Brief Information of the Cell Line and Protein
Cell Line ID: CL000152 , Granta-519
 Cell Line Info 
Synonyms
GRANTA-519
Granta 519
Granta519
GRANTA519
G-519
G519
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1818
Protein ID: PT03087 , Protein arginine N-methyltransferase 5
 Protein Info 
Gene Name PRMT5
Organism Homo sapiens, Human
Protein Classification Epigenetic regulator
Uniprot ID O14744
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000152
 Cell Line Info 
 Protein ID: PT03087
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0003767
 Compound Info 
(2R,3S,4R,5R)-2-[(R)-(4-chlorophenyl)-hydroxymethyl]-5-(5-hydroxy-3,6,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2,7,11-tetraen-10-yl)oxolane-3,4-diol
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C19H19ClN4O5
  1
1
IC50 = 12 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0006662
 Compound Info 
2-[[7-[(2R,3R,4S,5R)-5-[(R)-(4-chlorophenyl)-hydroxymethyl]-3,4-dihydroxyoxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]acetaldehyde
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C19H19ClN4O5
  1
1
IC50 = 22 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0006098
 Compound Info 
1-[[7-[(2R,3R,4S,5R)-5-[(R)-(3,4-difluorophenyl)-hydroxymethyl]-3,4-dihydroxyoxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]propan-2-one
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C20H20F2N4O5
  1
1
IC50 = 43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0014642
 Compound Info 
(2R,3S,4R,5R)-2-[(R)-(4-chlorophenyl)-hydroxymethyl]-5-(10-hydroxy-5,7,9,13-tetrazatricyclo[7.4.0.02,6]trideca-1(13),2(6),3,7-tetraen-5-yl)oxolane-3,4-diol;hydrochloride
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C20H22Cl2N4O5
  1
1
IC50 = 158 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0003451
 Compound Info 
(2R,3S,4R,5R)-2-[(R)-(4-chlorophenyl)-hydroxymethyl]-5-[4-(2,2-dimethoxyethylamino)pyrrolo[2,3-d]pyrimidin-7-yl]oxolane-3,4-diol
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C21H25ClN4O6
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0008189
 Compound Info 
(2R,3S,4R,5R)-2-[(R)-(4-chlorophenyl)-hydroxymethyl]-5-(5-methoxy-3,6,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2,7,11-tetraen-10-yl)oxolane-3,4-diol
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C20H21ClN4O5
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS