Compound ID |
Compound Name |
Compound Formula |
CP0861760
|
(+/-)-3-(6-Fluoro-1H-indazol-3-ylmethylene)-1-[2-oxoethyl-2-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)]-5-phenyl-1H-1,5-diazepine-2,4-dione
Show/Hide
|
C31H28FN5O3
|
1
|
1 |
EC50 = 1.585 nM
|
|
|
CP0874344
|
(+/-)-2-[2,4-Dioxo-3-(6-fluoro-1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
|
C31H30FN5O4
|
1
|
1 |
EC50 = 1.585 nM
|
|
|
CP0874693
|
(+/-)-3-(1H-Indazol-3-ylmethylene)-1-[2-oxoethyl-2-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)]-5-phenyl-1H-1,5-diazepine-2,4-dione
Show/Hide
|
C31H29N5O3
|
1
|
1 |
EC50 = 1.585 nM
|
|
|
CP0885254
|
(R)-3-(1H-Indazol-3-ylmethylene)-1-[2-oxoethyl-2-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)]-5-phenyl-1H-1,5-diazepine-2,4-dione
Show/Hide
|
C31H29N5O3
|
1
|
1 |
EC50 = 1.585 nM
|
|
|
CP0844893
|
Ac-Nle4-cyclo(Asp5-His6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
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|
C56H70N12O9
|
2
|
1 |
EC50 = 3.3 nM
|
|
|
2 |
IC50 = 5.9 nM
|
|
|
CP0394757
|
Ac-Nle4-cyclo(Asp5-His6-D-4,4'-Bip-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C56H69N11O9
|
2
|
1 |
EC50 = 5.3 nM
|
|
|
2 |
IC50 = 45 nM
|
|
|
CP0847012
|
(+/-)-2-[6-(6-Fluoro-1H-indazol-3-ylmethylene)-5,7-dioxo-4-(3-pyridinyl)-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl]-N-(1-methylethyl)-N-[4-(methyloxy)phenyl]acetamide
Show/Hide
|
C30H29FN6O4
|
1
|
1 |
EC50 = 12.59 nM
|
|
|
CP0846974
|
(+/-)-2-[2,4-Dioxo-3-(6-fluoro-1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-fluorophenyl)-N-isopropylacetamide
Show/Hide
|
C30H27F2N5O3
|
1
|
1 |
EC50 = 14.13 nM
|
|
|
CP0897229
|
(R)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
|
C31H31N5O4
|
1
|
1 |
EC50 = 15.85 nM
|
|
|
CP0873909
|
(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-(2-methyl-4-trifluoromethoxy)phenyl)acetamide
Show/Hide
|
C31H28F3N5O4
|
1
|
1 |
EC50 = 22.39 nM
|
|
|
CP0876125
|
Ac-Nle4-cyclo(Asp5-Pro6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C55H70N10O9
|
2
|
1 |
EC50 = 28 nM
|
|
|
2 |
IC50 = 65 nM
|
|
|
CP0885253
|
(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
|
C31H31N5O4
|
1
|
1 |
EC50 = 29.51 nM
|
|
|
CP0921840
|
(R)-2-[2,4-Dioxo-3-(6-fluoro-1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-phenylacetamide
Show/Hide
|
C30H28FN5O3
|
1
|
1 |
EC50 = 35.48 nM
|
|
|
CP0394108
|
Ac-Nle4-cyclo(Asp5-His6-D-Tyr(Me)-Pro8-Trp9-Lys10)-NH2
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|
C50H66N12O10
|
2
|
1 |
EC50 = 50 nM
|
|
|
2 |
IC50 = 500 nM
|
|
|
CP0874312
|
(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-fluorophenyl)-Nisopropylacetamide
Show/Hide
|
C30H28FN5O3
|
1
|
1 |
EC50 = 50.12 nM
|
|
|
CP0853038
|
(2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3.4.5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-hydroxyphenyl)-N-isopropylacetamide hydrobromide
Show/Hide
|
C30H30BrN5O4
|
1
|
1 |
EC50 = 52.48 nM
|
|
|
CP0425195
|
Ac-Nle4-cyclo(Asp5-His6-D-Tyr(Et)-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C51H68N12O10
|
2
|
1 |
EC50 = 60 nM
|
|
|
2 |
IC50 = 430 nM
|
|
|
CP0873910
|
(S)-3-(1H-Indazol-3-ylmethylene)-1-[2-oxoethyl-2-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)]-5-phenyl-1H-1,5-diazepine-2,4-dione
Show/Hide
|
C31H29N5O3
|
1
|
1 |
EC50 = 61.66 nM
|
|
|
CP0394150
|
Ac-Nle4-cyclo(Asp5-His6-D-Phe(4-Cl)-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H63ClN12O9
|
2
|
1 |
EC50 = 63 nM
|
|
|
2 |
IC50 = 560 nM
|
|
|
CP0425206
|
Ac-Nle4-cyclo(Asp5-His6-D-Nal(2)-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C53H66N12O9
|
2
|
1 |
EC50 = 89 nM
|
|
|
2 |
IC50 = 880 nM
|
|
|
CP0876424
|
c-Nle4-cyclo(Asp5-Tic6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C60H72N10O9
|
2
|
1 |
EC50 = 130 nM
|
|
|
2 |
IC50 = 710 nM
|
|
|
CP0874311
|
2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3.4.5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-hydroxyphenyl)-N-isopropylacetamide hydrochloride
Show/Hide
|
C30H30ClN5O4
|
1
|
1 |
EC50 = 158.49 nM
|
|
|
CP0873848
|
(+/-)-2-[6-(1H-Indazol-3-ylmethyl)-5,7-dioxo-4-(3-pyridinyl)-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl]-N-(1-methylethyl)-N-[4-(methyloxy)phenyl]acetamide
Show/Hide
|
C30H30N6O4
|
1
|
1 |
EC50 = 177.83 nM
|
|
|
CP0847013
|
(+/-)-2-[2,4-Dioxo-3-(6-fluoro-1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-phenylacetamide
Show/Hide
|
C30H28FN5O3
|
1
|
1 |
EC50 = 186.21 nM
|
|
|
CP0422856
|
(3S,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
Show/Hide
|
C32H50FN5O3
|
2
|
1 |
EC50 = 250 nM
|
|
|
2 |
IC50 = 3300 nM
|
|
|
CP0378158
|
(3R,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
Show/Hide
|
C32H50FN5O3
|
2
|
1 |
EC50 = 260 nM
|
|
|
2 |
IC50 = 2100 nM
|
|
|
CP0378160
|
(3S,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-chlorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
Show/Hide
|
C32H50ClN5O3
|
2
|
1 |
EC50 = 280 nM
|
|
|
2 |
IC50 = 1500 nM
|
|
|
CP0848954
|
(R)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-Nphenylacetamide
Show/Hide
|
C30H29N5O3
|
1
|
1 |
EC50 = 295.12 nM
|
|
|
CP0394113
|
Ac-Nle4-cyclo(Asp5-His6-D-Bth-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C53H68N12O9S
|
2
|
1 |
EC50 = 300 nM
|
|
|
2 |
IC50 = 2200 nM
|
|
|
CP0882669
|
Ac-Nle4-cyclo(Asp5-Val6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C55H72N10O9
|
2
|
1 |
EC50 = 330 nM
|
|
|
2 |
IC50 = 4900 nM
|
|
|
CP0878544
|
Ac-Nle4-cyclo(Asp5-Pro6-D-4,4'-Bip7-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C54H68N10O9
|
2
|
1 |
EC50 = 350 nM
|
|
|
2 |
IC50 = 2100 nM
|
|
|
CP0378171
|
(S)-4-Methyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
Show/Hide
|
C31H48FN5O3
|
2
|
1 |
EC50 = 350 nM
|
|
|
2 |
IC50 = 1700 nM
|
|
|
CP0885306
|
(+/-)-2-(6-((1H-indazol-3-yl)methyl)-6-((1H-pyrazol-3-yl)methyl)-5,7-dioxo-4-phenyl-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl)-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
|
C35H35N7O4
|
1
|
1 |
EC50 = 398.11 nM
|
|
|
CP0378159
|
(3R,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-diethylpiperazine-1-carboxamide
Show/Hide
|
C34H54FN5O3
|
2
|
1 |
EC50 = 400 nM
|
|
|
2 |
IC50 = 2800 nM
|
|
|
CP0462980
|
(3R,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-diethylpiperazine-1-carboxamide
Show/Hide
|
C34H54FN5O3
|
2
|
1 |
EC50 = 420 nM
|
|
|
2 |
IC50 = 2100 nM
|
|
|
CP0400320
|
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N,1-di(propan-2-yl)pyrazole-4-carboxamide
Show/Hide
|
C37H56F2N6O2
|
2
|
1 |
EC50 = 520 nM
|
|
|
2 |
IC50 = 730 nM
|
|
|
CP0431963
|
Ac-Nle4-cyclo(Asp5-His6-D-2-Thi-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C47H62N12O9S
|
2
|
1 |
EC50 = 540 nM
|
|
|
2 |
IC50 > 5000 nM
|
|
|
CP0382833
|
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylmethanesulfonamide
Show/Hide
|
C31H50F2N4O3S
|
2
|
1 |
EC50 = 540 nM
|
|
|
2 |
IC50 = 1000 nM
|
|
|
CP0381200
|
N-(4-hydroxyphenyl)-2-[6-(2H-indazol-3-ylmethyl)-5,7-dioxo-4-phenyl-1,4-diazepin-1-yl]-N-propan-2-ylacetamide
Show/Hide
|
C30H29N5O4
|
1
|
1 |
EC50 = 549.54 nM
|
|
|
CP0400321
|
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-4-methylpentyl]-N-propan-2-ylacetamide
Show/Hide
|
C30H48F2N4O2
|
2
|
1 |
EC50 = 560 nM
|
|
|
2 |
IC50 = 3600 nM
|
|
|
CP0874694
|
(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-Nphenylacetamide
Show/Hide
|
C30H29N5O3
|
1
|
1 |
EC50 = 707.95 nM
|
|
|
CP0462697
|
(+/-)-2-[6-(1H-Indazol-3-ylmethyl)-5,7-dioxo-4-(phenylmethyl)-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl]-N-(1-methylethyl)-N-[4-(methyloxy)phenyl]acetamide
Show/Hide
|
C32H33N5O4
|
1
|
1 |
EC50 = 794.33 nM
|
|
|
CP0407464
|
(+/-)-2-[6-(1H-Indazol-3-ylmethyl)-5,7-dioxo-4-phenyl-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl]-N-(1-methylethyl)-N-[4-(4-morpholinyl)phenyl]acetamide
Show/Hide
|
C34H36N6O4
|
1
|
1 |
EC50 = 831.76 nM
|
|
|
CP0425204
|
Ac-Nle4-cyclo(Asp5-His6-D-Tyr-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C51H65N13O9
|
2
|
1 |
EC50 = 880 nM
|
|
|
2 |
IC50 > 5000 nM
|
|
|
CP0400322
|
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylacetamide
Show/Hide
|
C32H50F2N4O2
|
2
|
1 |
EC50 = 890 nM
|
|
|
2 |
IC50 = 1800 nM
|
|
|
CP0438966
|
(3R,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,4,5-trimethylpiperazine-1-carboxamide
Show/Hide
|
C33H52FN5O3
|
2
|
1 |
EC50 = 910 nM
|
|
|
2 |
IC50 = 7800 nM
|
|
|
CP0438920
|
(+/-)-2-(6-((1H-indazol-3-yl)methyl)-6-methoxy-5,7-dioxo-4-(thiophen-2-ylmethyl)-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl)-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
|
C31H33N5O5S
|
1
|
1 |
EC50 = 1174.9 nM
|
|
|
CP0382832
|
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylpyridazine-3-carboxamide
Show/Hide
|
C35H50F2N6O2
|
2
|
1 |
EC50 = 1200 nM
|
|
|
2 |
IC50 = 1900 nM
|
|
|
CP0422262
|
Ac-Nle4-cyclo(Asp5-His6-D-Phe-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H64N12O9
|
2
|
1 |
EC50 = 1300 nM
|
|
|
2 |
IC50 = 2500 nM
|
|
|
CP0846176
|
(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-3-methoxy-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-methoxyphenyl)N-isopropylacetamide
Show/Hide
|
C32H33N5O5
|
1
|
1 |
EC50 = 1380.38 nM
|
|
|
CP0429199
|
(S)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
|
C31H31N5O4
|
1
|
1 |
EC50 = 1548.82 nM
|
|
|
CP0874910
|
(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-3-methoxy-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-fluorophenyl)N-isopropylacetamide
Show/Hide
|
C31H30FN5O4
|
1
|
1 |
EC50 = 2951.21 nM
|
|
|
CP0381199
|
(+/-)-2-{6-[(6-Fluoro-1H-indazol-3-yl)methyl]-4-methyl-5,7-dioxo-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl}-N-(4-fluorophenyl)-N-(1-methylethyl)acetamide
Show/Hide
|
C25H25F2N5O3
|
1
|
1 |
EC50 = 3715.35 nM
|
|
|
CP0394111
|
Ac-Nle4-cyclo(Asp5-His6-D-Phe(No2)-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H63N13O11
|
2
|
1 |
EC50 > 500 nM
|
|
|
2 |
IC50 > 2000 nM
|
|
|
CP0855105
|
Ac-Nle4-cyclo(Asp5-Chg6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C58H76N10O9
|
2
|
1 |
EC50 > 500 nM
|
|
|
2 |
IC50 > 10000 nM
|
|
|
CP0432989
|
Ac-Nle4-cyclo(Asp5-His6-L-Phe-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H64N12O9
|
2
|
1 |
EC50 > 1000 nM
|
|
|
2 |
IC50 = 980 nM
|
|
|
CP0394112
|
Ac-Nle4-cyclo(Asp5-His6-D-Cha-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H70N12O9
|
2
|
1 |
EC50 > 2500 nM
|
|
|
2 |
IC50 > 10000 nM
|
|
|
CP0432988
|
Ac-Nle4-cyclo(Asp5-His6-D-Tyr-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H64N12O10
|
2
|
1 |
EC50 > 2500 nM
|
|
|
2 |
IC50 > 10000 nM
|
|
|
CP0855549
|
Ac-Nle4-cyclo(Asp5-Oic6-D-4,4'-Bip7-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C58H74N10O9
|
2
|
1 |
EC50 > 2500 nM
|
|
|
2 |
IC50 = 7800 nM
|
|
|
CP0400328
|
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-4-methylpentyl]-N-propan-2-ylmethanesulfonamide
Show/Hide
|
C29H48F2N4O3S
|
2
|
1 |
EC50 > 5000 nM
|
|
|
2 |
IC50 = 5000 nM
|
|
|
CP0493433
|
1-[(2R)-2-[(5-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulene-6-carbonyl)amino]-3-(4-chlorophenyl)propanoyl]-N-tert-butyl-4-cyclohexylpiperidine-4-carboxamide
Show/Hide
|
C37H51ClN4O3
|
1
|
1 |
IC50 = 220 nM
|
|
|
CP0150320
|
1-[(R)-2-[((1S,2S)-1-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
Show/Hide
|
C36H49ClN4O3
|
1
|
1 |
IC50 = 530 nM
|
|
|
CP0466894
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1-[(R)-2-[((1S,2S)-1-Amino-1-methyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
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C37H51ClN4O3
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1
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1 |
IC50 = 620 nM
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CP0497448
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1-[2-[((R)-3-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
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C36H49ClN4O3
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1
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1 |
IC50 = 940 nM
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CP0405831
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1-[(R)-2-[((1R,2R)-1-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
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C36H49ClN4O3
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1
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1 |
IC50 = 980 nM
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CP0376348
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ethyl N-[[1-[(2R)-3-(4-chlorophenyl)-2-[[(3R)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]amino]propanoyl]-4-cyclohexylpiperidin-4-yl]methyl]-N-propan-2-ylcarbamate
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C37H51ClN4O4
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1
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1 |
IC50 = 1100 nM
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CP0451850
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(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((4,4-dimethyl-2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C36H47ClN4O4
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1
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1 |
IC50 = 1100 nM
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CP0495900
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(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((2-oxoimidazolidin-1-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C34H44ClN5O3
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1
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1 |
IC50 = 1100 nM
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CP0376413
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(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(5,5-dimethyl-1,1-dioxo-1lambda*6*-isothiazolidin-2-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
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C36H49ClN4O4S
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1
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1 |
IC50 = 1200 nM
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CP0376349
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(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((N-isopropylmethan-2-ylsulfonamido)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C35H49ClN4O4S
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1
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1 |
IC50 = 1300 nM
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CP0432760
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(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(1,1-dioxo-1lambda*6*-isothiazolidin-2-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
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C34H45ClN4O4S
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1
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1 |
IC50 = 1300 nM
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CP0876570
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Ac-Nle4-cyclo(Asp5-Oic6-D-4,4'-Bic7-Pip8-Trp9-Lys10)-NH2
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C59H88N10O9
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1
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1 |
IC50 = 1300 nM
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CP0490759
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1-[2-[((R)-1-Amino-indane-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
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C35H47ClN4O3
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1
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1 |
IC50 = 1400 nM
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CP0376350
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(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-(((R)-4-methyl-2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C35H45ClN4O4
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1
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1 |
IC50 = 1700 nM
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CP0376351
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(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((3-methyl-2-oxoimidazolidin-1-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C35H46ClN5O3
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1
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1 |
IC50 = 1800 nM
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CP0501131
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(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C34H43ClN4O4
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1
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1 |
IC50 = 2000 nM
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CP0149367
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide
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C33H41ClN6O2
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2
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1 |
IC50 = 2063 nM
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2 |
IC50 = 2067 nM
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CP0497207
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(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(6-oxo-7-oxa-5-aza-spiro[3.4]oct-5-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
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C37H47ClN4O4
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1
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1 |
IC50 = 2100 nM
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CP0382075
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(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(5-oxo-6-oxa-4-aza-spiro[2.4]hept-4-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
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C36H45ClN4O4
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1
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1 |
IC50 = 2400 nM
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CP0451849
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(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-(((S)-4-methyl-2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C35H45ClN4O4
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1
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1 |
IC50 = 2400 nM
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CP0876124
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Ac-Nle4-cyclo(Asp5-His6-D-4-Dip-Pro8-Trp9-Lys10)-NH2
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C55H68N12O9
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1
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1 |
IC50 = 2900 nM
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CP0315803
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(3S,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
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C32H50FN5O3
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1
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1 |
IC50 = 5100 nM
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CP0394115
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Ac-Nle4-cyclo(Asp5-His6-D-Nle-Pro8-Trp9-Lys10)-NH2
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C46H66N12O9
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1
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1 |
IC50 > 10000 nM
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CP0394119
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Ac-Nle4-cyclo(Asp5-His6-D-Glu-Pro8-Trp9-Lys10)-NH2
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C45H62N12O11
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1
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1 |
IC50 > 10000 nM
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CP0394120
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Ac-Nle4-cyclo(Asp5-His6-D-Tic-Pro8-Trp9-Lys10)-NH2
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C51H66N12O9
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1
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1 |
IC50 > 10000 nM
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CP0433726
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Ac-Nle4-cyclo(Asp5-His6-D-Gln-Pro8-Trp9-Lys10)-NH2
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C45H63N13O10
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1
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1 |
IC50 > 10000 nM
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CP0434012
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Ac-Nle4-cyclo(Asp5-His6-D-His-Pro8-Trp9-Lys10)-NH2
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C46H62N14O9
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1
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1 |
IC50 > 10000 nM
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CP0434038
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Ac-Nle4-cyclo(Asp5-His6-D-Lys-Pro8-Trp9-Lys10)-NH2
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C46H67N13O9
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1
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1 |
IC50 > 10000 nM
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CP0878527
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Ac-Nle4-cyclo(Asp5-Phg6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
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C58H70N10O9
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1
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1 |
IC50 > 1000 nM
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CP0879920
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Ac-Nle4-cyclo(Asp5-Oic6-D-D-pBzlPhe7-Pip8-Trp9-Lys10)-NH2
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C60H78N10O9
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1
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1 |
IC50 > 1000 nM
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CP0433731
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Ac-Nle4-cyclo(Asp5-His6-L-Tyr(Me)-Pro8-Trp9-Lys10)-NH2
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C50H66N12O10
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1
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1 |
IC50 > 2000 nM
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CP0844894
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Ac-Nle4-cyclo(Asp5-Oic6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
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C59H76N10O9
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1
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1 |
IC50 > 5000 nM
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CP0855016
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Ac-Nle4-cyclo(Asp5-His6-D-4-Thz-Pro8-Trp9-Lys10)-NH2
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C44H60N12O9S
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1
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1 |
IC50 > 5000 nM
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CP0964966
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-5-oxo-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-9,15,32,38-tetrakis(4-aminobutyl)-21-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C144H214N38O30S2
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1
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1 |
Ki = 85.11 nM
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CP0961058
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(S)-1-((S)-1-((6S,9S,15S,18S,21R,24S,27S,30S,33S,36S)-1-((S)-1-((S)-1-((2S,5S,8S,11S,14R,17S,20S,23S,26S)-20-((1H-imidazol-5-yl)methyl)-26-amino-5,11-bis(3-amino-3-oxopropyl)-2,8-bis(4-aminobutyl)-23-benzyl-14-(carbamoylthiomethyl)-17-(4-hydroxybenzyl)-28-methyl-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazanonacosane)pyrrolidine-2-carbonyl)pyrrolidin-2-yl)-24-(3-amino-3-oxopropyl)-9,15,30-tris(4-aminobutyl)-6,18,27-tribenzyl-21-(carbamoylthiomethyl)-36-(3-guanidinopropyl)-33-isobutyl-1,4,7,10,13,16,19,22,25,28,31,34-dodecaoxo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaazaheptatriacontane)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid
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C146H218N40O32S2
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1
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1 |
Ki = 109.65 nM
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CP0961059
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-32,38-bis(4-aminobutyl)-21-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-9,15-bis(2-methylpropyl)-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C144H212N36O30S2
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1
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1 |
Ki = 398.11 nM
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CP0944118
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-32,38-bis(4-aminobutyl)-21-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-9,15-di(propan-2-yl)-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C142H208N36O30S2
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1
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1 |
Ki = 724.44 nM
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CP0944134
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-32,38-bis(4-aminobutyl)-21-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-9,15-bis(hydroxymethyl)-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C138H200N36O32S2
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1
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1 |
Ki = 776.25 nM
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CP0964152
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-32,38-bis(4-aminobutyl)-21-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-9,15-dimethyl-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C138H200N36O30S2
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1
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1 |
Ki = 912.01 nM
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