Brief Information of the Cell Line and Protein
Cell Line ID: CL000571 , HPB-ALL
Synonyms
HPB/ALL
HPBALL
FCCH1018
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1820
Protein ID: PT02059 , C-X-C chemokine receptor type 4
Gene Name CXCR4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P61073
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000571  Protein ID: PT02059
 
Compound ID Compound Name Compound Formula
CP0573081
(8S)-N-methyl-N-[[2-methyl-6-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H34N6
 1
1
IC50 = 8.3 nM
   TI
   LI
   LO
   TS
CP0577466
(8S)-N-[[6-[(3R)-3,4-dimethylpiperazin-1-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H32N6
 1
1
IC50 = 8.3 nM
   TI
   LI
   LO
   TS
CP0531332
(8S)-N-methyl-N-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H30N6
 1
1
IC50 = 8.8 nM
   TI
   LI
   LO
   TS
CP0544466
(8S)-N-[[6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H32N6
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0546087
N-[[5-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H29FN6
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0579039
N-methyl-N-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H30N6
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0533965
(8S)-N-[[6-[(3S)-3,4-dimethylpiperazin-1-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H32N6
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0533966
(8S)-N-[[6-[(2S)-2,4-dimethylpiperazin-1-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H32N6
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0533968
N-ethyl-N-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H32N6
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0542860
N'-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
   Show/Hide
C23H35N7
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0549009
tert-butyl N-[4-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl-(5,6,7,8-tetrahydroquinolin-8-yl)amino]butyl]carbamate
   Show/Hide
C28H43N7O2
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0578742
(8S)-N-[[6-[(8aS)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H32N6
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0553119
(8S)-N-[[6-[(2R)-2,4-dimethylpiperazin-1-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H32N6
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0553121
N-[[2-cyclopropyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H32N6
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0560456
N-[[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C20H29N7
 1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CP0546106
N-[[2-methoxy-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H30N6O
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0576521
N-[[2-ethyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H32N6
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0465609
(8S)-N-[[6-[(8aR)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H32N6
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0557204
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[methyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]pyrimidine-5-carbonitrile
   Show/Hide
C22H29N7
 1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CP0553118
(8S)-N-methyl-N-[[2-methyl-6-(3-morpholin-4-ylpropylamino)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H34N6O
 1
1
IC50 = 36 nM
   TI
   LI
   LO
   TS
CP0579038
N-(cyclopropylmethyl)-N-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C24H34N6
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0416469
N-methyl-N-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine;hydrochloride
   Show/Hide
C20H29ClN6
 1
1
IC50 = 54 nM
   TI
   LI
   LO
   TS
CP0531335
N-methyl-N-[[2-(methylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H31N7
 1
1
IC50 = 58 nM
   TI
   LI
   LO
   TS
CP0533964
(8S)-N-methyl-N-[[2-methyl-6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H32N6O
 1
1
IC50 = 66 nM
   TI
   LI
   LO
   TS
CP0573082
(8S)-N-[[6-(4-cyclopropylpiperazin-1-yl)-2-methylpyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H32N6
 1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0570378
N-[[2-ethoxy-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H32N6O
 1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CP0549751
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-(3-methylpyridin-2-yl)pyrrolidin-1-yl]methyl]pyrimidine
   Show/Hide
C21H30N6
 1
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
CP0429796
(8S)-N-methyl-N-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C20H28N6
 1
1
IC50 = 88 nM
   TI
   LI
   LO
   TS
CP0578741
(8S)-N-methyl-N-[[2-methyl-6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C26H39N7
 1
1
IC50 = 96 nM
   TI
   LI
   LO
   TS
CP0576520
(8S)-N-methyl-N-[[2-methyl-6-(4-morpholin-4-ylpiperidin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C25H36N6O
 1
1
IC50 = 101 nM
   TI
   LI
   LO
   TS
CP0531333
N-[[2-(ethylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H33N7
 1
1
IC50 = 105 nM
   TI
   LI
   LO
   TS
CP0560458
(8S)-N-methyl-N-[[2-methyl-6-[4-(oxetan-3-yl)piperazin-1-yl]pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H32N6O
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0464395
3-N,3-N-dimethyl-1-N-(pyrimidin-4-ylmethyl)-1-N-(5,6,7,8-tetrahydroquinolin-8-yl)pyrrolidine-1,3-diamine
   Show/Hide
C20H28N6
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0553120
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-propan-2-yloxypyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H34N6O
 1
1
IC50 = 151 nM
   TI
   LI
   LO
   TS
CP0557346
N-(4-methyl-1,4-diazepan-1-yl)-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C20H28N6
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0575705
N-methyl-N-[[4-(4-methylpiperazin-1-yl)pyrimidin-2-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C20H28N6
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0566837
N-methyl-N-[[4-(4-methylpiperazin-1-yl)pyridin-2-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H29N5
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0416471
N-(4-propan-2-ylpiperazin-1-yl)-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H30N6
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0563467
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-(4-methylpyridin-2-yl)pyrrolidin-1-yl]methyl]pyrimidine
   Show/Hide
C21H30N6
 1
1
IC50 = 216 nM
   TI
   LI
   LO
   TS
CP0565933
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-pyridin-2-ylpyrrolidin-1-yl]methyl]pyrimidine
   Show/Hide
C20H28N6
 1
1
IC50 = 220 nM
   TI
   LI
   LO
   TS
CP0544467
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-propan-2-ylpyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H34N6
 1
1
IC50 = 256 nM
   TI
   LI
   LO
   TS
CP0425223
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-(5-methylpyridin-2-yl)pyrrolidin-1-yl]methyl]pyrimidine
   Show/Hide
C21H30N6
 1
1
IC50 = 278 nM
   TI
   LI
   LO
   TS
CP0145769
1,1''-{1,4-phenylenebis(methylene)}-bis{1,4,8,11-tetraaza-cyclotetradecane}
   Show/Hide
C28H54N8
 3
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
2
IC50 = 303 nM
   TI
   LI
   LO
   TS
3
IC50 = 561 nM
   TI
   LI
   LO
   TS
CP0549028
2-[4-[pyrimidin-4-ylmethyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]piperazin-1-yl]ethanol
   Show/Hide
C20H28N6O
 1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS
CP0573083
(8S)-N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H27F3N6
 1
1
IC50 = 293 nM
   TI
   LI
   LO
   TS
CP0558042
2-methyl-4-(4-methylpiperazin-1-yl)-6-[(2-pyridin-2-ylpyrrolidin-1-yl)methyl]pyrimidine
   Show/Hide
C20H28N6
 1
1
IC50 = 319 nM
   TI
   LI
   LO
   TS
CP0383895
N-(4-ethylpiperazin-1-yl)-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C20H28N6
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0534672
2-methyl-4-(4-methylpiperazin-1-yl)-6-[(2-pyridin-2-ylpiperidin-1-yl)methyl]pyrimidine
   Show/Hide
C21H30N6
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0549011
4-N,4-N-dimethyl-1-N-(pyrimidin-4-ylmethyl)-1-N-(5,6,7,8-tetrahydroquinolin-8-yl)piperidine-1,4-diamine
   Show/Hide
C21H30N6
 1
1
IC50 = 630 nM
   TI
   LI
   LO
   TS
CP0416472
2-(2-morpholin-4-ylethyl)-1-(pyrimidin-4-ylmethyl)-1-(5,6,7,8-tetrahydroquinolin-8-yl)hydrazine
   Show/Hide
C20H28N6O
 1
1
IC50 = 640 nM
   TI
   LI
   LO
   TS
CP0531334
2-[methyl-[4-(4-methylpiperazin-1-yl)-6-[[methyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]methyl]pyrimidin-2-yl]amino]ethanol
   Show/Hide
C23H35N7O
 1
1
IC50 = 792 nM
   TI
   LI
   LO
   TS
CP0578740
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-(propan-2-ylamino)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C23H35N7
 1
1
IC50 = 930 nM
   TI
   LI
   LO
   TS
CP0429795
N,N-dimethyl-2-[methyl-[pyrimidin-4-ylmethyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]amino]ethanamine
   Show/Hide
C19H28N6
 1
1
IC50 = 1020 nM
   TI
   LI
   LO
   TS
CP0549010
N-[4-(cyclopropylmethyl)piperazin-1-yl]-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H30N6
 1
1
IC50 = 1050 nM
   TI
   LI
   LO
   TS
CP0578829
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-(1-methylpyrazol-4-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C24H32N8
 1
1
IC50 = 1294 nM
   TI
   LI
   LO
   TS
CP0477787
(8R)-N-methyl-N-[[6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C20H28N6
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0534673
2-methyl-4-(4-methylpiperazin-1-yl)-6-[(3-methyl-2-pyridin-2-ylpyrrolidin-1-yl)methyl]pyrimidine
   Show/Hide
C21H30N6
 1
1
IC50 = 1546 nM
   TI
   LI
   LO
   TS
CP0425224
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2S)-2-(6-methylpyridin-2-yl)pyrrolidin-1-yl]methyl]pyrimidine
   Show/Hide
C21H30N6
 1
1
IC50 = 2391 nM
   TI
   LI
   LO
   TS
CP0560457
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-morpholin-4-ylpyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C24H35N7O
 1
1
IC50 = 2442 nM
   TI
   LI
   LO
   TS
CP0564809
N-piperazin-1-yl-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C18H24N6
 1
1
IC50 = 2600 nM
   TI
   LI
   LO
   TS
CP0557203
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-phenylpyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C26H32N6
 1
1
IC50 = 2891 nM
   TI
   LI
   LO
   TS
CP0429793
N-methyl-N-(pyrimidin-4-ylmethyl)-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C15H18N4
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0429794
N-[[6-(dimethylamino)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C17H23N5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0464394
N-methyl-N-[[2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C20H28N6
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0549027
N-methyl-N-[[2-(4-methylpiperazin-1-yl)pyridin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H29N5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0569603
tert-butyl 4-[pyrimidin-4-ylmethyl(5,6,7,8-tetrahydroquinolin-8-yl)amino]piperazine-1-carboxylate
   Show/Hide
C23H32N6O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0569825
N-methyl-N-[[6-(4-methylpiperazin-1-yl)pyridin-2-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C21H29N5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0533970
N-[[2-(dimethylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]methyl]-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C22H33N7
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0544468
2-[methyl-[2-methyl-6-[[methyl-[(8S)-5,6,7,8-tetrahydroquinolin-8-yl]amino]methyl]pyrimidin-4-yl]amino]ethanol
   Show/Hide
C19H27N5O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0570379
N-methyl-N-[[6-(4-methylpiperazin-1-yl)-2-pyrrolidin-1-ylpyrimidin-4-yl]methyl]-5,6,7,8-tetrahydroquinolin-8-amine
   Show/Hide
C24H35N7
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0558015
2-methyl-4-(4-methylpiperazin-1-yl)-6-[[(2R)-2-pyridin-2-ylpyrrolidin-1-yl]methyl]pyrimidine
   Show/Hide
C20H28N6
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS