Brief Information of the Cell Line and Protein
Cell Line ID: CL000752 , PBMC iPSC #1
Category Induced pluripotent stem cell
Organism
Homo sapiens (Human)
Protein ID: PT02663 , Nuclear receptor ROR-gamma
Gene Name RORC
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID P51449
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000752  Protein ID: PT02663
 
Compound ID Compound Name Compound Formula
CP0543989
2-[[4-chloro-2-(trifluoromethyl)phenyl]methyl]-N-[(4-ethylsulfonylphenyl)methyl]-1-(2-fluoroethyl)indole-5-carboxamide
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C28H25ClF4N2O3S
 1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
CP0551554
2-[(2-ethylphenyl)methyl]-N-[(4-ethylsulfonylphenyl)methyl]-1-propan-2-ylindole-5-carboxamide
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C30H34N2O3S
 1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
CP0576937
2-[[4-chloro-2-(trifluoromethyl)phenyl]methyl]-N-[(4-ethylsulfonylphenyl)methyl]-1-propan-2-ylindole-5-carboxamide
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C29H28ClF3N2O3S
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0543990
N-[(4-ethylsulfonylphenyl)methyl]-2-[[4-fluoro-2-(trifluoromethyl)phenyl]methyl]-1-propan-2-ylindole-5-carboxamide
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C29H28F4N2O3S
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0551553
N-[(4-ethylsulfonylphenyl)methyl]-1-propan-2-yl-2-[[3-(trifluoromethyl)phenyl]methyl]indole-5-carboxamide
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C29H29F3N2O3S
 1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CP0574891
2-[[4-chloro-2-(trifluoromethyl)phenyl]methyl]-1-cyclopropyl-N-[(4-ethylsulfonylphenyl)methyl]indole-5-carboxamide
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C29H26ClF3N2O3S
 1
1
EC50 = 32 nM
   TI
   LI
   LO
   TS
CP0546846
N-[(4-ethylsulfonylphenyl)methyl]-1-propan-2-yl-2-[[2-(trifluoromethyl)phenyl]methyl]indole-5-carboxamide
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C29H29F3N2O3S
 1
1
EC50 = 93 nM
   TI
   LI
   LO
   TS
CP0576650
N-[(4-ethylsulfonylphenyl)methyl]-1-propan-2-yl-2-[[4-(trifluoromethyl)phenyl]methyl]indole-5-carboxamide
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C29H29F3N2O3S
 1
1
EC50 = 109 nM
   TI
   LI
   LO
   TS