Brief Information of the Cell Line and Protein
Cell Line ID: CL000035 , NIH 3T3
Synonyms
NIH/3T3
NIH-3T3
NIH3T3
3T3
3T3NIH
3T3-Swiss
Swiss-3T3
Swiss/3T3
Swiss 3T3
Swiss3T3
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_0594
Protein ID: PT01198 , Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P08172
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000035  Protein ID: PT01198
 
Compound ID Compound Name Compound Formula
CP0395274
(E)-N-[(Z)-5-(3,4-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C20H24N2O3
 1
1
ED50 = 0.9 nM
   TI
   LI
   LO
   TS
CP0404047
(Z)-N-[(E)-5-(3,4-dimethoxyphenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C20H24N2O3
 1
1
ED50 = 1.8 nM
   TI
   LI
   LO
   TS
CP0395297
(Z)-N-[(Z)-3-methyl-5-thiophen-2-ylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C16H18N2OS
 1
1
ED50 = 2.3 nM
   TI
   LI
   LO
   TS
CP0453267
(E)-N-[(Z)-3-methyl-5-thiophen-2-ylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C16H18N2OS
 1
1
ED50 = 2.5 nM
   TI
   LI
   LO
   TS
CP0443854
(E)-N-[(Z)-5-(4-chlorophenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C18H19ClN2O
 1
1
ED50 = 2.8 nM
   TI
   LI
   LO
   TS
CP0409582
(Z)-N-[(Z)-5-(4-fluorophenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C18H19FN2O
 1
1
ED50 = 3 nM
   TI
   LI
   LO
   TS
CP0377667
(E)-N-[(Z)-3-methyl-5-phenylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C18H20N2O
 1
1
ED50 = 4.2 nM
   TI
   LI
   LO
   TS
CP0403968
(E)-N-[(Z)-3-methyl-5-(4-methylphenyl)pent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C19H22N2O
 1
1
ED50 = 4.4 nM
   TI
   LI
   LO
   TS
CP0443852
(Z)-N-[(Z)-5-(3-methoxyphenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C19H22N2O2
 1
1
ED50 = 4.5 nM
   TI
   LI
   LO
   TS
CP0397403
(Z)-N-[(Z)-5-(4-methoxyphenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C19H22N2O2
 1
1
ED50 = 8.9 nM
   TI
   LI
   LO
   TS
CP0409619
(Z)-N-[(E)-5-(4-fluorophenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C18H19FN2O
 1
1
ED50 = 9.1 nM
   TI
   LI
   LO
   TS
CP0449011
(E)-N-[(Z)-5-(4-methoxyphenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C19H22N2O2
 1
1
ED50 = 10.7 nM
   TI
   LI
   LO
   TS
CP0470884
(Z)-N-[(Z)-3-methyl-5-(4-methylphenyl)pent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C19H22N2O
 1
1
ED50 = 10.7 nM
   TI
   LI
   LO
   TS
CP0372937
1-Aza-bicyclo[2.2.1]heptan-3-one O-((E)-3-methyl-pent-2-en-4-ynyl)-oxime
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C12H16N2O
 1
1
ED50 = 11 nM
   TI
   LI
   LO
   TS
CP0420383
(E)-N-[(E)-5-(3-methoxyphenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C19H22N2O2
 1
1
ED50 = 12.4 nM
   TI
   LI
   LO
   TS
CP0635477
(2-Carbamoyloxy-ethyl)-trimethyl-ammonium chloride
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C6H15ClN2O2
 1
1
ED50 = 22.8 nM
   TI
   LI
   LO
   TS
CP0404732
1-Aza-bicyclo[2.2.1]heptan-3-one O-((Z)-3-methyl-pent-2-en-4-ynyl)-oxime
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C12H16N2O
 1
1
ED50 = 23.7 nM
   TI
   LI
   LO
   TS
CP0397590
(Z)-N-[(E)-3-methyl-5-thiophen-2-ylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C16H18N2OS
 1
1
ED50 = 24 nM
   TI
   LI
   LO
   TS
CP0397593
(E)-N-[(Z)-5-(3-methoxyphenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C19H22N2O2
 1
1
ED50 = 28.2 nM
   TI
   LI
   LO
   TS
CP0397589
(Z)-N-[(E)-5-(3-methoxyphenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C19H22N2O2
 1
1
ED50 = 42.3 nM
   TI
   LI
   LO
   TS
CP0395089
(E)-N-[(Z)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C12H16N2O
 1
1
ED50 = 45 nM
   TI
   LI
   LO
   TS
CP0377665
(E)-N-[(Z)-5-(4-fluorophenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C18H19FN2O
 1
1
ED50 = 270 nM
   TI
   LI
   LO
   TS
CP0395259
(E)-N-[(E)-5-(4-fluorophenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C18H19FN2O
 1
1
ED50 = 456 nM
   TI
   LI
   LO
   TS
CP0395070
(Z)-N-[(E)-5-(3,4-dichlorophenyl)-3-methylpent-2-en-4-ynoxy]-1-azabicyclo[2.2.1]heptan-3-imine
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C18H18Cl2N2O
 1
1
ED50 = 940 nM
   TI
   LI
   LO
   TS
CP0847194
(R)-1-Aza-bicyclo[2.2.1]heptan-3-one O-[3-(3-methoxy-phenyl)-prop-2-ynyl]-oxime
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C16H18N2O2
 1
1
ED50 = 1283 nM
   TI
   LI
   LO
   TS
CP0382879
1-Aza-bicyclo[2.2.1]heptan-3-one O-[3-(3-methoxy-phenyl)-prop-2-ynyl]-oxime
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C16H18N2O2
 1
1
ED50 = 1322 nM
   TI
   LI
   LO
   TS