Brief Information of the Cell Line and Protein
Cell Line ID: CL000001 , Jurkat
Synonyms
JURKAT
JM
JM-Jurkat
Jurkat-FHCRC
Jurkat FHCRC
FHCRC-11
FHCRC subclone 11
FCCH1024
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0065
Protein ID: PT02509 , G-protein coupled bile acid receptor 1
Gene Name GPBAR1
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q8TDU6
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000001  Protein ID: PT02509
 
Compound ID Compound Name Compound Formula
CP0121520
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-[4-(oxetan-3-yl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
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C27H32F3N7O2
 1
1
EC50 = 1 nM
   TI
   LI
   LO
   TS
CP0157850
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[4-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxamide
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C25H30F3N7O
 1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
CP0121522
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
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C25H30F3N7O
 1
1
EC50 = 3 nM
   TI
   LI
   LO
   TS
CP0308482
(2S)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]azetidine-2-carboxamide
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C23H26F3N7O
 1
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0369808
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[5-fluoro-4-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]piperidine-3-carboxamide
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C25H32FN7O
 1
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
CP0116344
(3R)-N-[2-(6-cyanopyridin-3-yl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
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C24H29F3N8O
 1
1
EC50 = 6 nM
   TI
   LI
   LO
   TS
CP0116345
(2S)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]pyrrolidine-2-carboxamide
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C24H28F3N7O
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0488526
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(5-fluoro-4-methylpyrimidin-2-yl)piperidine-3-carboxamide
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C19H22ClFN4O
 1
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
CP0414420
4-[1-[6-[(2S)-2-[2-(4-cyanophenyl)ethylcarbamoyl]azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl]-2-methoxybenzoic acid
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C31H31F3N6O4
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0414406
1-[6-[(3R)-3-[2-(4-cyanophenyl)ethylcarbamoyl]piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]-4-methylpiperidine-4-carboxylic acid
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C27H31F3N6O3
 1
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
CP0434558
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-(5-fluoro-4-methylpyrimidin-2-yl)piperidine-3-carboxamide
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C20H22FN5O
 1
1
EC50 = 13 nM
   TI
   LI
   LO
   TS
CP0369809
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
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C24H28F3N7O
 1
1
EC50 = 14 nM
   TI
   LI
   LO
   TS
CP0411576
2-[4-[1-[6-[(3R)-3-[2-(4-cyanophenyl)ethylcarbamoyl]piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl]oxyphenyl]acetic acid
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C33H35F3N6O4
 1
1
EC50 = 14 nM
   TI
   LI
   LO
   TS
CP0116346
CHEMBL3234871
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C31H30F3N5O3
 1
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
CP0480952
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxamide
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C20H20F3N5O
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0382440
4-[1-[6-[(2S)-2-[2-(4-cyanophenyl)ethylcarbamoyl]azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl]oxybenzoic acid
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C30H29F3N6O4
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0157851
(2S)-N-[2-(6-cyanopyridin-3-yl)ethyl]-1-[6-(4-ethylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]azetidine-2-carboxamide
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C23H27F3N8O
 1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CP0415778
(2S)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-2-carboxamide
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C25H30F3N7O
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0414407
4-[4-[6-[(2S)-2-[2-(4-cyanophenyl)ethylcarbamoyl]azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]phenyl]benzoic acid
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C31H24F3N5O3
 1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS
CP0414417
1-[6-[(3R)-3-[2-(4-cyanophenyl)ethylcarbamoyl]piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxylic acid
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C26H29F3N6O3
 1
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
CP0414428
2-[4-[1-[6-[(2S)-2-[2-(4-cyanophenyl)ethylcarbamoyl]azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl]oxyphenyl]acetic acid
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C31H31F3N6O4
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0411144
(3R)-N-[2-(4-bromophenyl)ethyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide
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C19H23BrN4O
 1
1
EC50 = 33 nM
   TI
   LI
   LO
   TS
CP0364409
(3R)-N-[2-(2-cyanopyrimidin-5-yl)ethyl]-1-[6-(4-ethylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
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C24H30F3N9O
 1
1
EC50 = 38 nM
   TI
   LI
   LO
   TS
CP0414410
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide
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C19H23ClN4O
 1
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
CP0341079
(3R)-N-[2-(6-cyanopyridin-3-yl)ethyl]-1-[6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
   Show/Hide
C23H27F3N8O
 1
1
EC50 = 63 nM
   TI
   LI
   LO
   TS
CP0116343
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[4-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]piperidine-3-carboxamide
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C25H33N7O
 1
1
EC50 = 76 nM
   TI
   LI
   LO
   TS
CP0414424
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(5-fluoropyrimidin-2-yl)piperidine-3-carboxamide
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C18H20ClFN4O
 1
1
EC50 = 95 nM
   TI
   LI
   LO
   TS
CP0382439
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
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C20H20F3N5O
 1
1
EC50 = 140 nM
   TI
   LI
   LO
   TS
CP0414415
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(6-methylpyridin-2-yl)piperidine-3-carboxamide
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C20H24ClN3O
 1
1
EC50 = 220 nM
   TI
   LI
   LO
   TS
CP0121521
(2R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]pyrrolidine-2-carboxamide
   Show/Hide
C24H28F3N7O
 1
1
EC50 = 274 nM
   TI
   LI
   LO
   TS
CP0489977
(3R)-N-[2-(4-fluorophenyl)ethyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide
   Show/Hide
C19H23FN4O
 1
1
EC50 = 320 nM
   TI
   LI
   LO
   TS
CP0414408
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-pyrimidin-2-ylpiperidine-3-carboxamide
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C18H21ClN4O
 1
1
EC50 = 350 nM
   TI
   LI
   LO
   TS
CP0121518
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]piperidine-3-carboxamide
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C25H33N7O
 1
1
EC50 = 440 nM
   TI
   LI
   LO
   TS
CP0416044
N-[2-(4-chlorophenyl)ethyl]-1-pyrimidin-2-ylpiperidine-3-carboxamide
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C18H21ClN4O
 1
1
EC50 = 880 nM
   TI
   LI
   LO
   TS
CP0382438
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(4-methylpyridin-2-yl)piperidine-3-carboxamide
   Show/Hide
C20H24ClN3O
 1
1
EC50 = 930 nM
   TI
   LI
   LO
   TS
CP0535797
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-pyridin-2-ylpiperidine-3-carboxamide
   Show/Hide
C19H22ClN3O
 1
1
EC50 = 930 nM
   TI
   LI
   LO
   TS
CP0434559
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(2-methylpyrimidin-4-yl)piperidine-3-carboxamide
   Show/Hide
C19H23ClN4O
 1
1
EC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0434557
(3R)-N-[2-(4-methylphenyl)ethyl]-1-pyrimidin-2-ylpiperidine-3-carboxamide
   Show/Hide
C19H24N4O
 1
1
EC50 = 4300 nM
   TI
   LI
   LO
   TS
CP0414412
(3R)-1-(4-methylpyrimidin-2-yl)-N-(2-phenylethyl)piperidine-3-carboxamide
   Show/Hide
C19H24N4O
 1
1
EC50 = 5800 nM
   TI
   LI
   LO
   TS
CP0382437
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-pyrimidin-4-ylpiperidine-3-carboxamide
   Show/Hide
C18H21ClN4O
 1
1
EC50 = 13700 nM
   TI
   LI
   LO
   TS
CP0414430
(3S)-N-[2-(4-chlorophenyl)ethyl]-1-pyrimidin-2-ylpiperidine-3-carboxamide
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C18H21ClN4O
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0157489
Lmb763
   Show/Hide
C27H22ClN3O4
 1
1
EC50 > 80000 nM
   TI
   LI
   LO
   TS
CP0341080
(2R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]azetidine-2-carboxamide
   Show/Hide
C23H26F3N7O
 1
1
EC50 > 8000 nM
   TI
   LI
   LO
   TS