Compound ID |
Compound Name |
Compound Formula |
CP0573081
|
(8S)-N-methyl-N-[[2-methyl-6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H34N6
|
1
|
1 |
IC50 = 8.3 nM
|
|
|
CP0577466
|
(8S)-N-[[6-[(3R)-3,4-dimethylpiperazin-1-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H32N6
|
1
|
1 |
IC50 = 8.3 nM
|
|
|
CP0531332
|
(8S)-N-methyl-N-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 8.8 nM
|
|
|
CP0544466
|
(8S)-N-[[6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H32N6
|
1
|
1 |
IC50 = 10 nM
|
|
|
CP0546087
|
N-[[5-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H29FN6
|
1
|
1 |
IC50 = 12 nM
|
|
|
CP0579039
|
N-methyl-N-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 12 nM
|
|
|
CP0533965
|
(8S)-N-[[6-[(3S)-3,4-dimethylpiperazin-1-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H32N6
|
1
|
1 |
IC50 = 14 nM
|
|
|
CP0533966
|
(8S)-N-[[6-[(2S)-2,4-dimethylpiperazin-1-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H32N6
|
1
|
1 |
IC50 = 14 nM
|
|
|
CP0533968
|
N-ethyl-N-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H32N6
|
1
|
1 |
IC50 = 17 nM
|
|
|
CP0542860
|
N'-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
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|
C23H35N7
|
1
|
1 |
IC50 = 18 nM
|
|
|
CP0549009
|
tert-butyl N-[4-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl-(5,6,7,8-tetrahydroquinolin-8-yl)amino]butyl]carbamate
Show/Hide
|
C28H43N7O2
|
1
|
1 |
IC50 = 18 nM
|
|
|
CP0578742
|
(8S)-N-[[6-[(8aS)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H32N6
|
1
|
1 |
IC50 = 18 nM
|
|
|
CP0553119
|
(8S)-N-[[6-[(2R)-2,4-dimethylpiperazin-1-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H32N6
|
1
|
1 |
IC50 = 21 nM
|
|
|
CP0553121
|
N-[[2-cyclopropyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H32N6
|
1
|
1 |
IC50 = 23 nM
|
|
|
CP0560456
|
N-[[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C20H29N7
|
1
|
1 |
IC50 = 23 nM
|
|
|
CP0546106
|
N-[[2-methoxy-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
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|
C21H30N6O
|
1
|
1 |
IC50 = 25 nM
|
|
|
CP0576521
|
N-[[2-ethyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H32N6
|
1
|
1 |
IC50 = 25 nM
|
|
|
CP0465609
|
(8S)-N-[[6-[(8aR)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H32N6
|
1
|
1 |
IC50 = 30 nM
|
|
|
CP0557204
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[methyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]pyrimidine-5-carbonitrile
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|
C22H29N7
|
1
|
1 |
IC50 = 33 nM
|
|
|
CP0553118
|
(8S)-N-methyl-N-[[2-methyl-6-(3-morpholin-4-ylpropylamino)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H34N6O
|
1
|
1 |
IC50 = 36 nM
|
|
|
CP0579038
|
N-(cyclopropylmethyl)-N-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H34N6
|
1
|
1 |
IC50 = 51 nM
|
|
|
CP0416469
|
N-methyl-N-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine;hydrochloride
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|
C20H29ClN6
|
1
|
1 |
IC50 = 54 nM
|
|
|
CP0531335
|
N-methyl-N-[[2-(methylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H31N7
|
1
|
1 |
IC50 = 58 nM
|
|
|
CP0533964
|
(8S)-N-methyl-N-[[2-methyl-6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H32N6O
|
1
|
1 |
IC50 = 66 nM
|
|
|
CP0573082
|
(8S)-N-[[6-(4-cyclopropylpiperazin-1-yl)-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H32N6
|
1
|
1 |
IC50 = 70 nM
|
|
|
CP0570378
|
N-[[2-ethoxy-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H32N6O
|
1
|
1 |
IC50 = 78 nM
|
|
|
CP0549751
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-(3-methylpyridin-2-yl)pyrrolidin-1-yl]methyl]pyrimidine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 79 nM
|
|
|
CP0429796
|
(8S)-N-methyl-N-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 = 88 nM
|
|
|
CP0578741
|
(8S)-N-methyl-N-[[2-methyl-6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H39N7
|
1
|
1 |
IC50 = 96 nM
|
|
|
CP0576520
|
(8S)-N-methyl-N-[[2-methyl-6-(4-morpholin-4-ylpiperidin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C25H36N6O
|
1
|
1 |
IC50 = 101 nM
|
|
|
CP0531333
|
N-[[2-(ethylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H33N7
|
1
|
1 |
IC50 = 105 nM
|
|
|
CP0560458
|
(8S)-N-methyl-N-[[2-methyl-6-[4-(oxetan-3-yl)piperazin-1-yl]pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H32N6O
|
1
|
1 |
IC50 = 130 nM
|
|
|
CP0464395
|
3-N,3-N-dimethyl-1-N-(pyrimidin-4-ylmethyl)-1-N-(5,6,7,8-tetrahydroquinolin-8-yl)pyrrolidine-1,3-diamine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 = 150 nM
|
|
|
CP0553120
|
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-propan-2-yloxypyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H34N6O
|
1
|
1 |
IC50 = 151 nM
|
|
|
CP0557346
|
N-(4-methyl-1,4-diazepan-1-yl)-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 = 170 nM
|
|
|
CP0575705
|
N-methyl-N-[[4-(4-methylpiperazin-1-yl)pyrimidin-2-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 = 180 nM
|
|
|
CP0566837
|
N-methyl-N-[[4-(4-methylpiperazin-1-yl)pyridin-2-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H29N5
|
1
|
1 |
IC50 = 200 nM
|
|
|
CP0416471
|
N-(4-propan-2-ylpiperazin-1-yl)-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 210 nM
|
|
|
CP0563467
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-(4-methylpyridin-2-yl)pyrrolidin-1-yl]methyl]pyrimidine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 216 nM
|
|
|
CP0565933
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-pyridin-2-ylpyrrolidin-1-yl]methyl]pyrimidine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 = 220 nM
|
|
|
CP0544467
|
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-propan-2-ylpyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H34N6
|
1
|
1 |
IC50 = 256 nM
|
|
|
CP0425223
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-(5-methylpyridin-2-yl)pyrrolidin-1-yl]methyl]pyrimidine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 278 nM
|
|
|
CP0145769
|
1,1''-{1,4-phenylenebis(methylene)}-bis{1,4,8,11-tetraaza-cyclotetradecane}
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|
C28H54N8
|
3
|
1 |
IC50 = 290 nM
|
|
|
2 |
IC50 = 303 nM
|
|
|
3 |
IC50 = 561 nM
|
|
|
CP0549028
|
2-[4-[pyrimidin-4-ylmethyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]piperazin-1-yl]ethanol
Show/Hide
|
C20H28N6O
|
1
|
1 |
IC50 = 290 nM
|
|
|
CP0573083
|
(8S)-N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H27F3N6
|
1
|
1 |
IC50 = 293 nM
|
|
|
CP0558042
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[(2-pyridin-2-ylpyrrolidin-1-yl)methyl]pyrimidine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 = 319 nM
|
|
|
CP0383895
|
N-(4-ethylpiperazin-1-yl)-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 = 320 nM
|
|
|
CP0534672
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[(2-pyridin-2-ylpiperidin-1-yl)methyl]pyrimidine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 620 nM
|
|
|
CP0549011
|
4-N,4-N-dimethyl-1-N-(pyrimidin-4-ylmethyl)-1-N-(5,6,7,8-tetrahydroquinolin-8-yl)piperidine-1,4-diamine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 630 nM
|
|
|
CP0416472
|
2-(2-morpholin-4-ylethyl)-1-(pyrimidin-4-ylmethyl)-1-(5,6,7,8-tetrahydroquinolin-8-yl)hydrazine
Show/Hide
|
C20H28N6O
|
1
|
1 |
IC50 = 640 nM
|
|
|
CP0531334
|
2-[methyl-[4-(4-methylpiperazin-1-yl)-6-[[methyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]pyrimidin-2-yl]amino]ethanol
Show/Hide
|
C23H35N7O
|
1
|
1 |
IC50 = 792 nM
|
|
|
CP0578740
|
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-(propan-2-ylamino)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C23H35N7
|
1
|
1 |
IC50 = 930 nM
|
|
|
CP0429795
|
N,N-dimethyl-2-[methyl-[pyrimidin-4-ylmethyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]amino]ethanamine
Show/Hide
|
C19H28N6
|
1
|
1 |
IC50 = 1020 nM
|
|
|
CP0549010
|
N-[4-(cyclopropylmethyl)piperazin-1-yl]-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H30N6
|
1
|
1 |
IC50 = 1050 nM
|
|
|
CP0578829
|
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-(1-methylpyrazol-4-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H32N8
|
1
|
1 |
IC50 = 1294 nM
|
|
|
CP0477787
|
(8R)-N-methyl-N-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 = 1300 nM
|
|
|
CP0534673
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[(3-methyl-2-pyridin-2-ylpyrrolidin-1-yl)methyl]pyrimidine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 1546 nM
|
|
|
CP0425224
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-(6-methylpyridin-2-yl)pyrrolidin-1-yl]methyl]pyrimidine
Show/Hide
|
C21H30N6
|
1
|
1 |
IC50 = 2391 nM
|
|
|
CP0560457
|
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-morpholin-4-ylpyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H35N7O
|
1
|
1 |
IC50 = 2442 nM
|
|
|
CP0564809
|
N-piperazin-1-yl-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C18H24N6
|
1
|
1 |
IC50 = 2600 nM
|
|
|
CP0557203
|
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-phenylpyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C26H32N6
|
1
|
1 |
IC50 = 2891 nM
|
|
|
CP0429793
|
N-methyl-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C15H18N4
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0429794
|
N-[[6-(dimethylamino)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C17H23N5
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0464394
|
N-methyl-N-[[2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0549027
|
N-methyl-N-[[2-(4-methylpiperazin-1-yl)pyridin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H29N5
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0569603
|
tert-butyl 4-[pyrimidin-4-ylmethyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]piperazine-1-carboxylate
Show/Hide
|
C23H32N6O2
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0569825
|
N-methyl-N-[[6-(4-methylpiperazin-1-yl)pyridin-2-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C21H29N5
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0533970
|
N-[[2-(dimethylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C22H33N7
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0544468
|
2-[methyl-[2-methyl-6-[[methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]methyl]pyrimidin-4-yl]amino]ethanol
Show/Hide
|
C19H27N5O
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0570379
|
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-pyrrolidin-1-ylpyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
Show/Hide
|
C24H35N7
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0558015
|
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2R)-2-pyridin-2-ylpyrrolidin-1-yl]methyl]pyrimidine
Show/Hide
|
C20H28N6
|
1
|
1 |
IC50 > 10000 nM
|
|
|