General Information of the Protein
Protein ID
PT00059
Protein Name
Envelope glycoprotein gp160
Secondarily
Protein Name
Glycoprotein 120
Gene Name
ENV
Sequence
MRVKGIRRNYQHLWRWGTMLLGMLMICSAKEQLWVTAYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPREVVMGNVTEEFNIWNNSMVEQMHEDIISLWDESLKPCVKLTPLCVTFNCTNYNGTRNGTTTEPPEVKNCTTKETGIKNCSFNIATSGVEDRFKKEYALLYTADIVQIDNSSINYTLIGCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGKGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEVVIRSDNFSDNAKTIIVQLKDPVVINCTRPNNNTRKGIRIGPGRTFYTTERIIGDIRQAHCNISRTQWNNTLRLIAAKLKKQFNNKTIIFRNSSGGDPEIVMHSFNCGGEFFYCNTTQLFNSTWVHNNTWVHNNTGNDTEEGTITLPCRIKQIINMWQEVGKAMYAPPIKGQIRCSSNITGLILTRDGGNTSSNNETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKARRRVVQREKRAVGMLGAMFLGFLGAAGSTMGAASLALTVQARQVVSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLGDQQLLGIWGCSGKLICTTAVPWNDSWSNKSLKYIWDNMTWMQWEKEIDIHVDTIYQLLEASQYQQEKNEKDLLELDKWESLWNWFDITNWLWYIKIFIMIVGGLIGLRIVFTVLSIVNRVRQGYSPLSLQTRLPTQRGPDRPEGIEEEGGERQRHIRSISEWILNNYPGRPAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQVFVESPPVLESGTKEECC
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Organism
Human immunodeficiency virus 1
Protein Classification
Surface antigen
Uniprot ID
Q6QLK5
Subcellular Location
Cell membrane
Cell membrane
Endosome membrane
Endosome membrane
Host cell membrane
Host cell membrane
Host endosome membrane
Host endosome membrane
Membrane
Membrane
Virion membrane
Virion membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000442 , Cf2Th-CCR5
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0567916
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[(1R,2R,3S)-2-[(diaminomethylideneamino)methyl]-3-[(3S)-3,4-dihydroxybutyl]-5-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]oxamide;2,2,2-trifluoroacetic acid
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C29H34ClF7N6O8
  1
1
IC50 = 910 nM
 Bioactivity Info 
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CP0569688
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[(1R,2R,3S)-2-[(diaminomethylideneamino)methyl]-3-(3,4-dihydroxybutyl)-6-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]oxamide;2,2,2-trifluoroacetic acid
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C29H34ClF7N6O8
  1
1
IC50 = 960 nM
 Bioactivity Info 
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CP0569168
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[(1R,2R,3S)-2-[(diaminomethylideneamino)methyl]-3-[(3R)-3,4-dihydroxybutyl]-5-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]oxamide;2,2,2-trifluoroacetic acid
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C29H34ClF7N6O8
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0491422
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[(1R,2R,3S)-2-[(diaminomethylideneamino)methyl]-3-(3-hydroxypropyl)-6-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]oxamide;2,2,2-trifluoroacetic acid
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C28H32ClF7N6O7
  1
1
IC50 = 2050 nM
 Bioactivity Info 
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CP0569557
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[(1R,2R,3S)-2-[(diaminomethylideneamino)methyl]-3-[(3S)-3,4-dihydroxybutyl]-6-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]oxamide;2,2,2-trifluoroacetic acid
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C29H34ClF7N6O8
  1
1
IC50 = 2220 nM
 Bioactivity Info 
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CP0539197
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[(1R,2R,3S)-2-[(diaminomethylideneamino)methyl]-3-(3,4-dihydroxybutyl)-5-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]oxamide;2,2,2-trifluoroacetic acid
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C29H34ClF7N6O8
  3
1
IC50 = 3320 nM
 Bioactivity Info 
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2
IC50 = 20600 nM
 Bioactivity Info 
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3
IC50 = 98900 nM
 Bioactivity Info 
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CP0573541
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[(1R,2R,3S)-2-[(diaminomethylideneamino)methyl]-3-(4-hydroxy-3-oxobutyl)-5-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]oxamide;2,2,2-trifluoroacetic acid
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C29H32ClF7N6O8
  2
1
IC50 = 3350 nM
 Bioactivity Info 
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2
IC50 > 100000 nM
 Bioactivity Info 
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CP0571585
 Compound Info 
N-[(1R,2R,3S)-3-but-3-enyl-2-[(diaminomethylideneamino)methyl]-5-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]-N'-(4-chloro-3-fluorophenyl)oxamide;2,2,2-trifluoroacetic acid
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C29H32ClF7N6O6
  1
1
IC50 = 7400 nM
 Bioactivity Info 
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CP0568484
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[(1R,2R,3S)-2-[(diaminomethylideneamino)methyl]-3-(3-hydroxypropyl)-5-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]oxamide;2,2,2-trifluoroacetic acid
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C28H32ClF7N6O7
  1
1
IC50 = 7700 nM
 Bioactivity Info 
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CP0569689
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[(1R,2R)-2-[(diaminomethylideneamino)methyl]-5-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]oxamide;2,2,2-trifluoroacetic acid
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C25H26ClF7N6O6
  1
1
IC50 = 95900 nM
 Bioactivity Info 
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CP0572460
 Compound Info 
N-[(1R,2R,3S)-3-butyl-2-[(diaminomethylideneamino)methyl]-5-(methylaminomethyl)-2,3-dihydro-1H-inden-1-yl]-N'-(4-chloro-3-fluorophenyl)oxamide;2,2,2-trifluoroacetic acid
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C29H34ClF7N6O6
  1
1
IC50 > 100000 nM
 Bioactivity Info 
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Cell Line ID: CL000599 , TZM-bl
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT03571 Envelope glycoprotein gp160 Human immunodeficiency virus type 1 group M subtype B (isolate HXB2), HIV-1
 Protein Info