Brief Information of the Cell Line and Protein
Cell Line ID: CL000654 , NCI-H727
Synonyms
H727
H-727
NCIH727
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1584
Protein ID: PT04417 , Son of sevenless homolog 1
Gene Name SOS1
Organism Homo sapiens, Human
Protein Classification Unclassified protein
Uniprot ID Q07889
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000654  Protein ID: PT04417
 
Compound ID Compound Name Compound Formula
CP0415807
6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpiperazin-1-yl)-2-piperazin-1-ylbenzimidazole
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C25H32ClFN6
 1
1
EC50 = 7300 nM
   TI
   LI
   LO
   TS
CP0519766
[(2S)-1-[6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-ylbenzimidazol-4-yl]pyrrolidin-2-yl]methanamine
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C25H32ClFN6
 1
1
EC50 = 7300 nM
   TI
   LI
   LO
   TS
CP0387111
6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpiperazin-1-yl)benzimidazole
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C26H32ClFN6
 1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0387110
5-[6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]benzimidazol-4-yl]-4-methylpyrimidin-2-amine
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C26H27ClFN7
 1
1
EC50 = 13400 nM
   TI
   LI
   LO
   TS
CP0429954
6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-yl-4-(4-propan-2-ylpyrimidin-5-yl)benzimidazole
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C27H30ClFN6
 1
1
EC50 = 13900 nM
   TI
   LI
   LO
   TS
CP0410993
6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpyrimidin-5-yl)-2-piperazin-1-ylbenzimidazole
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C25H26ClFN6
 1
1
EC50 = 14500 nM
   TI
   LI
   LO
   TS
CP0405322
6-chloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-ylbenzimidazole
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C25H28ClFN6
 1
1
EC50 = 15600 nM
   TI
   LI
   LO
   TS
CP0410994
6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-4-(4-methylpyrimidin-5-yl)benzimidazole
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C26H26ClFN6
 1
1
EC50 = 15700 nM
   TI
   LI
   LO
   TS
CP0387118
1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethylbenzimidazol-2-amine
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C16H15ClFN3
 1
1
EC50 = 18700 nM
   TI
   LI
   LO
   TS
CP0410992
6-chloro-4-(2-chlorophenyl)-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]benzimidazole
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C27H25Cl2FN4
 1
1
EC50 = 19700 nM
   TI
   LI
   LO
   TS
CP0387112
6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-4-(3,5-dimethyl-1H-pyrazol-4-yl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]benzimidazole
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C26H28ClFN6
 1
1
EC50 = 21100 nM
   TI
   LI
   LO
   TS
CP0387115
6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-ylbenzimidazole
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C20H22ClFN4
 1
1
EC50 = 21200 nM
   TI
   LI
   LO
   TS
CP0405324
5-[6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluorophenyl)methyl]benzimidazol-4-yl]-4-methylpyrimidin-2-amine
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C24H23ClFN7
 1
1
EC50 = 27500 nM
   TI
   LI
   LO
   TS
CP0405321
1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-2-piperazin-1-ylbenzimidazole
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C20H22ClFN4
 1
1
EC50 = 29100 nM
   TI
   LI
   LO
   TS
CP0387116
6-chloro-4-(2-chlorophenyl)-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-piperazin-1-ylbenzimidazole
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C26H25Cl2FN4
 1
1
EC50 = 36800 nM
   TI
   LI
   LO
   TS
CP0387117
6-chloro-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1-[(4-fluorophenyl)methyl]-4-(4-methylpyrimidin-5-yl)benzimidazole
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C24H22ClFN6
 1
1
EC50 = 42500 nM
   TI
   LI
   LO
   TS
CP0387114
1-[(3-chloro-4-fluorophenyl)methyl]-2-piperazin-1-ylbenzimidazole
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C18H18ClFN4
 1
1
EC50 = 51400 nM
   TI
   LI
   LO
   TS