| Compound ID |
Compound Name |
Compound Formula |
|
CP0400458
|
3-nitro-2-[4-(3-phenylprop-2-ynylidene)piperidin-1-yl]pyridine
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|
C19H17N3O2
|
2
|
| 1 |
IC50 = 39.3 nM
|
|
|
| 2 |
Ki = 4.8 nM
|
|
|
|
CP0410820
|
3-nitro-2-[4-(3-pyridin-2-ylprop-2-ynylidene)piperidin-1-yl]pyridine
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|
C18H16N4O2
|
2
|
| 1 |
IC50 = 206.7 nM
|
|
|
| 2 |
Ki = 39.1 nM
|
|
|
|
CP0410806
|
1-[4-(3-nitropyridin-2-yl)piperazin-1-yl]-3-phenylprop-2-yn-1-one
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|
C18H16N4O3
|
2
|
| 1 |
IC50 = 271 nM
|
|
|
| 2 |
Ki = 96.8 nM
|
|
|
|
CP0163635
|
2-methyl-6-[3-[1-(3-nitropyridin-2-yl)piperidin-4-ylidene]prop-1-ynyl]pyridine
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|
C19H18N4O2
|
2
|
| 1 |
IC50 = 447.5 nM
|
|
|
| 2 |
Ki = 184.2 nM
|
|
|
|
CP0410803
|
2-[4-[3-(3-methylphenyl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine
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|
C20H19N3O2
|
2
|
| 1 |
IC50 = 543.4 nM
|
|
|
| 2 |
Ki = 18.6 nM
|
|
|
|
CP0448934
|
2-methyl-6-[3-[1-(2-nitrophenyl)piperidin-4-ylidene]prop-1-ynyl]pyridine
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|
C20H19N3O2
|
2
|
| 1 |
IC50 = 550.7 nM
|
|
|
| 2 |
Ki = 70.7 nM
|
|
|
|
CP0381788
|
2-[4-[3-(3-chlorophenyl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine
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|
C19H16ClN3O2
|
2
|
| 1 |
IC50 = 1337 nM
|
|
|
| 2 |
Ki = 18.6 nM
|
|
|
|
CP0545393
|
1-[4-(6-ethenyl-3-nitropyridin-2-yl)piperazin-1-yl]-3-phenylprop-2-yn-1-one
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|
C20H18N4O3
|
1
|
| 1 |
Ki = 54.2 nM
|
|
|
|
CP0410805
|
1-[4-(2-nitrophenyl)piperazin-1-yl]-3-phenylprop-2-yn-1-one
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|
C19H17N3O3
|
1
|
| 1 |
Ki = 69.3 nM
|
|
|
|
CP0453226
|
6-[3-[1-(6-methyl-3-nitropyridin-2-yl)piperidin-4-ylidene]prop-1-ynyl]pyridine-3-carbonitrile
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|
C20H17N5O2
|
1
|
| 1 |
Ki = 189.6 nM
|
|
|
|
CP0205249
|
2-phenylethyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
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|
C23H24N2O2
|
1
|
| 1 |
Ki = 413 nM
|
|
|
|
CP0534566
|
2-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-5-phenylpyridine-3-carbonitrile
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|
C26H22N4
|
1
|
| 1 |
Ki = 443.1 nM
|
|
|
|
CP0098719
|
2-methyl-4-(pyridin-3-ylethynyl)thiazole
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|
C11H8N2S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0191235
|
2-Methyl-6-(phenylethynyl)pyridine
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|
C14H11N
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0374317
|
2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyridine
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|
C16H11N3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0410807
|
5-methyl-2-[(3E)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine
Show/Hide
|
C20H20N4O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0456043
|
1-(3-nitropyridin-2-yl)-4-(3-phenylprop-2-ynyl)piperazine
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|
C18H18N4O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0488095
|
6-methyl-2-[(3Z)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-3-nitropyridine
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|
C20H20N4O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0498981
|
3-chloro-5-[3-[1-(3-nitropyridin-2-yl)piperidin-4-ylidene]prop-1-ynyl]benzonitrile
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|
C20H15ClN4O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0060761
|
1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]butan-1-one
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|
C18H22N2O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0060762
|
ethyl 4-[3-(3-chlorophenyl)prop-2-ynylidene]piperidine-1-carboxylate
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|
C17H18ClNO2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0060764
|
ethyl 4-[3-(3-cyanophenyl)prop-2-ynylidene]piperidine-1-carboxylate
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|
C18H18N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0063927
|
(3-methylphenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
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|
C22H22N2O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0063934
|
4-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]sulfonylbenzonitrile
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|
C21H19N3O2S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0096630
|
ethyl 4-(3-pyridin-2-ylprop-2-ynylidene)piperidine-1-carboxylate
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|
C16H18N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0096631
|
methyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C16H18N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0096632
|
2-[3-[1-(4-methoxyphenyl)sulfonylpiperidin-4-ylidene]prop-1-ynyl]-6-methylpyridine
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|
C21H22N2O3S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0096634
|
ethyl 4-[3-(3-methylphenyl)prop-2-ynylidene]piperidine-1-carboxylate
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|
C18H21NO2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0096665
|
[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-phenylmethanone
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|
C21H20N2O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0096669
|
2-[3-(1-ethylsulfonylpiperidin-4-ylidene)prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C16H20N2O2S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0098717
|
ethyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C17H20N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0098720
|
2-methyl-6-[3-[1-(4-methylphenyl)sulfonylpiperidin-4-ylidene]prop-1-ynyl]pyridine
Show/Hide
|
C21H22N2O2S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0098722
|
N-ethyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-propan-2-ylpiperidine-1-carboxamide
Show/Hide
|
C20H27N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0098731
|
ethyl 4-[3-(3-fluorophenyl)prop-2-ynylidene]piperidine-1-carboxylate
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|
C17H18FNO2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0098733
|
ethyl 6-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-2-azaspiro[3.3]heptane-2-carboxylate
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|
C18H20N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0168546
|
(3-chlorophenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C21H19ClN2O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0168548
|
benzyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
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|
C22H22N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0168550
|
(3E)-N-methyl-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-propan-2-ylpyrrolidine-1-carboxamide
Show/Hide
|
C18H23N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0168551
|
2-[3-[1-(3-bromophenyl)sulfonylpiperidin-4-ylidene]prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C20H19BrN2O2S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0168566
|
ethyl (3E)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]pyrrolidine-1-carboxylate
Show/Hide
|
C16H18N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0205245
|
N-butyl-N-methyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxamide
Show/Hide
|
C20H27N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0205248
|
(3-chlorophenyl)-[4-[3-(6-chloropyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C20H16Cl2N2O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0234525
|
N-methyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-(1-phenylethyl)piperidine-1-carboxamide
Show/Hide
|
C24H27N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0234531
|
(3-methoxyphenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C22H22N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0330107
|
(2-methoxyphenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C22H22N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0330115
|
(3E)-N-ethyl-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-propan-2-ylpyrrolidine-1-carboxamide
Show/Hide
|
C19H25N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0384226
|
N-tert-butyl-N-methyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxamide
Show/Hide
|
C20H27N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0402213
|
tert-butyl 4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate
Show/Hide
|
C19H24N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0412986
|
2-[3-[1-(cyclohexylmethylsulfonyl)piperidin-4-ylidene]prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C21H28N2O2S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0421536
|
(3-fluorophenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C21H19FN2O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0437675
|
ethyl (3Z)-3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]pyrrolidine-1-carboxylate
Show/Hide
|
C16H18N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0440308
|
3,3-dimethyl-1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]butan-1-one
Show/Hide
|
C20H26N2O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0459736
|
N-butyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxamide
Show/Hide
|
C19H25N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0459744
|
N-tert-butyl-4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxamide
Show/Hide
|
C19H25N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0474156
|
2-[3-(1-benzylsulfonylpiperidin-4-ylidene)prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C21H22N2O2S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0474157
|
2-(3,5-difluorophenyl)-1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]ethanone
Show/Hide
|
C22H20F2N2O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0474170
|
2-methoxy-1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]ethanone
Show/Hide
|
C17H20N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0474171
|
ethyl 3-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]azetidine-1-carboxylate
Show/Hide
|
C15H16N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0524574
|
2-[3-[1-(benzenesulfonyl)piperidin-4-ylidene]prop-1-ynyl]-6-methylpyridine
Show/Hide
|
C20H20N2O2S
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0558164
|
(4-methoxyphenyl)-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]methanone
Show/Hide
|
C22H22N2O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0563387
|
1-[4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl]-2-phenylethanone
Show/Hide
|
C22H22N2O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0567454
|
4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]-N-(1-phenylethyl)piperidine-1-carboxamide
Show/Hide
|
C23H25N3O
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
