Brief Information of the Cell Line and Protein
Cell Line ID: CL000142 , ZR-75-1
Synonyms
Zr-75-1
ZR751
ZR75-1
ZR75.1
ZR75_1
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0588
Protein ID: PT02178 , LIM domain kinase 1
Gene Name LIMK1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P53667
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000142  Protein ID: PT02178
 
Compound ID Compound Name Compound Formula
CP0061772
1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea
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C23H23N7O2S
 1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0116716
N-[5-[2-(2,6-dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methylpropanamide
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C17H14Cl2F2N4OS
 1
1
IC50 = 220 nM
   TI
   LI
   LO
   TS
CP0384862
5-[3-(2-chlorophenyl)pyridin-4-yl]-N-phenyl-1,3-thiazol-2-amine
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C20H14ClN3S
 1
1
IC50 = 600 nM
   TI
   LI
   LO
   TS
CP0384865
N-[5-[3-(2-chlorophenyl)pyridin-4-yl]-1,3-thiazol-2-yl]-2-methylpropanamide
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C18H16ClN3OS
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0654396
3-(4-Amino-benzo[4,5]thieno[3,2-d]pyrimidin-7-yl)-N-(2-morpholin-4-yl-2-oxo-ethyl)-benzamide
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C23H21N5O3S
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0380087
N-[5-[3-(2-chlorophenyl)pyridin-4-yl]-1,3-thiazol-2-yl]acetamide
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C16H12ClN3OS
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0487240
5-[3-(2-chlorophenyl)pyridin-4-yl]-N-(2-methylpropyl)-1,3-thiazol-2-amine
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C18H18ClN3S
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0697136
4-Methyl-piperazine-1-carboxylic acid [3-(4-amino-benzo[4,5]thieno[3,2-d]pyrimidin-7-yl)-phenyl]-amide
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C22H22N6OS
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0054626
N-[5-[3-[4-methoxy-2-(trifluoromethyl)phenyl]pyridin-4-yl]-1,3-thiazol-2-yl]-2-methylpropanamide
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C20H18F3N3O2S
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0431874
5-[3-(2-chlorophenyl)pyridin-4-yl]-N-[(1R)-1-phenylethyl]-1,3-thiazol-2-amine
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C22H18ClN3S
 1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0431875
N-propyl-5-[3-[2-(trifluoromethyl)phenyl]pyridin-4-yl]-1,3-thiazol-2-amine
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C18H16F3N3S
 1
1
IC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0654400
Pyrrolidine-1-carboxylic acid [3-(4-amino-benzo[4,5]thieno[3,2-d]pyrimidin-7-yl)-phenyl]-amid
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C21H19N5OS
 1
1
IC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0388131
5-[3-[4-methoxy-2-(trifluoromethyl)phenyl]pyridin-4-yl]-N-propyl-1,3-thiazol-2-amine
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C19H18F3N3OS
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0394994
5-[3-(2-chlorophenyl)pyridin-4-yl]-N-propyl-1,3-thiazol-2-amine
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C17H16ClN3S
 1
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0654395
3-(4-Amino-benzo[4,5]thieno[3,2-d]pyrimidin-7-yl)-N-(2-pyridin-3-yl-ethyl)-benzamide
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C24H19N5OS
 1
1
IC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0213232
4-[[5-[3-(2-chlorophenyl)pyridin-4-yl]-1,3-thiazol-2-yl]amino]phenol
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C20H14ClN3OS
 1
1
IC50 = 6600 nM
   TI
   LI
   LO
   TS
CP0417266
5-[3-(2-chlorophenyl)pyridin-4-yl]-N-[(1S)-1-phenylethyl]-1,3-thiazol-2-amine
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C22H18ClN3S
 1
1
IC50 = 9200 nM
   TI
   LI
   LO
   TS
CP0458946
5-[3-(2-methylphenyl)pyridin-4-yl]-N-propyl-1,3-thiazol-2-amine
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C18H19N3S
 1
1
IC50 = 11500 nM
   TI
   LI
   LO
   TS
CP0431873
5-[3-(2-chlorophenyl)pyridin-4-yl]-N-ethyl-1,3-thiazol-2-amine
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C16H14ClN3S
 1
1
IC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0663818
1-[3-(4-Amino-benzo[4,5]thieno[3,2-d]pyrimidin-7-yl)-phenyl]-3-ethyl-urea
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C19H17N5OS
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0762159
7-[3-(2H-Tetrazol-5-yl)-phenyl]-benzo[4,5]thieno[3,2-d]pyrimidin-4-ylamine
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C17H11N7S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0843120
3-(4-Amino-benzo[4,5]thieno[3,2-d]pyrimidin-7-yl)-benzamide
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C17H12N4OS
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0406085
5-[3-(2-chlorophenyl)pyridin-4-yl]-1,3-thiazol-2-amine
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C14H10ClN3S
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS