Brief Information of the Cell Line and Protein
Cell Line ID: CL000518 , SW48
Synonyms
SW-48
SW 48
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1724
Protein ID: PT02896 , Tryptophan 2,3-dioxygenase
Gene Name TDO2
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P48775
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000518  Protein ID: PT02896
 
Compound ID Compound Name Compound Formula
CP0238103
(1S,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1,2,3,4-tetrahydronaphthalen-1-ol
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C20H18N2O
 1
1
EC50 = 32 nM
   TI
   LI
   LO
   TS
CP0909091
(1S,2S)-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)-1-phenylpropan-1-ol
   Show/Hide
C19H18N2O
 1
1
EC50 <= 32 nM
   TI
   LI
   LO
   TS
CP0552205
(5S)-5-cyclohexyl-5H-imidazo[5,1-a]isoindole
   Show/Hide
C16H18N2
 1
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
CP0225409
(7S,8S)-8-hydroxy-7-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydronaphthalene-2-carboxamide
   Show/Hide
C21H19N3O2
 1
1
EC50 = 35 nM
   TI
   LI
   LO
   TS
CP0476298
(1R,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]cyclobutan-1-ol
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C14H14N2O
 1
1
EC50 = 36 nM
   TI
   LI
   LO
   TS
CP0387094
(1S,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-7-methylsulfonyl-1,2,3,4-tetrahydronaphthalen-1-ol
   Show/Hide
C21H20N2O3S
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0537143
(5S,6S)-6-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydroisoquinolin-5-ol
   Show/Hide
C19H17N3O
 1
1
EC50 = 48 nM
   TI
   LI
   LO
   TS
CP0394145
(7S,8S)-7-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydroisoquinolin-8-ol
   Show/Hide
C19H17N3O
 1
1
EC50 = 50 nM
   TI
   LI
   LO
   TS
CP0438720
(1R,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]cyclohexan-1-ol
   Show/Hide
C16H18N2O
 1
1
EC50 = 50 nM
   TI
   LI
   LO
   TS
CP0165570
(4S,5S)-5-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-4,5,6,7-tetrahydro-2,1,3-benzoxadiazol-4-ol
   Show/Hide
C16H14N4O2
 1
1
EC50 = 54 nM
   TI
   LI
   LO
   TS
CP0387082
(7S,8S)-8-hydroxy-7-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile
   Show/Hide
C21H17N3O
 1
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
CP0519131
(1R,2S)-1-cyclohexyl-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]propan-1-ol
   Show/Hide
C19H24N2O
 1
1
EC50 = 62 nM
   TI
   LI
   LO
   TS
CP0462096
(1S,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-6-methylsulfonyl-1,2,3,4-tetrahydronaphthalen-1-ol
   Show/Hide
C21H20N2O3S
 1
1
EC50 = 65 nM
   TI
   LI
   LO
   TS
CP0482242
(1R,2S)-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]cyclopentan-1-ol
   Show/Hide
C15H16N2O
 1
1
EC50 = 70 nM
   TI
   LI
   LO
   TS
CP0520089
(1S)-2-[(5R)-5H-imidazo[5,1-a]isoindol-5-yl]-2-methyl-1-(1,3-oxazol-2-yl)propan-1-ol
   Show/Hide
C17H17N3O2
 1
1
EC50 = 71 nM
   TI
   LI
   LO
   TS
CP0165569
(3S,4S)-4-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]oxan-3-ol
   Show/Hide
C15H16N2O2
 1
1
EC50 = 72 nM
   TI
   LI
   LO
   TS
CP0073699
4-(4-fluoropyrazol-1-yl)-1,2-oxazol-5-amine
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C6H5FN4O
 1
1
EC50 = 77 nM
   TI
   LI
   LO
   TS
CP0080260
4-phenyl-1,2-oxazol-5-amine
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C9H8N2O
 1
1
EC50 = 85 nM
   TI
   LI
   LO
   TS
CP0165568
(3S,4S)-4-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1-methylsulfonylpiperidin-3-ol
   Show/Hide
C16H19N3O3S
 1
1
EC50 = 87 nM
   TI
   LI
   LO
   TS
CP0234045
4-thiophen-3-yl-1,2-oxazol-5-amine
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C7H6N2OS
 1
1
EC50 = 99 nM
   TI
   LI
   LO
   TS
CP0230210
(4S,5S)-5-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-4-ol
   Show/Hide
C17H16N4O
 1
1
EC50 = 130 nM
   TI
   LI
   LO
   TS
CP0327837
(1S,2S)-7-dimethylphosphoryl-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1,2,3,4-tetrahydronaphthalen-1-ol
   Show/Hide
C22H23N2O2P
 1
1
EC50 = 130 nM
   TI
   LI
   LO
   TS
CP0222808
4-(4-fluorophenyl)-1,2-oxazol-5-amine
   Show/Hide
C9H7FN2O
 1
1
EC50 = 210 nM
   TI
   LI
   LO
   TS
CP0519130
(3R,4R)-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]oxan-4-ol
   Show/Hide
C15H16N2O2
 1
1
EC50 = 210 nM
   TI
   LI
   LO
   TS
CP0080261
4-pyrazol-1-yl-1,2-oxazol-5-amine
   Show/Hide
C6H6N4O
 1
1
EC50 = 230 nM
   TI
   LI
   LO
   TS
CP0225530
4-(3-chlorophenyl)-1,2-oxazol-5-amine
   Show/Hide
C9H7ClN2O
 1
1
EC50 = 250 nM
   TI
   LI
   LO
   TS
CP0564188
(1S)-1-cyclohexyl-2-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]ethanol
   Show/Hide
C18H22N2O
 1
1
EC50 = 250 nM
   TI
   LI
   LO
   TS
CP0559942
4-(4-methylpyrazol-1-yl)-1,2-oxazol-5-amine
   Show/Hide
C7H8N4O
 1
1
EC50 = 340 nM
   TI
   LI
   LO
   TS
CP0080251
4-cyclopentyl-1,2-oxazol-5-amine
   Show/Hide
C8H12N2O
 1
1
EC50 = 360 nM
   TI
   LI
   LO
   TS
CP0519132
(4S,5S)-5-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1-methyl-4,5,6,7-tetrahydroindazol-4-ol
   Show/Hide
C18H18N4O
 1
1
EC50 = 380 nM
   TI
   LI
   LO
   TS
CP0364637
N-methyl-4-phenyl-1,2-oxazol-5-amine
   Show/Hide
C10H10N2O
 1
1
EC50 = 670 nM
   TI
   LI
   LO
   TS
CP0080253
4-(3-methylpyrazol-1-yl)-1,2-oxazol-5-amine
   Show/Hide
C7H8N4O
 1
1
EC50 = 810 nM
   TI
   LI
   LO
   TS
CP0346370
4-thiophen-2-yl-1,2-oxazol-5-amine
   Show/Hide
C7H6N2OS
 1
1
EC50 = 810 nM
   TI
   LI
   LO
   TS
CP0534912
4-pyridin-2-yl-1,2-oxazol-5-amine
   Show/Hide
C8H7N3O
 1
1
EC50 = 820 nM
   TI
   LI
   LO
   TS
CP0073693
4-(4-chlorophenyl)-1,2-oxazol-5-amine
   Show/Hide
C9H7ClN2O
 1
1
EC50 = 950 nM
   TI
   LI
   LO
   TS
CP0521484
4-pyridin-3-yl-1,2-oxazol-5-amine
   Show/Hide
C8H7N3O
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0537144
(3S,4S)-4-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-1-methylpiperidin-3-ol
   Show/Hide
C16H19N3O
 1
1
EC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0230444
4-cyclohexyl-1,2-oxazol-5-amine
   Show/Hide
C9H14N2O
 1
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0429359
4-(3-methoxyphenyl)-1,2-oxazol-5-amine
   Show/Hide
C10H10N2O2
 1
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0387095
1-[(3S,4S)-3-hydroxy-4-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]piperidin-1-yl]ethanone
   Show/Hide
C17H19N3O2
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0394144
(7S,8S)-7-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-ol
   Show/Hide
C16H15N5O
 1
1
EC50 = 7400 nM
   TI
   LI
   LO
   TS
CP0210888
3-methyl-4-phenyl-1,2-oxazol-5-amine
   Show/Hide
C10H10N2O
 1
1
EC50 = 9700 nM
   TI
   LI
   LO
   TS
CP0466617
(4-phenyl-1,2-oxazol-5-yl)methanol
   Show/Hide
C10H9NO2
 1
1
EC50 = 18000 nM
   TI
   LI
   LO
   TS
CP0210992
2-methyl-4-phenylpyrazol-3-amine
   Show/Hide
C10H11N3
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0222812
4-phenyl-1,2-thiazol-5-amine
   Show/Hide
C9H8N2S
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0248178
5-phenyl-1,2-oxazol-4-amine
   Show/Hide
C9H8N2O
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0248179
3-phenyltriazol-4-amine
   Show/Hide
C8H8N4
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0346369
4-phenyl-1,2-oxazole
   Show/Hide
C9H7NO
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0354580
4-phenyl-1,2-oxazole-5-carboxamide
   Show/Hide
C10H8N2O2
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0354582
4-phenyl-1H-pyrazol-5-amine
   Show/Hide
C9H9N3
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0364638
4-phenyl-1,2,4-triazol-3-amine
   Show/Hide
C8H8N4
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0469397
5-phenylthiadiazol-4-amine
   Show/Hide
C8H7N3S
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0473820
4-phenylthiadiazol-5-amine
   Show/Hide
C8H7N3S
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0534913
5-phenyl-1,2-thiazol-4-amine
   Show/Hide
C9H8N2S
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0543217
N-methyl-4-phenyl-1,2-oxazole-5-carboxamide
   Show/Hide
C11H10N2O2
 1
1
EC50 > 25000 nM
   TI
   LI
   LO
   TS
CP0414359
3,4-difluoro-N-[3-[(2S)-1-(4-fluoroanilino)-1-oxopropan-2-yl]-1-bicyclo[1.1.1]pentanyl]benzamide
   Show/Hide
C21H19F3N2O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0525373
3-chloro-N-[3-[(2S)-1-(4-fluoroanilino)-1-oxopropan-2-yl]-1-bicyclo[1.1.1]pentanyl]benzamide
   Show/Hide
C21H20ClFN2O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS