General Information of the Compound
Compound ID
CP0003767
Compound Name
(2R,3S,4R,5R)-2-[(R)-(4-chlorophenyl)-hydroxymethyl]-5-(5-hydroxy-3,6,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1(9),2,7,11-tetraen-10-yl)oxolane-3,4-diol
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Structure
Formula
C19H19ClN4O5
Molecular Weight
418.837
Canonical SMILES
O[C@@H]([C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc2C3=NCC(O)N3C=Nc12)c1ccc(Cl)cc1
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InChI
InChI=1S/C19H19ClN4O5/c20-10-3-1-9(2-4-10)13(26)16-14(27)15(28)19(29-16)23-6-5-11-17-21-7-12(25)24(17)8-22-18(11)23/h1-6,8,12-16,19,25-28H,7H2/t12?,13-,14+,15-,16-,19-/m1/s1
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InChIKey
LTPABOINPMWTKU-BHUSIORFSA-N
Physicochemical Property
logP
0.5483
Rotatable Bonds
3
Heavy Atom Count
29
Polar Areas
123.04
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 135308826
ChEMBL ID
CHEMBL4518534
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03087, Protein arginine N-methyltransferase 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000152 Granta-519 Homo sapiens (Human)  1
1
IC50 = 12 nM
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