General Information of the Compound
Compound ID
CP0970441
Compound Name
(S)-1-(1-(1-(3,3-difluoropyrrolidin-1-yl)-1-oxopropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
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Structure
Formula
C19H24F2N4O2
Molecular Weight
378.423
Canonical SMILES
C[C@@H](C(=O)N1CCC(F)(F)C1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1
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InChI
InChI=1S/C19H24F2N4O2/c1-13(17(26)24-11-8-19(20,21)12-24)23-9-6-14(7-10-23)25-16-5-3-2-4-15(16)22-18(25)27/h2-5,13-14H,6-12H2,1H3,(H,22,27)/t13-/m0/s1
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InChIKey
UJDNPWHCTGQTER-ZDUSSCGKSA-N
Physicochemical Property
logP
2.2226
Rotatable Bonds
3
Heavy Atom Count
27
Polar Areas
61.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166634226
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01943, Phospholipase D1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 170 nM
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   LI
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Protein ID: PT01153, Phospholipase D2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2900 nM
   TI
   LI
   LO
   TS