General Information of the Compound
Compound ID
CP0049039
Compound Name
4-hydroxyquinoline-2-carboxylic acid
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Synonyms
1,4-Dihydro-4-oxoquinoline-2-carboxylic acid
13593-94-7
2-Quinolinecarboxylic acid, 4-hydroxy-
4-Hydroxy-2-quinolincarboxylic acid
4-Hydroxy-2-quinolinecarboxylic acid
4-Hydroxyquinaldic acid
4-Hydroxyquinaldinic acid
4-Hydroxyquinoline-2-carboxylic acid
4-oxo-1,4-dihydroquinoline-2-carboxylic acid
4-oxo-1H-quinoline-2-carboxylic acid
492-27-3
CCRIS 4428
KYNA
Kinurenic acid
Kynurenate
Kynuronic acid
NSC 58973
NSC58973
Quinaldic acid, 4-hydroxy-
Quinurenic acid
TRANSTORINE
Transtorine
UNII-H030S2S85J
kynurenic acid
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Structure
Formula
C10H7NO3
Molecular Weight
189.17
Canonical SMILES
OC(=O)c1cc(O)c2ccccc2n1
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InChI
InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
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InChIKey
HCZHHEIFKROPDY-UHFFFAOYSA-N
CAS
492-27-3
Physicochemical Property
logP
1.6386
Rotatable Bonds
1
Heavy Atom Count
14
Polar Areas
70.42
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
14

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 3845
SID: 15091858
ChEMBL ID
CHEMBL299155
DrugBank ID
DB11937
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00624, G protein-coupled receptor GPR35
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 66000 nM
   TI
   LI
   LO
   TS
Protein ID: PT03308, G-protein coupled receptor 35
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 39200 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 39000 nM
Clinical Information about the Compound
Drug 1 ( TRANSTORINE )
Drug Name TRANSTORINE
Target(s)
Glutamate receptor ionotropic NMDA 1 (NMDAR1)
Inhibitor
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)
Inhibitor
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)
Inhibitor