3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

N-[3-[[5-chloro-2-[4-methoxy-3-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

N-[3-[[5-chloro-2-[4-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

N-[3-[[5-chloro-2-[3-chloro-4-[3-(4-ethylpiperazin-1-yl)propoxy]anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

N-[3-[[5-fluoro-2-[4-methoxy-3-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

N-[3-[[5-chloro-2-[3-chloro-4-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

N-[3-[2-[3-chloro-4-(3-morpholin-4-ylpropoxy)anilino]thieno[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

N-[3-[[5-chloro-2-[4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

N-methyl-N-[(1S,2R,5S)-2-methyl-5-prop-1-en-2-ylcyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-Methyl-N-((5S)-2-methyl-5-(prop-1-en-2-yl)cyclohexyl)-7Hpyrrolo[2,3-d]pyrimidin-4-amine

N-[3-[[5-chloro-2-[3-methoxy-4-(3-morpholin-4-ylpropoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

N-[3-[[5-chloro-2-[3-chloro-4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

US8609647, 52

US8609647, 26

N-[3-[[5-fluoro-2-[3-methoxy-4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

N-benzyl-2-[(2R)-2-[(1S,3S,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl]propoxy]acetamide

2-Methyl-3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

DELGOCITINIB

N-methyl-N-[(3R,4R)-4-methyl-1-(2,2,2-trifluoroethylsulfonyl)piperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HM71224

IBRUTINIB

4-amino-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

4-[[4-(2-methylpyrrolidin-1-yl)-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

3,3,3-trifluoro-1-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]propan-1-one

(R)-2-((1S,3S,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)propan-1-ol

2-cyclopropyl-1-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]ethanone

N-(2,5-dimethylcyclohexyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

US8609647, 19

N-[3-[[5-chloro-2-[3-methoxy-4-(2-morpholin-4-yl-2-oxoethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

SPEBRUTINIB

(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-(3-methyl-1,2-thiazol-5-yl)piperidine-1-carboxamide

3-(4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-piperidine-1-carbonyl)cyclopentanone

2-hydroxy-1-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]ethanone

N,N-diethyl-2-[(2R)-2-[(1S,3S,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl]propoxy]acetamide

N-methyl-2-[(2R)-2-[(1S,3S,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl]propoxy]acetamide

cyclopentyl-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]methanone

(4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-piperidin-1-yl)(tetrahydrofuran-3-yl)methanone

US8609647, 82

N-[(3R,4R)-1-[(2,3-difluorophenyl)methyl]-4-methylpiperidin-3-yl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

4-[[4-[cyclohexyl(methyl)amino]-5-methylpyrimidin-2-yl]amino]benzamide

N-[3-[2-[4-(3-morpholin-4-ylpropylsulfanyl)anilino]thieno[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

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INCB-018424

4-[[4-[(3S)-3-hydroxypyrrolidin-1-yl]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

N-cyclooctyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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N-[3-[[2-[4-(morpholin-4-ylmethyl)anilino]thieno[3,2-d]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

N-(2-ethylcyclohexyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

4-[[4-(3-methylpyrrolidin-1-yl)-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

N-methyl-N-(2-methylcyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

US8609647, 44

4-[[4-[cyclohexyl(methyl)amino]pyrimidin-2-yl]amino]benzoic acid

4-[[4-[cyclohexyl(methyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

N-cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

rac-4-(2-Methylpyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

N-[3-[2-[4-(morpholin-4-ylmethyl)anilino]thieno[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

US8609647, 88

N-[3-[2-[4-(3-morpholin-4-ylpropoxy)anilino]thieno[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

N-[3-[2-[4-(2-morpholin-4-ylethoxy)anilino]thieno[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

N-[3-[[5-chloro-2-[2-methyl-4-[3-(4-methylpiperazin-1-yl)propoxy]anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

rac-4-(3-Methylpyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

N-cycloheptyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

4-[[4-pyrrolidin-1-yl-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

4-[[4-[cyclohexyl(methyl)amino]pyrimidin-2-yl]amino]benzamide

2,2-Dimethyl-3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

1-Benzyl-3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)pyrrolidin-2-one

4-amino-2-[4-(2-cyanopropan-2-yl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide

4-[[4-piperidin-1-yl-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

US8609647, 28

rac-4-(3-Methylpiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

N-methyl-N-(3-methylcyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

rac-4-(2-Methylpiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

(4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-piperidin-1-yl)(thiophen-3-yl)methanone

1-(4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-piperidin-1-yl)-2-(methylsulfonyl)ethanone

(R)-2-((1S,3S,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)propyl Diethylcarbamate

4-(Piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

US8609647, 48

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4-amino-2-(4-tert-butylphenyl)-N-methylthieno[3,2-c]pyridine-7-carboxamide

methyl 1-[2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetyl]pyrrolidine-2-carboxylate

rac-3-(6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-1H-pyrrolo[3,4-b]pyridin-1-yl)-3-oxopropanenitrile

9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3,4,4a,9,9a-hexahydro-1H-carbazole

4-[[4-[cyclohexyl(methyl)amino]pyrimidin-2-yl]amino]-N,N-dimethylbenzamide

2-cyclopentyl-1-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]ethanone

N-(2,2-dimethylcyclohexyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

US8609647, 83

4-pyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine

4-(2,5-Dimethylpyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

US9346810, 7

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide

4-cyclohexyloxy-7H-pyrrolo[2,3-d]pyrimidine;hydrochloride

4-(Octahydro-1H-indol-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

4-amino-N-methyl-2-[4-(trifluoromethoxy)phenyl]thieno[3,2-c]pyridine-7-carboxamide

N-methyl-N-(4-methylcyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-cyclopentyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

rac-N-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl)-2-cyano-N-methylacetamide

[4-[[4-[cyclohexyl(methyl)amino]pyrimidin-2-yl]amino]phenyl]methanol

US8609647, 18

4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-hydroxyethyl)thieno[3,2-c]pyridine-7-carboxamide

(5-chloro-2,3-dihydro-1-benzofuran-2-yl)-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]methanone

methyl 2-[[2-[4-[[5-chloro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]acetyl]amino]acetate

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

N-(2-methoxycyclohexyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

4-amino-N-methyl-2-(4-methylphenyl)thieno[3,2-c]pyridine-7-carboxamide

rac-3-(7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,7-diazaspiro[4.4]nonan-2-yl)-3-oxopropanenitrile

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(3-morpholin-4-ylpropyl)thieno[3,2-c]pyridine-7-carboxamide

rac-N-((1-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-2-yl)methyl)-2-cyano-N-methylacetamide

4-amino-N-methyl-2-phenylthieno[3,2-c]pyridine-7-carboxamide

4-[[4-[cyclohexyl(methyl)amino]-5-ethylpyrimidin-2-yl]amino]benzamide

(E)-N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-piperidin-1-ylbut-2-enamide

N-methyl-N-(2-pentylcyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-morpholin-4-ylethyl)thieno[3,2-c]pyridine-7-carboxamide

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-(1H-pyrazol-4-yl)pyridin-2-amine

4-amino-N-ethyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide

4-(1-cyclohexylethenyl)-7H-pyrrolo[2,3-d]pyrimidine

N-methyl-N-[(1R,5R)-2-methyl-5-prop-1-en-2-ylcyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

rac-3-(5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-3-oxopropanenitrile

(E)-N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)but-2-enamide

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-methoxyethyl)thieno[3,2-c]pyridine-7-carboxamide

4-amino-N-methyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide

3-[1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

4-amino-N,N-dimethyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide

2-methyl-N-[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide

(E)-N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-morpholin-4-ylbut-2-enamide

3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

4-N-cyclohexyl-4-N-methyl-2-N-phenylpyrimidine-2,4-diamine

N-methyl-N-[5-methyl-2-(3-methylbutyl)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

4-(dimethylamino)-N-[2-methyl-3-[1-methyl-5-[4-(morpholine-4-carbonyl)-3-(prop-2-enoylamino)anilino]-6-oxopyridin-3-yl]phenyl]benzamide

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-(2-piperidin-1-ylethyl)thieno[3,2-c]pyridine-7-carboxamide

(E)-N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-enamide

cyclohexyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)methanone

rac-3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-3-oxopropanenitrile

3-[1-(2-chloro-5-fluorophenyl)ethoxy]-5-(3-piperazin-1-ylphenyl)pyridin-2-amine

4-amino-2-(4-morpholin-4-ylphenyl)-N-phenylthieno[3,2-c]pyridine-7-carboxamide

4-[cyclohexyl(methyl)amino]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-[2-(dimethylamino)ethyl]thieno[3,2-c]pyridine-7-carboxamide

9-(1-methylpyrazol-4-yl)-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-one

(E)-N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]pyrido[3,4-d]pyrimidin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide

DACOMITINIB

(E)-N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-7-ethoxyquinazolin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-enamide

rac-4-(1-Cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine hydrochloride

(E)-N-[4-[[1-(benzenesulfonyl)indol-5-yl]amino]-7-ethoxyquinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide

4-N-cyclohexyl-4-N,6-N-dimethylpyrimidine-4,6-diamine

(E)-N-[4-(4-phenoxyanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide

(E)-N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-7-ethoxyquinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]but-2-enamide

(E)-N-[7-methoxy-4-(4-phenoxyanilino)quinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-4-(dimethylamino)but-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide

(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-[di(propan-2-yl)amino]but-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)but-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]pyrido[3,4-d]pyrimidin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-[(2R,6S)-2,6-dimethylpiperidin-1-yl]but-2-enamide

(E)-4-(dimethylamino)-N-[4-(4-phenoxyanilino)pyrido[3,4-d]pyrimidin-6-yl]but-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-[di(propan-2-yl)amino]but-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-(4-methylpiperazin-1-yl)but-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-[(2S,6R)-2,6-dimethylpiperazin-1-yl]but-2-enamide

(E)-N-[4-[(1-benzylindazol-5-yl)amino]-7-ethoxyquinazolin-6-yl]-4-morpholin-4-ylbut-2-enamide

(E)-N-[7-ethoxy-4-[4-(pyridin-2-ylmethoxy)anilino]quinazolin-6-yl]-4-pyrrolidin-1-ylbut-2-enamide

(E)-N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-4-(dimethylamino)but-2-enamide