Brief Information of the Cell Line and Protein
Cell Line ID: CL000685 , HEK-Blue hTLR9
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_IM86
Protein ID: PT01922 , Toll-like receptor 9
Gene Name TLR9
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q9NR96
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000685  Protein ID: PT01922
 
Compound ID Compound Name Compound Formula
CP0543579
2-(2,4-dimethoxyphenyl)-7-(4-propan-2-ylpiperazin-1-yl)-3-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridine
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C27H37N5O2
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0543577
7-(4-cyclopentylpiperazin-1-yl)-2-[4-methoxy-2-(3-pyrrolidin-1-ylpropoxy)phenyl]imidazo[1,2-a]pyridine
   Show/Hide
C30H41N5O2
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0568601
2-(2,4-dimethoxyphenyl)-N-(3-pyrrolidin-1-ylpropyl)imidazo[1,2-a]pyridin-7-amine
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C22H28N4O2
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0575651
4-[3-[2-[7-(4-cyclopentylpiperazin-1-yl)imidazo[1,2-a]pyridin-2-yl]-5-methoxyphenoxy]propyl]morpholine
   Show/Hide
C30H41N5O3
 1
1
IC50 = 28 nM
   TI
   LI
   LO
   TS
CP0574396
2-deuterio-5-[(2R,6S)-2-methyl-6-[[6-(5-oxa-2,8-diazaspiro[3.5]nonan-2-yl)spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]methyl]morpholin-4-yl]quinoline-8-carbonitrile
   Show/Hide
C32H36N6O3
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0575548
4-[(2R,6S)-2-methyl-6-[[6-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]methyl]morpholin-4-yl]pyrazolo[1,5-a]pyridine-7-carbonitrile
   Show/Hide
C30H35N7O2
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0577503
4-[3-[5-methoxy-2-(7-piperazin-1-ylimidazo[1,2-a]pyridin-2-yl)phenoxy]propyl]morpholine
   Show/Hide
C25H33N5O3
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0578863
2-(2,4-dimethoxyphenyl)-N-(3-imidazol-1-ylpropyl)imidazo[1,2-a]pyridin-7-amine
   Show/Hide
C21H23N5O2
 1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
CP0574188
5-[(2S,6R)-2-[[3-[(4aR,7aR)-3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazin-6-yl]spiro[5H-furo[3,4-b]pyridine-7,3'-azetidine]-1'-yl]methyl]-6-methylmorpholin-4-yl]-2-deuterioquinoline-8-carbonitrile
   Show/Hide
C31H35N7O3
 1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
CP0575652
7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)-3-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridine
   Show/Hide
C29H39N5O2
 1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
CP0531630
2-(2,6-dimethylpyridin-4-yl)-4-methyl-6-piperidin-4-yl-9H-carbazole
   Show/Hide
C25H27N3
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0567442
5-[(2S,6R)-2-[[6-(3-amino-3-methylazetidin-1-yl)spiro[1H-furo[3,4-c]pyridine-3,3'-azetidine]-1'-yl]methyl]-6-methylmorpholin-4-yl]-2-deuterioquinoline-8-carbonitrile
   Show/Hide
C29H33N7O2
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0569971
2-(2,4-dimethoxyphenyl)-7-(4-propan-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridine
   Show/Hide
C22H28N4O2
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0571057
4-[[2-(2,4-dimethoxyphenyl)-7-(4-propan-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholine
   Show/Hide
C27H37N5O3
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0569013
2-(4-methoxyphenyl)-7-(4-propan-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridine
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C21H26N4O
 1
1
IC50 = 44 nM
   TI
   LI
   LO
   TS
CP0543564
2-(2,4-dimethoxyphenyl)-7-piperazin-1-ylimidazo[1,2-a]pyridine
   Show/Hide
C19H22N4O2
 1
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
CP0528326
5-[(4R,9aS)-8-[2-[6-[(3R,4S)-3-amino-4-fluoropyrrolidin-1-yl]pyridin-3-yl]ethyl]-4-methyl-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]quinoline-8-carbonitrile
   Show/Hide
C29H35FN8
 1
1
IC50 = 47 nM
   TI
   LI
   LO
   TS
CP0571056
7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridine
   Show/Hide
C24H30N4O2
 1
1
IC50 = 49 nM
   TI
   LI
   LO
   TS
CP0573978
2-(2,4-dimethoxyphenyl)-N-(2-morpholin-4-ylethyl)imidazo[1,2-a]pyridin-7-amine
   Show/Hide
C21H26N4O3
 1
1
IC50 = 49 nM
   TI
   LI
   LO
   TS
CP0528325
5-[(4R,9aS)-4-methyl-8-(5,6,7,8-tetrahydro-2,7-naphthyridin-4-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]quinoline-8-carbonitrile
   Show/Hide
C26H29N7
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0547488
5-[(4R,9aR)-4-methyl-8-(5,6,7,8-tetrahydro-2,7-naphthyridin-4-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]quinoline-8-carbonitrile
   Show/Hide
C26H29N7
 1
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
CP0574456
5-[(2S,6R)-2-[[6-(3-amino-3-methylazetidin-1-yl)spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]methyl]-6-methylmorpholin-4-yl]-2-deuterioquinoline-8-carbonitrile
   Show/Hide
C30H34N6O2
 1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
CP0492437
2-(2,6-dimethylpyridin-4-yl)-6-piperidin-4-yl-9H-carbazole
   Show/Hide
C24H25N3
 1
1
IC50 = 53 nM
   TI
   LI
   LO
   TS
CP0444745
2-deuterio-5-[(2S,6R)-11-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-6-methyl-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile
   Show/Hide
C26H27N7
 1
1
IC50 = 53.4 nM
   TI
   LI
   LO
   TS
CP0535144
5-[(4R,9aS)-4-methyl-8-(1,2,3,4-tetrahydroisoquinolin-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]quinoline-8-carbonitrile
   Show/Hide
C27H30N6
 1
1
IC50 = 54 nM
   TI
   LI
   LO
   TS
CP0543565
2-(4-methoxy-2-phenylmethoxyphenyl)-7-piperazin-1-ylimidazo[1,2-a]pyridine
   Show/Hide
C25H26N4O2
 1
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
CP0451274
5-[(2R)-11-(4-amino-4-methylpiperidin-1-yl)-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile
   Show/Hide
C26H29N7
 1
1
IC50 = 56.6 nM
   TI
   LI
   LO
   TS
CP0575862
5-[(2S,6R)-2-[[6-(3-aminoazetidin-1-yl)spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]methyl]-6-methylmorpholin-4-yl]-2-deuterioquinoline-8-carbonitrile
   Show/Hide
C29H32N6O2
 1
1
IC50 = 57 nM
   TI
   LI
   LO
   TS
CP0548364
1-[4-[7-(2,6-dimethylpyridin-4-yl)-5-methyl-9H-carbazol-3-yl]piperidin-1-yl]-2-methylpropan-2-ol
   Show/Hide
C29H35N3O
 1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
CP0543570
2-(4-methoxyphenyl)-N-(3-morpholin-4-ylpropyl)imidazo[1,2-a]pyridin-7-amine
   Show/Hide
C21H26N4O2
 1
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
CP0570257
2-(2,4-dimethoxyphenyl)-N-(3-morpholin-4-ylpropyl)imidazo[1,2-a]pyridin-7-amine
   Show/Hide
C22H28N4O3
 1
1
IC50 = 69 nM
   TI
   LI
   LO
   TS
CP0535145
5-[(4S)-8-[5-[(6R)-6-amino-1,4-oxazepan-4-yl]-3-methylpyridin-2-yl]-4-methyl-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]-2-deuterioquinoline-8-carbonitrile
   Show/Hide
C29H36N8O
 1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0571055
7-(4-cyclopentylpiperazin-1-yl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine
   Show/Hide
C23H28N4O
 1
1
IC50 = 71 nM
   TI
   LI
   LO
   TS
CP0535450
5-[(4R,9aR)-8-[5-(6-amino-2-azaspiro[3.3]heptan-2-yl)-3-methylpyridin-2-yl]-4-methyl-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]-2-deuterioquinoline-8-carbonitrile
   Show/Hide
C30H36N8
 1
1
IC50 = 81 nM
   TI
   LI
   LO
   TS
CP0543575
2-[4-methoxy-2-(3-pyrrolidin-1-ylpropoxy)phenyl]-7-piperazin-1-ylimidazo[1,2-a]pyridine
   Show/Hide
C25H33N5O2
 1
1
IC50 = 94 nM
   TI
   LI
   LO
   TS
CP0540408
2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3,4-dimethyl-6-piperidin-4-yl-9H-carbazole
   Show/Hide
C26H27N5O
 1
1
IC50 = 95 nM
   TI
   LI
   LO
   TS
CP0562123
2-deuterio-5-[(2S,6R)-11-(2,6-diazaspiro[3.4]octan-6-yl)-6-methyl-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile
   Show/Hide
C27H29N7
 1
1
IC50 = 105.7 nM
   TI
   LI
   LO
   TS
CP0553529
2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-methyl-6-piperidin-4-yl-9H-carbazole
   Show/Hide
C25H25N5O
 1
1
IC50 = 108 nM
   TI
   LI
   LO
   TS
CP0548297
2-deuterio-5-[(2S,6R)-6-methyl-11-piperidin-4-yloxy-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile
   Show/Hide
C26H28N6O
 1
1
IC50 = 118 nM
   TI
   LI
   LO
   TS
CP0534086
2-deuterio-5-[(2S,6R)-11-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-6-methyl-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile
   Show/Hide
C26H27N7
 1
1
IC50 = 120.9 nM
   TI
   LI
   LO
   TS
CP0451275
5-[(2S,6R)-11-[(3S)-3-amino-3-methylpyrrolidin-1-yl]-6-methyl-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]-2-deuterioquinoline-8-carbonitrile
   Show/Hide
C26H29N7
 1
1
IC50 = 138.9 nM
   TI
   LI
   LO
   TS
CP0569973
4-[[7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholine
   Show/Hide
C29H39N5O3
 1
1
IC50 = 142 nM
   TI
   LI
   LO
   TS
CP0492436
2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-methyl-6-piperidin-4-yl-9H-carbazole
   Show/Hide
C25H25N5O
 1
1
IC50 = 153 nM
   TI
   LI
   LO
   TS
CP0543571
7-(4-cyclopentylpiperazin-1-yl)-2-(4-methoxy-2-phenylmethoxyphenyl)imidazo[1,2-a]pyridine
   Show/Hide
C30H34N4O2
 1
1
IC50 = 153 nM
   TI
   LI
   LO
   TS
CP0569972
tert-butyl 4-[2-[4-methoxy-2-(3-pyrrolidin-1-ylpropoxy)phenyl]imidazo[1,2-a]pyridin-7-yl]piperazine-1-carboxylate
   Show/Hide
C30H41N5O4
 1
1
IC50 = 157 nM
   TI
   LI
   LO
   TS
CP0543567
7-(4-cyclopentylpiperazin-1-yl)-2-(4-methoxy-2-phenylmethoxyphenyl)-3-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridine
   Show/Hide
C35H43N5O2
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0569189
2-[7-(4-cyclopentylpiperazin-1-yl)-3-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin-2-yl]-5-methoxyphenol
   Show/Hide
C28H37N5O2
 1
1
IC50 = 245 nM
   TI
   LI
   LO
   TS
CP0543574
tert-butyl 4-[2-[4-methoxy-2-(3-morpholin-4-ylpropoxy)phenyl]imidazo[1,2-a]pyridin-7-yl]piperazine-1-carboxylate
   Show/Hide
C30H41N5O5
 1
1
IC50 = 314 nM
   TI
   LI
   LO
   TS
CP0543566
N-benzyl-7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-3-amine
   Show/Hide
C31H37N5O2
 1
1
IC50 = 526 nM
   TI
   LI
   LO
   TS
CP0573977
2-(2,4-dimethoxyphenyl)-N,N-dimethylimidazo[1,2-a]pyridin-7-amine
   Show/Hide
C17H19N3O2
 1
1
IC50 = 766 nM
   TI
   LI
   LO
   TS
CP0568599
2-[7-(4-cyclopentylpiperazin-1-yl)imidazo[1,2-a]pyridin-2-yl]-5-methoxyphenol
   Show/Hide
C23H28N4O2
 1
1
IC50 = 790 nM
   TI
   LI
   LO
   TS
CP0543563
2-(4-methoxyphenyl)-7-piperazin-1-ylimidazo[1,2-a]pyridine
   Show/Hide
C18H20N4O
 1
1
IC50 = 803 nM
   TI
   LI
   LO
   TS
CP0577504
[4-[2-(4-methoxy-2-phenylmethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]-phenylmethanone
   Show/Hide
C32H30N4O3
 1
1
IC50 = 1060 nM
   TI
   LI
   LO
   TS
CP0567938
cyclopentyl-[4-[2-(2,4-dimethoxyphenyl)-3-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]methanone
   Show/Hide
C30H39N5O3
 1
1
IC50 = 1120 nM
   TI
   LI
   LO
   TS
CP0543569
2-(4-methoxyphenyl)-N,N-dimethylimidazo[1,2-a]pyridin-7-amine
   Show/Hide
C16H17N3O
 1
1
IC50 = 1480 nM
   TI
   LI
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CP0543568
2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-amine
   Show/Hide
C15H15N3O2
 1
1
IC50 = 1570 nM
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CP0543578
N-cyclohexyl-7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-3-amine
   Show/Hide
C30H41N5O2
 1
1
IC50 = 2110 nM
   TI
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CP0570259
cyclopentyl-[4-[2-(2-hydroxy-4-methoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]methanone
   Show/Hide
C24H28N4O3
 1
1
IC50 = 2120 nM
   TI
   LI
   LO
   TS
CP0543573
(4-fluorophenyl)-[4-[2-(4-methoxy-2-phenylmethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]methanone
   Show/Hide
C32H29FN4O3
 1
1
IC50 = 2190 nM
   TI
   LI
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   TS
CP0572659
N,N-dimethyl-2-phenylimidazo[1,2-a]pyridin-7-amine
   Show/Hide
C15H15N3
 1
1
IC50 = 2190 nM
   TI
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   TS
CP0569012
cyclopentyl-[4-[2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]methanone
   Show/Hide
C25H30N4O3
 1
1
IC50 = 2910 nM
   TI
   LI
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   TS
CP0571664
2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-7-amine
   Show/Hide
C14H13N3O
 1
1
IC50 = 2920 nM
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CP0577024
cyclopentyl-[4-[2-(4-methoxy-2-phenylmethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]methanone
   Show/Hide
C31H34N4O3
 1
1
IC50 = 5130 nM
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CP0577625
2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridine
   Show/Hide
C15H14N2O2
 1
1
IC50 = 10430 nM
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