174
6-chloro-8-[(4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H12ClNO6
 1
1
EC50 = 1830 nM
   TI
   LI
   LO
   TS
CP0381004
8-(1,3-benzodioxole-5-carbonylamino)-6-bromo-4-oxochromene-2-carboxylic acid
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C18H10BrNO7
 1
1
EC50 = 2050 nM
   TI
   LI
   LO
   TS
CP0395590
6-bromo-8-[(3-methylbenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H12BrNO5
 1
1
EC50 = 2080 nM
   TI
   LI
   LO
   TS
CP0380137
6-chloro-8-[(3-methylbenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H12ClNO5
 1
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0395595
8-[(4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H13NO6
 1
1
EC50 = 2160 nM
   TI
   LI
   LO
   TS
CP0395733
6-bromo-8-[(4-cyanobenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H9BrN2O5
 1
1
EC50 = 2260 nM
   TI
   LI
   LO
   TS
CP0380130
8-[(3,4-dichlorobenzoyl)amino]-6-fluoro-4-oxochromene-2-carboxylic acid
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C17H8Cl2FNO5
 1
1
EC50 = 2650 nM
   TI
   LI
   LO
   TS
CP0397175
8-[(3-methylbenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H13NO5
 1
1
EC50 = 2750 nM
   TI
   LI
   LO
   TS
CP0404055
8-benzamido-6-bromo-4-oxochromene-2-carboxylic acid
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C17H10BrNO5
 1
1
EC50 = 2750 nM
   TI
   LI
   LO
   TS
CP0389127
8-benzamido-6-chloro-4-oxochromene-2-carboxylic acid
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C17H10ClNO5
 1
1
EC50 = 2840 nM
   TI
   LI
   LO
   TS
CP0395588
8-[(2,3-dichlorobenzoyl)amino]-6-fluoro-4-oxochromene-2-carboxylic acid
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C17H8Cl2FNO5
 1
1
EC50 = 3130 nM
   TI
   LI
   LO
   TS
CP0395600
6-chloro-8-[(4-nitrobenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C17H9ClN2O7
 1
1
EC50 = 3140 nM
   TI
   LI
   LO
   TS
CP0395586
6-bromo-8-[(3,4-dichlorobenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C17H8BrCl2NO5
 1
1
EC50 = 3250 nM
   TI
   LI
   LO
   TS
CP0381003
4-oxo-8-[(4-propoxybenzoyl)amino]chromene-2-carboxylic acid
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C20H17NO6
 1
1
EC50 = 3610 nM
   TI
   LI
   LO
   TS
CP0395599
6-bromo-8-[(2-chloro-4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
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C18H11BrClNO6
 1
1
EC50 = 4170 nM
   TI
   LI
   LO
   TS
CP0374969
8-[(3-methoxy-3-oxopropanoyl)amino]-4-oxochromene-2-carboxylic acid
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C14H11NO7
 1
1
EC50 = 6650 nM
   TI
   LI
   LO
   TS
CP0258522
4-[(Z)-[2-(2-fluorophenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]benzoic acid
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C17H11FN2O3S
 1
1
EC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0049039
4-hydroxyquinoline-2-carboxylic acid
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C10H7NO3
 1
1
EC50 = 66000 nM
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06259 G-protein coupled receptor 35 Mus musculus, Mouse