Brief Information of the Cell Line and Protein
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Synonyms
SF21
Sf-21
SF-21
IPLB-SF-21-AE
IPLB-Sf21-AE
IPLB-SF21-AE
IPLB-SF 21AE
IPLB-Sf21AE
IPLB-SF21AE
IPLB-SF-21
IPLB-Sf-21
IPLB-SF 21
IPLB-Sf21
IPLB-SF21
Category Spontaneously immortalized cell line
Organism
Spodoptera frugiperda (Fall armyworm)
Cellosaurus ID
CVCL_0518
Protein ID: PT01022 , RAC-gamma serine/threonine-protein kinase
 Protein Info 
Gene Name AKT3
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q9Y243
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000012
 Cell Line Info 
 Protein ID: PT01022
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0569793
 Compound Info 
(4S)-5-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
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C24H29ClN6O3
  1
1
IC50 = 0.1 nM
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CP0576003
 Compound Info 
(5R)-4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H31ClN6O2
  1
1
IC50 = 0.1 nM
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CP0577114
 Compound Info 
(5R)-4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(cyclopropylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H29ClN6O2
  1
1
IC50 = 0.1 nM
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CP0543716
 Compound Info 
(4S)-5-[(1R,5S)-3-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
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C25H31ClN6O3
  1
1
IC50 = 0.2 nM
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CP0576733
 Compound Info 
(5R)-4-[8-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C26H33ClN6O2
  1
1
IC50 = 0.2 nM
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CP0577369
 Compound Info 
4-[8-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-5-methyl-6,8-dihydropteridin-7-one;formic acid
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C26H34ClN7O4
  1
1
IC50 = 0.2 nM
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CP0578923
 Compound Info 
(4S)-5-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
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C23H29ClN6O3
  1
1
IC50 = 0.2 nM
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CP0965432
 Compound Info 
(R)-4-(4-((S)-2-(4-chlorophenyl)-3-(isopropylamino)propanoyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
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C24H31ClN6O2
  1
1
IC50 = 0.2 nM
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CP0545494
 Compound Info 
(5R)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C24H31ClN6O2
  1
1
IC50 = 0.3 nM
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CP0577366
 Compound Info 
(5R)-4-[3-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C26H33ClN6O2
  1
1
IC50 = 0.3 nM
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CP0568350
 Compound Info 
(4S)-5-[(1R,5S)-8-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
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C25H31ClN6O3
  1
1
IC50 = 0.4 nM
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CP0571317
 Compound Info 
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-6,8-dihydropteridin-7-one;hydrochloride
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C23H31Cl2N7O2
  1
1
IC50 = 0.4 nM
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CP0543699
 Compound Info 
4-[(1R,5S)-3-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-5-methyl-6,8-dihydropteridin-7-one
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C25H32ClN7O2
  1
1
IC50 = 0.5 nM
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CP0571316
 Compound Info 
(5R)-4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-[(4-methoxycyclohexyl)amino]propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C29H37ClN6O3
  1
1
IC50 = 0.5 nM
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CP0578377
 Compound Info 
4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydropteridin-7-one
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C24H30ClN7O2
  1
1
IC50 = 0.5 nM
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CP0577367
 Compound Info 
(5R)-4-[(1S,6R)-5-[(2S)-3-amino-2-(4-chlorophenyl)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C22H25ClN6O2
  1
1
IC50 = 0.7 nM
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CP0579115
 Compound Info 
(5R)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-(trifluoromethyl)-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C24H28ClF3N6O2
  1
1
IC50 = 1 nM
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CP0569440
 Compound Info 
5-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one
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C23H29ClN6O3
  1
1
IC50 = 1.2 nM
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CP0573075
 Compound Info 
(5R)-4-[(1S,6R)-5-[(2S)-2-(4-chlorophenyl)-3-(3-oxabicyclo[3.1.0]hexan-6-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C27H31ClN6O3
  1
1
IC50 = 1.2 nM
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CP0552081
 Compound Info 
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C24H31ClN6O2
  1
1
IC50 = 1.6 nM
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CP0577368
 Compound Info 
(5R)-4-[(3R)-4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3-methylpiperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H33ClN6O2
  1
1
IC50 = 2.6 nM
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CP0547250
 Compound Info 
(5R)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-4,7-diazaspiro[2.5]octan-7-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C26H33ClN6O2
  1
1
IC50 = 4.4 nM
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CP0543850
 Compound Info 
(5R)-4-[(3aR,6aS)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C26H33ClN6O2
  1
1
IC50 = 6.6 nM
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CP0569441
 Compound Info 
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C23H29ClN6O2
  1
1
IC50 = 7.4 nM
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CP0577102
 Compound Info 
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one;hydrochloride
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C24H32Cl2N6O2
  1
1
IC50 = 7.4 nM
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CP0578352
 Compound Info 
(5R)-4-[(2R)-4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2-methylpiperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H33ClN6O2
  1
1
IC50 = 7.5 nM
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CP0568923
 Compound Info 
(5R)-4-[(3S)-4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3-methylpiperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one;formic acid
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C26H35ClN6O4
  1
1
IC50 = 8.5 nM
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CP0547235
 Compound Info 
(6S)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C24H31ClN6O2
  1
1
IC50 = 9.1 nM
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CP0550487
 Compound Info 
(2R,4S)-11-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6,8,10-triazatricyclo[5.4.0.02,4]undeca-1(7),8,10-trien-5-one
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C24H29ClN6O2
  1
1
IC50 = 12 nM
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CP0550489
 Compound Info 
(5R)-4-[(1R,6S)-5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[4.1.0]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H31ClN6O2
  1
1
IC50 = 13 nM
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CP0570248
 Compound Info 
(6R)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C24H31ClN6O2
  1
1
IC50 = 18 nM
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CP0088096
 Compound Info 
(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
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C24H32ClN5O2
  1
1
IC50 = 22 nM
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CP0545500
 Compound Info 
(5R)-4-[1-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-3,6-dihydro-2H-pyridin-4-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H30ClN5O2
  1
1
IC50 = 24 nM
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CP0552089
 Compound Info 
(4R)-5-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-4-methyl-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one;formic acid
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C24H31ClN6O5
  1
1
IC50 = 42 nM
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CP0552082
 Compound Info 
(5R)-4-[5-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,5-diazabicyclo[2.2.1]heptan-2-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H31ClN6O2
  1
1
IC50 = 60 nM
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CP0550443
 Compound Info 
(2S,4R)-11-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-6,8,10-triazatricyclo[5.4.0.02,4]undeca-1(7),8,10-trien-5-one
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C24H29ClN6O2
  1
1
IC50 = 61 nM
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CP0571318
 Compound Info 
(5S)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-(trifluoromethyl)-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C24H28ClF3N6O2
  1
1
IC50 = 135 nM
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CP0579114
 Compound Info 
(5S)-4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C24H31ClN6O2
  1
1
IC50 = 160 nM
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CP0569439
 Compound Info 
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-5-methyl-7,8-dihydropteridin-6-one
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C23H30ClN7O2
  1
1
IC50 = 212 nM
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CP0550463
 Compound Info 
(5R)-4-[1-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperidin-4-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H32ClN5O2
  1
1
IC50 = 661 nM
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CP0545487
 Compound Info 
(5R)-4-[2-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]-2,6-diazaspiro[3.3]heptan-6-yl]-5-methyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-7-one
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C25H31ClN6O2
  1
1
IC50 = 953 nM
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CP0576731
 Compound Info 
(2S)-2-(4-chlorophenyl)-1-[4-[6-(hydroxymethyl)-5-methylpyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
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C22H30ClN5O2
  1
1
IC50 > 1000 nM
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CP0576732
 Compound Info 
4-[4-[(2S)-2-(4-chlorophenyl)-3-(propan-2-ylamino)propanoyl]piperazin-1-yl]-1H-pyridin-2-one
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C21H27ClN4O2
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1
IC50 > 1000 nM
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