General Information of the Protein
Protein ID
PT00619
Protein Name
11-beta-hydroxysteroid dehydrogenase 1
Secondarily
Protein Name
7-oxosteroid reductase
Corticosteroid 11-beta-dehydrogenase isozyme 1
Gene Name
HSD11B1
Sequence
MAFKKKYLPPLLGFFLAYYYYSANEEFRPEMLQGKKVIVTGASKGIGEQMAYHLAKMGAHVVVTARSKETLKKVVSHCLELGAASAHYIPGTMEDMTFAEQFVAKAGKLMGGLDMLILNHITNTSMNLFSGDIHLVRRSMEVNFLSYVVLSAAALPMLKQSNGSIVVVSSKAGKMSSPLVAPYSASKFALDGFFSSVRMEHSVTKVNVSITLCILGLINTDTAMKAVSGILSTVGASSKEECALEIIKGGALRQEEVYYDNSVWTAFLLGNPGRKILEFLSLRSYKLDKFINN
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Organism
Canis lupus familiaris, Dog, Canis familiaris
Protein Classification
Enzyme
Uniprot ID
Q5XX84
Ensembl ID
ENSG00000117594
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0450737
 Compound Info 
(5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one
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C15H19FN2O2S
  1
1
IC50 = 45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01107 11-beta-hydroxysteroid dehydrogenase 1 Homo sapiens, Human
 Protein Info 
PT01109 11-beta-hydroxysteroid dehydrogenase 1 Mus musculus, Mouse
 Protein Info 
PT03061 11-beta-hydroxysteroid dehydrogenase 1 Rattus norvegicus, Rat
 Protein Info