General Information of the Protein
Protein ID
PT03571
Protein Name
Envelope glycoprotein gp160
Secondarily
Protein Name
Env polyprotein
Glycoprotein 120
Glycoprotein 41
Gene Name
ENV
Sequence
MRVKEKYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNTNSSSGRMIMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYKLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDNAKTIIVQLNTSVEINCTRPNNNTRKRIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNNTLKQIASKLREQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRIKQIINMWQKVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLICTTAVPWNASWSNKSLEQIWNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTHLPTPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAIRHIPRRIRQGLERILL
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Organism
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2), HIV-1
Protein Classification
Surface antigen
Function
Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.
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Uniprot ID
Primary ID:
P04578

Secondarily ID:
O09779
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Subcellular Location
Virion membrane
Host cell membrane
Host endosome membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000442 , Cf2Th-CCR5
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0144831
 Compound Info 
N-(5-azaspiro[3.5]nonan-8-yl)-N'-(4-chloro-3-fluorophenyl)oxamide
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C16H19ClFN3O2
  2
1
IC50 = 9300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 86900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0282807
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide
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C17H23ClFN3O2
  2
1
IC50 = 9600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 29100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0282780
 Compound Info 
N'-(4-chloro-3-fluorophenyl)-N-[2-[(2S,6R)-2,6-dimethylpiperidin-1-yl]ethyl]oxamide
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C17H23ClFN3O2
  2
1
IC50 = 34500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 83200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000291 , HL2/3
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0067240
 Compound Info 
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-carboxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoic acid
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C193H305N57O62
  1
1 IC50 = 67.5 nM
CP0664133
 Compound Info 
WEAWDRAIAEYAARIEALIRAAQEQQEKNEAALREL
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C185H291N55O58
  1
1 IC50 = 77.4 nM
Clinical Information about the Protein
Target 1 ( Human immunodeficiency virus Envelope messenger RNA (HIV env mRNA) )
Target Type Successful Target
Target 2 ( Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) )
Target Type Clinical trial Target