Brief Information of the Compound and Protein
Compound Name
1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea
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PubChem ID
CID: 46192505
SID: 96046168
Canonical SMILES
CCNC(=O)Nc1ncc(s1)-c1cc(nc(n1)-c1cnccn1)-c1c(C)cc(OC)cc1C
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Compound Formula C23H23N7O2S
Compound Structure
Protein Name
LIM domain kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase LISK family
>
TKL protein kinase LIMK subfamily
Uniprot ID
P53667
Gene Name
LIMK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 354.81 nM
   TI
   LI
   LO
   TS
CL000142 ZR-75-1 Homo sapiens (Human)  1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 54 nM
2 IC50 = 56.23 nM
3 IC50 = 58 nM
4 IC50 = 2290.87 nM