Compound ID |
Compound Name |
Compound Formula |
CP0121520
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-[4-(oxetan-3-yl)piperazin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
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|
C27H32F3N7O2
|
1
|
1 |
EC50 = 1 nM
|
|
|
CP0157850
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[4-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxamide
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|
C25H30F3N7O
|
1
|
1 |
EC50 = 2 nM
|
|
|
CP0121522
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
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|
C25H30F3N7O
|
1
|
1 |
EC50 = 3 nM
|
|
|
CP0308482
|
(2S)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]azetidine-2-carboxamide
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|
C23H26F3N7O
|
1
|
1 |
EC50 = 4 nM
|
|
|
CP0369808
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[5-fluoro-4-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]piperidine-3-carboxamide
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|
C25H32FN7O
|
1
|
1 |
EC50 = 4 nM
|
|
|
CP0116344
|
(3R)-N-[2-(6-cyanopyridin-3-yl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C24H29F3N8O
|
1
|
1 |
EC50 = 6 nM
|
|
|
CP0116345
|
(2S)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]pyrrolidine-2-carboxamide
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|
C24H28F3N7O
|
1
|
1 |
EC50 = 8 nM
|
|
|
CP0488526
|
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(5-fluoro-4-methylpyrimidin-2-yl)piperidine-3-carboxamide
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|
C19H22ClFN4O
|
1
|
1 |
EC50 = 8 nM
|
|
|
CP0414420
|
4-[1-[6-[(2S)-2-[2-(4-cyanophenyl)ethylcarbamoyl]azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl]-2-methoxybenzoic acid
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|
C31H31F3N6O4
|
1
|
1 |
EC50 = 11 nM
|
|
|
CP0414406
|
1-[6-[(3R)-3-[2-(4-cyanophenyl)ethylcarbamoyl]piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]-4-methylpiperidine-4-carboxylic acid
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|
C27H31F3N6O3
|
1
|
1 |
EC50 = 12 nM
|
|
|
CP0434558
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-(5-fluoro-4-methylpyrimidin-2-yl)piperidine-3-carboxamide
Show/Hide
|
C20H22FN5O
|
1
|
1 |
EC50 = 13 nM
|
|
|
CP0369809
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C24H28F3N7O
|
1
|
1 |
EC50 = 14 nM
|
|
|
CP0411576
|
2-[4-[1-[6-[(3R)-3-[2-(4-cyanophenyl)ethylcarbamoyl]piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl]oxyphenyl]acetic acid
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|
C33H35F3N6O4
|
1
|
1 |
EC50 = 14 nM
|
|
|
CP0116346
|
CHEMBL3234871
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|
C31H30F3N5O3
|
1
|
1 |
EC50 = 15 nM
|
|
|
CP0480952
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxamide
Show/Hide
|
C20H20F3N5O
|
1
|
1 |
EC50 = 17 nM
|
|
|
CP0382440
|
4-[1-[6-[(2S)-2-[2-(4-cyanophenyl)ethylcarbamoyl]azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl]oxybenzoic acid
Show/Hide
|
C30H29F3N6O4
|
1
|
1 |
EC50 = 18 nM
|
|
|
CP0157851
|
(2S)-N-[2-(6-cyanopyridin-3-yl)ethyl]-1-[6-(4-ethylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]azetidine-2-carboxamide
Show/Hide
|
C23H27F3N8O
|
1
|
1 |
EC50 = 19 nM
|
|
|
CP0415778
|
(2S)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-2-carboxamide
Show/Hide
|
C25H30F3N7O
|
1
|
1 |
EC50 = 20 nM
|
|
|
CP0414407
|
4-[4-[6-[(2S)-2-[2-(4-cyanophenyl)ethylcarbamoyl]azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]phenyl]benzoic acid
Show/Hide
|
C31H24F3N5O3
|
1
|
1 |
EC50 = 25 nM
|
|
|
CP0414417
|
1-[6-[(3R)-3-[2-(4-cyanophenyl)ethylcarbamoyl]piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxylic acid
Show/Hide
|
C26H29F3N6O3
|
1
|
1 |
EC50 = 26 nM
|
|
|
CP0414428
|
2-[4-[1-[6-[(2S)-2-[2-(4-cyanophenyl)ethylcarbamoyl]azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl]oxyphenyl]acetic acid
Show/Hide
|
C31H31F3N6O4
|
1
|
1 |
EC50 = 30 nM
|
|
|
CP0411144
|
(3R)-N-[2-(4-bromophenyl)ethyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide
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|
C19H23BrN4O
|
1
|
1 |
EC50 = 33 nM
|
|
|
CP0364409
|
(3R)-N-[2-(2-cyanopyrimidin-5-yl)ethyl]-1-[6-(4-ethylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C24H30F3N9O
|
1
|
1 |
EC50 = 38 nM
|
|
|
CP0414410
|
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide
Show/Hide
|
C19H23ClN4O
|
1
|
1 |
EC50 = 60 nM
|
|
|
CP0341079
|
(3R)-N-[2-(6-cyanopyridin-3-yl)ethyl]-1-[6-piperazin-1-yl-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C23H27F3N8O
|
1
|
1 |
EC50 = 63 nM
|
|
|
CP0116343
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[4-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]piperidine-3-carboxamide
Show/Hide
|
C25H33N7O
|
1
|
1 |
EC50 = 76 nM
|
|
|
CP0414424
|
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(5-fluoropyrimidin-2-yl)piperidine-3-carboxamide
Show/Hide
|
C18H20ClFN4O
|
1
|
1 |
EC50 = 95 nM
|
|
|
CP0382439
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C20H20F3N5O
|
1
|
1 |
EC50 = 140 nM
|
|
|
CP0414415
|
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(6-methylpyridin-2-yl)piperidine-3-carboxamide
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|
C20H24ClN3O
|
1
|
1 |
EC50 = 220 nM
|
|
|
CP0121521
|
(2R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]pyrrolidine-2-carboxamide
Show/Hide
|
C24H28F3N7O
|
1
|
1 |
EC50 = 274 nM
|
|
|
CP0489977
|
(3R)-N-[2-(4-fluorophenyl)ethyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide
Show/Hide
|
C19H23FN4O
|
1
|
1 |
EC50 = 320 nM
|
|
|
CP0414408
|
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-pyrimidin-2-ylpiperidine-3-carboxamide
Show/Hide
|
C18H21ClN4O
|
1
|
1 |
EC50 = 350 nM
|
|
|
CP0121518
|
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]piperidine-3-carboxamide
Show/Hide
|
C25H33N7O
|
1
|
1 |
EC50 = 440 nM
|
|
|
CP0416044
|
N-[2-(4-chlorophenyl)ethyl]-1-pyrimidin-2-ylpiperidine-3-carboxamide
Show/Hide
|
C18H21ClN4O
|
1
|
1 |
EC50 = 880 nM
|
|
|
CP0382438
|
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(4-methylpyridin-2-yl)piperidine-3-carboxamide
Show/Hide
|
C20H24ClN3O
|
1
|
1 |
EC50 = 930 nM
|
|
|
CP0535797
|
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-pyridin-2-ylpiperidine-3-carboxamide
Show/Hide
|
C19H22ClN3O
|
1
|
1 |
EC50 = 930 nM
|
|
|
CP0434559
|
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-(2-methylpyrimidin-4-yl)piperidine-3-carboxamide
Show/Hide
|
C19H23ClN4O
|
1
|
1 |
EC50 = 2100 nM
|
|
|
CP0434557
|
(3R)-N-[2-(4-methylphenyl)ethyl]-1-pyrimidin-2-ylpiperidine-3-carboxamide
Show/Hide
|
C19H24N4O
|
1
|
1 |
EC50 = 4300 nM
|
|
|
CP0414412
|
(3R)-1-(4-methylpyrimidin-2-yl)-N-(2-phenylethyl)piperidine-3-carboxamide
Show/Hide
|
C19H24N4O
|
1
|
1 |
EC50 = 5800 nM
|
|
|
CP0382437
|
(3R)-N-[2-(4-chlorophenyl)ethyl]-1-pyrimidin-4-ylpiperidine-3-carboxamide
Show/Hide
|
C18H21ClN4O
|
1
|
1 |
EC50 = 13700 nM
|
|
|
CP0414430
|
(3S)-N-[2-(4-chlorophenyl)ethyl]-1-pyrimidin-2-ylpiperidine-3-carboxamide
Show/Hide
|
C18H21ClN4O
|
1
|
1 |
EC50 > 80000 nM
|
|
|
CP0157489
|
Lmb763
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|
C27H22ClN3O4
|
1
|
1 |
EC50 > 80000 nM
|
|
|
CP0341080
|
(2R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]azetidine-2-carboxamide
Show/Hide
|
C23H26F3N7O
|
1
|
1 |
EC50 > 8000 nM
|
|
|