Brief Information of the Cell Line and Protein
Cell Line ID: CL000265 , NS0
Synonyms
NSO
NS/0
NS/O
Category Cancer cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_3940
Protein ID: PT00842 , 72 kDa type IV collagenase
Gene Name MMP2
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P08253
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000265  Protein ID: PT00842
 
Compound ID Compound Name Compound Formula
CP0081310
N-(2-aminoethyl)-4-[4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]benzenesulfonamide
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C22H24N4O3S2
 1
1
IC50 = 730 nM
   TI
   LI
   LO
   TS
CP0205581
N-[(1R,2S)-2-aminocyclohexyl]-4-[4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]benzenesulfonamide
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C26H30N4O3S2
 1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0117835
5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]-N-[(2R)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]furan-2-carboxamide
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C25H27FN4O4S
 1
1
IC50 = 3100 nM
   TI
   LI
   LO
   TS
CP0081308
N-[(1R,2R)-2-aminocyclohexyl]-4-[4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]benzenesulfonamide
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C26H30N4O3S2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0099232
5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]-N-[(2S)-3-methyl-1-(methylamino)-1-oxobutan-2-yl]furan-2-carboxamide
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C25H27FN4O4S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0159081
N-[(1R)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]-5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]furan-2-carboxamide
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C28H31FN4O4S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0228996
N-(2-hydroxyethyl)-4-[4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]benzenesulfonamide
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C22H23N3O4S2
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0228998
N-[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]-5-[3-fluoro-4-[(4-oxo-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)sulfanylmethyl]phenyl]furan-2-carboxamide
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C28H31FN4O4S
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS