General Information of the Compound
Compound ID
CP0382832
Compound Name
N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-2-cyclohexylethyl]-N-propan-2-ylpyridazine-3-carboxamide
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Structure
Formula
C35H50F2N6O2
Molecular Weight
624.821
Canonical SMILES
CC(C)N(CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)C(=O)c1cccnn1
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InChI
InChI=1S/C35H50F2N6O2/c1-24(2)43(34(45)31-12-9-15-38-39-31)23-32(25-10-7-6-8-11-25)40-16-18-41(19-17-40)33(44)29-22-42(35(3,4)5)21-28(29)27-14-13-26(36)20-30(27)37/h9,12-15,20,24-25,28-29,32H,6-8,10-11,16-19,21-23H2,1-5H3/t28-,29+,32?/m0/s1
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InChIKey
DOVNDOSDULTCGE-QSVHXPHUSA-N
Physicochemical Property
logP
5.2126
Rotatable Bonds
8
Heavy Atom Count
45
Polar Areas
72.88
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49862375
ChEMBL ID
CHEMBL1209318
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01325, Melanocortin receptor 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 90 nM
   TI
   LI
   LO
   TS
2
IC50 = 770 nM
   TI
   LI
   LO
   TS
Protein ID: PT01804, Melanocortin receptor 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 490 nM
   TI
   LI
   LO
   TS
2
IC50 = 130 nM
   TI
   LI
   LO
   TS
Protein ID: PT00911, Melanocyte-stimulating hormone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 1200 nM
   TI
   LI
   LO
   TS
2
IC50 = 1900 nM
   TI
   LI
   LO
   TS