Brief Information of the Cell Line and Protein
Cell Line ID: CL000040 , THP-1
 Cell Line Info 
Synonyms
THP1
THP 1
THPI
THP-1(ATCC)
THP-1-O
O-THP-1
Tohoku Hospital Pediatrics-1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0006
Protein ID: PT02347 , Tumor necrosis factor
 Protein Info 
Gene Name TNF
Organism Homo sapiens, Human
Protein Classification Secreted protein
Uniprot ID P01375
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000040
 Cell Line Info 
 Protein ID: PT02347
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0043074
 Compound Info 
1-(5-tert-Butyl-2-phenyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea
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C30H35N5O3
  1
1
EC50 = 9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0366150
 Compound Info 
1-[2-(4-Aminophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]urea
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C30H36N6O3
  1
1
EC50 = 9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0124432
 Compound Info 
1-[2-(3-Aminophenyl)-5-tert-butyl-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]urea
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C30H36N6O3
  1
1
EC50 = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0062540
 Compound Info 
1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{4-[2-((2S,-6S)-2,6-dimethylmorpholin-4-yl)-ethoxy]naphthalen-1-yl}urea
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C33H41N5O3
  1
1
EC50 = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0018897
 Compound Info 
1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
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C31H37N5O3
  1
1
EC50 = 18 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0042961
 Compound Info 
1-[5-tert-Butyl-2-(6-methyl-pyridin-3-yl)-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea
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C30H36N6O3
  1
1
EC50 = 19 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0066980
 Compound Info 
1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-pyridin-4-yl-ethoxy)-naphthalen-1-yl]-urea
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C32H33N5O2
  1
1
EC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0048246
 Compound Info 
1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-imidazol-1-yl-ethoxy)-naphthalen-1-yl]-urea
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C30H32N6O2
  1
1
EC50 = 36 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0061523
 Compound Info 
1-[5-tert-Butyl-2-(6-methoxypyridin-3-yl)-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea
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C30H36N6O4
  1
1
EC50 = 42 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0047539
 Compound Info 
1-[5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl]-3-[4-(2-(1-oxothiomorpholin-4-yl)ethoxy)naphthalen-1-yl]-urea
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C31H37N5O3S
  1
1
EC50 = 50 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS