General Information of the Protein
Protein ID
PT01153
Protein Name
Phospholipase D2
Secondarily
Protein Name
Choline phosphatase 2
PLD1C
Phosphatidylcholine-hydrolyzing phospholipase D2
Gene Name
PLD2
Sequence
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Hydrolase
Function
Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).
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Uniprot ID
Primary ID:
O14939

Secondarily ID:
I3L2C9
O43540
O43579
O43580
Q6PGR0
Q96BY3
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Ensembl ID
ENSG00000129219
HGNC ID
HGNC:9068
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0521140
 Compound Info 
N-[2-[(4S)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-1H-indole-2-carboxamide
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C25H27FN4O2
  1
1
IC50 = 2.5 nM
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CP0421275
 Compound Info 
N-[(2S)-1-[(4S)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]propan-2-yl]-1H-indole-2-carboxamide
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C26H29FN4O2
  1
1
IC50 = 12 nM
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CP0440703
 Compound Info 
3,4-difluoro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide
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C21H21F3N4O2
  1
1
IC50 = 14 nM
 Bioactivity Info 
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CP0267179
 Compound Info 
N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide
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C26H27FN4O2
  1
1
IC50 = 20 nM
 Bioactivity Info 
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CP0086302
 Compound Info 
4-bromo-N-[(2S)-1-[1-(3-methylphenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
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C24H29BrN4O2
  1
1
IC50 = 20 nM
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CP0507536
 Compound Info 
5-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylidene-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-1H-indole-2-carboxamide;2,2,2-tris(fluoranyl)ethanoic acid
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C24H25F2N5O2
  1
1
IC50 = 25 nM
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CP0575128
 Compound Info 
N-[(2S)-1-[(4S)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]propan-2-yl]naphthalene-2-carboxamide
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C28H30FN3O2
  1
1
IC50 = 26 nM
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CP0503076
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]-1-benzothiophene-2-carboxamide
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C24H26N4O2S
  1
1
IC50 = 30 nM
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CP0384198
 Compound Info 
5-fluoranyl-N-[2-[1-(4-fluorophenyl)-4-oxidanylidene-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-1H-indole-2-carboxamide;2,2,2-tris(fluoranyl)ethanoic acid
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C24H25F2N5O2
  1
1
IC50 = 30 nM
 Bioactivity Info 
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CP0419612
 Compound Info 
4-fluoro-N-[(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
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C23H26F2N4O2
  1
1
IC50 = 35 nM
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CP0489455
 Compound Info 
N-[2-[1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamide
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C25H26FN5O2
  1
1
IC50 = 40 nM
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CP0336940
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]quinoline-3-carboxamide
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C24H25N5O2
  1
1
IC50 = 42 nM
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CP0536743
 Compound Info 
4-chloro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide
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C21H22ClFN4O2
  1
1
IC50 = 42 nM
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CP0533776
 Compound Info 
N-[2-[(4R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-1H-indole-2-carboxamide
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C25H27FN4O2
  1
1
IC50 = 43 nM
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CP0648741
 Compound Info 
4-Hydroxytamoxifen
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C26H29NO2
  1
1
IC50 = 44 nM
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CP0371703
 Compound Info 
N-[2-[1-(4-chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-5-fluoro-1H-indole-2-carboxamide
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C24H25ClFN5O2
  1
1
IC50 = 50 nM
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CP0507935
 Compound Info 
N-[(1S)-2-[1-(3-fluorophenyl)-4-keto-1,3,8-triazaspiro[4.5]decan-8-yl]-1-methyl-ethyl]-2-naphthamide;2,2,2-trifluoroacetic acid
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C27H29FN4O2
  1
1
IC50 = 60 nM
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CP0521139
 Compound Info 
N-[2-[(4S)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamide
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C26H27FN4O2
  1
1
IC50 = 60 nM
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CP0374228
 Compound Info 
4-chloro-N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide
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C21H22ClFN4O2
  1
1
IC50 = 61 nM
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CP0507538
 Compound Info 
N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamide
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C25H26FN5O2
  1
1
IC50 = 63 nM
 Bioactivity Info 
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CP0552839
 Compound Info 
4-fluoro-N-[(2S)-1-[(5R)-5-(3-fluorophenyl)-2-oxo-1-oxa-3,9-diazaspiro[5.5]undecan-9-yl]propan-2-yl]benzamide
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C24H27F2N3O3
  1
1
IC50 = 64 nM
 Bioactivity Info 
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CP0230203
 Compound Info 
ML299 (5)
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C23H26BrFN4O2
  1
1
IC50 = 67 nM
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CP0434813
 Compound Info 
N-[2-[1-(3-chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-4-fluorobenzamide
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C22H24ClFN4O2
  1
1
IC50 = 70 nM
 Bioactivity Info 
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CP0477517
 Compound Info 
N-[2-[1-(3,4-difluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamide
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C25H25F2N5O2
  1
1
IC50 = 70 nM
 Bioactivity Info 
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CP0439922
 Compound Info 
N-[2-[(4S)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-3-phenylprop-2-ynamide
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C25H26FN3O2
  1
1
IC50 = 70 nM
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CP0402137
 Compound Info 
N-[2-[1-(3-chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-5-fluoro-1H-indole-2-carboxamide
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C24H25ClFN5O2
  1
1
IC50 = 73 nM
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CP0374230
 Compound Info 
N-[2-[4-(5-bromo-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide
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C21H22BrFN4O2
  1
1
IC50 = 76 nM
 Bioactivity Info 
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CP0038636
 Compound Info 
3,4,5-Trimethoxy-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 55
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C24H30N4O5
  1
1
IC50 = 79 nM
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CP0477518
 Compound Info 
N-[2-[1-(4-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide
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C26H27FN4O2
  1
1
IC50 = 80 nM
 Bioactivity Info 
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CP0140910
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-2-carboxamide
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C25H27N5O2
  1
1
IC50 = 90 nM
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CP0374231
 Compound Info 
N-[2-[4-(5-bromo-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-chlorobenzamide
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C21H22BrClN4O2
  1
1
IC50 = 97 nM
 Bioactivity Info 
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CP0402135
 Compound Info 
N-[2-[1-(3,4-difluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-5-fluoro-1H-indole-2-carboxamide
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C24H24F3N5O2
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0427790
 Compound Info 
N-[2-[1-(4-bromophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-5-fluoro-1H-indole-2-carboxamide
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C24H25BrFN5O2
  1
1
IC50 = 100 nM
 Bioactivity Info 
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CP0238293
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide
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C26H28N4O2
  1
1
IC50 = 110 nM
 Bioactivity Info 
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CP0519310
 Compound Info 
N-[(2S)-1-[(4S)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]propan-2-yl]quinoline-3-carboxamide
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C27H29FN4O2
  1
1
IC50 = 115 nM
 Bioactivity Info 
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CP0502780
 Compound Info 
N-[2-[1-(3,4-difluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide
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C26H26F2N4O2
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0396587
 Compound Info 
3,4-difluoro-N-[(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
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C23H25F3N4O2
  1
1
IC50 = 120 nM
 Bioactivity Info 
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CP0136326
 Compound Info 
3,4-Difluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 47
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C21H22F2N4O2
  1
1
IC50 = 130 nM
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CP0455920
 Compound Info 
N-[2-[4-(5-fluoro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide
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C25H25FN4O2
  1
1
IC50 = 140 nM
 Bioactivity Info 
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CP0424925
 Compound Info 
N-[(1S)-2-(4-keto-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-1-methyl-ethyl]-2-naphthamide;2,2,2-trifluoroacetic acid
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C27H30N4O2
  1
1
IC50 = 140 nM
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CP0136333
 Compound Info 
4-Chloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 50
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C21H23ClN4O2
  1
1
IC50 = 140 nM
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CP0421274
 Compound Info 
N-[(2S)-1-[(4R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]propan-2-yl]-1H-indole-2-carboxamide
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C26H29FN4O2
  1
1
IC50 = 140 nM
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CP0421276
 Compound Info 
N-[(2S)-1-[(4S)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]propan-2-yl]-3-phenylprop-2-ynamide
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C26H28FN3O2
  1
1
IC50 = 150 nM
 Bioactivity Info 
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CP0477516
 Compound Info 
N-[2-[1-(3-chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamide
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C25H26ClN5O2
  1
1
IC50 = 165 nM
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CP0374236
 Compound Info 
N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-3,4-difluoro-benzamide;2,2,2-trifluoroacetic acid
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C22H23BrF2N4O2
  1
1
IC50 = 187 nM
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CP0424926
 Compound Info 
3,4-bis(fluoranyl)-N-[(2S)-1-(4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
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C23H26F2N4O2
  1
1
IC50 = 200 nM
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CP0415349
 Compound Info 
N-[2-[1-(4-chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamide
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C25H26ClN5O2
  1
1
IC50 = 200 nM
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CP0428098
 Compound Info 
4-bromo-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide
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C22H24BrFN4O2
  1
1
IC50 = 200 nM
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CP0952871
 Compound Info 
1-(1-((S)-1-((3R,5S)-3,5-dimethylpiperazin-1-yl)-1-oxopropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
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C21H31N5O2
  1
1
IC50 = 200 nM
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CP0136331
 Compound Info 
4-Methyl-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 52
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C22H26N4O2
  1
1
IC50 = 210 nM
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CP0144408
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1-benzothiophene-2-carboxamide
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C23H24N4O2S
  1
1
IC50 = 210 nM
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CP0471739
 Compound Info 
4-fluoro-N-[(2S)-1-[(4S)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
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C24H27F2N3O2
  1
1
IC50 = 210 nM
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CP0038644
 Compound Info 
3,4-Dichloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 48
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C21H22Cl2N4O2
  1
1
IC50 = 220 nM
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CP0297516
 Compound Info 
4,5-Dibromo-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)furan-2-carboxamide, 64
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C19H20Br2N4O3
  1
1
IC50 = 220 nM
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CP0470770
 Compound Info 
4-fluoro-N-[2-[(4S)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]ethyl]benzamide
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C23H25F2N3O2
  1
1
IC50 = 220 nM
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CP0952867
 Compound Info 
1-(1-((S)-1-((3R,5R)-3,5-dimethylpiperazin-1-yl)-1-oxopropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
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C21H31N5O2
  1
1
IC50 = 230 nM
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CP0465471
 Compound Info 
N-[2-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-methylbenzamide
   Show/Hide
C22H25ClN4O2
  1
1
IC50 = 240 nM
 Bioactivity Info 
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CP0125380
 Compound Info 
CID25105707
   Show/Hide
C27H27N5O2
  1
1
IC50 = 260 nM
 Bioactivity Info 
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CP0489457
 Compound Info 
N-[2-[1-(3-chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide
   Show/Hide
C26H27ClN4O2
  1
1
IC50 = 290 nM
 Bioactivity Info 
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CP0136322
 Compound Info 
N-[2-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide
   Show/Hide
C21H22ClFN4O2
  2
1
IC50 = 300 nM
 Bioactivity Info 
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2
IC50 = 6500 nM
 Bioactivity Info 
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CP0038642
 Compound Info 
5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide, 14
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C23H24FN5O2
  1
1
IC50 = 300 nM
 Bioactivity Info 
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CP0967343
 Compound Info 
1-(1-((S)-1-((S)-4-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-1-oxopropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
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C25H30N4O2
  1
1
IC50 = 320 nM
 Bioactivity Info 
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CP0240265
 Compound Info 
CID25105709
   Show/Hide
C19H23N5O2
  1
1
IC50 = 340 nM
 Bioactivity Info 
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CP0373641
 Compound Info 
N-[2-[1-(4-bromophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide
   Show/Hide
C26H27BrN4O2
  1
1
IC50 = 350 nM
 Bioactivity Info 
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CP0415353
 Compound Info 
4-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylidene-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
   Show/Hide
C22H24F2N4O2
  2
1
IC50 = 350 nM
 Bioactivity Info 
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2
IC50 = 6700 nM
 Bioactivity Info 
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CP0145932
 Compound Info 
3,4-bis(fluoranyl)-N-[2-[1-(3-fluorophenyl)-4-oxidanylidene-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
   Show/Hide
C22H23F3N4O2
  1
1
IC50 = 355 nM
 Bioactivity Info 
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CP0474556
 Compound Info 
N-[(1S)-2-[4-(6-fluoro-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-2-naphthamide;2,2,2-trifluoroacetic acid
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C26H27FN4O2
  1
1
IC50 = 360 nM
 Bioactivity Info 
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CP0402142
 Compound Info 
N-[2-[1-(4-bromophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]quinoline-3-carboxamide
   Show/Hide
C25H26BrN5O2
  1
1
IC50 = 360 nM
 Bioactivity Info 
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CP0445166
 Compound Info 
4-fluoro-N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide
   Show/Hide
C21H22F2N4O2
  1
1
IC50 = 375 nM
 Bioactivity Info 
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CP0238288
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide
   Show/Hide
C25H26N4O2
  1
1
IC50 = 380 nM
 Bioactivity Info 
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CP0228470
 Compound Info 
CID21428857
   Show/Hide
C19H22N4O3
  1
1
IC50 = 450 nM
 Bioactivity Info 
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CP0468373
 Compound Info 
US9127005, CTH Racemic mixture
   Show/Hide
C26H27FN4O2
  1
1
IC50 = 450 nM
 Bioactivity Info 
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CP0240263
 Compound Info 
4-Fluoro-N-(4-fluorobenzoyl)-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 66
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C28H26F2N4O3
  1
1
IC50 = 470 nM
 Bioactivity Info 
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CP0398751
 Compound Info 
(2S)-N-[2-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2-phenylcyclopropane-1-carboxamide
   Show/Hide
C24H27ClN4O2
  1
1
IC50 = 520 nM
 Bioactivity Info 
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CP0424927
 Compound Info 
4-amino-3-methoxy-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]benzamide;2,2,2-trifluoroacetic acid
   Show/Hide
C23H29N5O3
  1
1
IC50 = 550 nM
 Bioactivity Info 
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CP0507916
 Compound Info 
4-fluoranyl-N-[2-[1-(4-fluorophenyl)-4-oxidanylidene-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
   Show/Hide
C22H24F2N4O2
  1
1
IC50 = 610 nM
 Bioactivity Info 
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CP0523868
 Compound Info 
N-[2-[1-(4-chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide
   Show/Hide
C26H27ClN4O2
  1
1
IC50 = 655 nM
 Bioactivity Info 
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CP0502781
 Compound Info 
N-[2-[1-(3,4-difluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-4-fluorobenzamide
   Show/Hide
C22H23F3N4O2
  1
1
IC50 = 660 nM
 Bioactivity Info 
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CP0468781
 Compound Info 
US9127005, P0L
   Show/Hide
C27H29FN4O2
  1
1
IC50 = 700 nM
 Bioactivity Info 
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CP0474557
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-3-phenylprop-2-ynamide
   Show/Hide
C23H24N4O2
  1
1
IC50 = 730 nM
 Bioactivity Info 
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CP0474558
 Compound Info 
N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-3,4-difluoro-benzamide;2,2,2-trifluoroacetic acid
   Show/Hide
C22H23ClF2N4O2
  1
1
IC50 = 730 nM
 Bioactivity Info 
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CP0374229
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]quinoline-6-carboxamide
   Show/Hide
C24H25N5O2
  1
1
IC50 = 740 nM
 Bioactivity Info 
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CP0434228
 Compound Info 
4-bromo-N-[(2R)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
   Show/Hide
C23H26BrFN4O2
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0471740
 Compound Info 
N-[2-[(4R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-3-phenylprop-2-ynamide
   Show/Hide
C25H26FN3O2
  1
1
IC50 = 810 nM
 Bioactivity Info 
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CP0517516
 Compound Info 
6-fluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-naphthamide
   Show/Hide
C25H25FN4O2
  1
1
IC50 = 850 nM
 Bioactivity Info 
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CP0374232
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1,4-dihydronaphthalene-2-carboxamide
   Show/Hide
C25H28N4O2
  1
1
IC50 = 860 nM
 Bioactivity Info 
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CP0398753
 Compound Info 
N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-4-chloro-benzamide;2,2,2-trifluoroacetic acid
   Show/Hide
C22H24BrClN4O2
  1
1
IC50 = 890 nM
 Bioactivity Info 
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CP0966189
 Compound Info 
1-(1-((S)-1-((S)-3-ethylpiperazin-1-yl)-1-oxopropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
   Show/Hide
C21H31N5O2
  1
1
IC50 = 920 nM
 Bioactivity Info 
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CP0228146
 Compound Info 
(S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide, 69
   Show/Hide
C26H27ClN4O2
  2
1
IC50 = 933 nM
 Bioactivity Info 
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2
IC50 = 1800 nM
 Bioactivity Info 
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CP0517406
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
   Show/Hide
C26H32N4O2
  1
1
IC50 = 990 nM
 Bioactivity Info 
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CP0228121
 Compound Info 
9-Oxo-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-9H-fluorene-4-carboxamide, 57
   Show/Hide
C28H26N4O3
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0546336
 Compound Info 
4-fluoro-N-[(2S)-1-(7-fluoro-2-oxospiro[1H-3,1-benzoxazine-4,4'-piperidine]-1'-yl)propan-2-yl]benzamide
   Show/Hide
C22H23F2N3O3
  1
1
IC50 = 1000 nM
 Bioactivity Info 
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CP0423544
 Compound Info 
4-chloranyl-N-[(2S)-1-[4-(5-fluoranyl-2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
   Show/Hide
C22H24ClFN4O2
  1
1
IC50 = 1040 nM
 Bioactivity Info 
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CP0396586
 Compound Info 
4-fluoro-N-[(2R)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
   Show/Hide
C23H26F2N4O2
  1
1
IC50 = 1060 nM
 Bioactivity Info 
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CP0268921
 Compound Info 
3,5-Dichloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 49
   Show/Hide
C21H22Cl2N4O2
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0293764
 Compound Info 
4-Methoxy-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 51
   Show/Hide
C22H26N4O3
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0955161
 Compound Info 
1-(1-((S)-1-((S)-3-methylpiperazin-1-yl)-1-oxopropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
   Show/Hide
C20H29N5O2
  1
1
IC50 = 1100 nM
 Bioactivity Info 
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CP0398754
 Compound Info 
(1R,2R)-N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-2-phenyl-cyclopropanecarboxamide;2,2,2-trifluoroacetic acid
   Show/Hide
C25H29ClN4O2
  1
1
IC50 = 1150 nM
 Bioactivity Info 
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CP0522711
 Compound Info 
4-chloranyl-N-[(2S)-1-[4-(5-chloranyl-2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
   Show/Hide
C22H24Cl2N4O2
  1
1
IC50 = 1200 nM
 Bioactivity Info 
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CP0234018
 Compound Info 
4-Chloro-N-(4-chlorobenzoyl)-N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamide, 82
   Show/Hide
C29H28Cl2N4O3
  1
1
IC50 = 1200 nM
 Bioactivity Info 
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CP0549941
 Compound Info 
4-fluoro-N-[(2S)-1-(2-oxospiro[1H-3,1-benzoxazine-4,4'-piperidine]-1'-yl)propan-2-yl]benzamide
   Show/Hide
C22H24FN3O3
  1
1
IC50 = 1300 nM
 Bioactivity Info 
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CP0398762
 Compound Info 
N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-4-fluoro-benzamide;2,2,2-trifluoroacetic acid
   Show/Hide
C22H24ClFN4O2
  1
1
IC50 = 1400 nM
 Bioactivity Info 
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CP0038649
 Compound Info 
CID25105702
   Show/Hide
C23H26N4O2
  1
1
IC50 = 1400 nM
 Bioactivity Info 
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CP0452544
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]-3-phenylprop-2-ynamide
   Show/Hide
C24H26N4O2
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0451901
 Compound Info 
US9127005, NGH
   Show/Hide
C24H27F2N3O2
  1
1
IC50 = 2800 nM
 Bioactivity Info 
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CP0970441
 Compound Info 
(S)-1-(1-(1-(3,3-difluoropyrrolidin-1-yl)-1-oxopropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
   Show/Hide
C19H24F2N4O2
  1
1
IC50 = 2900 nM
 Bioactivity Info 
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CP0462590
 Compound Info 
4-fluoranyl-N-[(2S)-1-[4-(5-fluoranyl-2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
   Show/Hide
C22H24F2N4O2
  1
1
IC50 = 3100 nM
 Bioactivity Info 
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CP0519245
 Compound Info 
US9127005, NFW
   Show/Hide
C23H25F2N3O2
  1
1
IC50 = 3175 nM
 Bioactivity Info 
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CP0575752
 Compound Info 
4-fluoro-N-[(2S)-1-(2-oxospiro[1H-pyrido[4,3-d][1,3]oxazine-4,4'-piperidine]-1'-yl)propan-2-yl]benzamide
   Show/Hide
C21H23FN4O3
  1
1
IC50 = 3200 nM
 Bioactivity Info 
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CP0419613
 Compound Info 
3,4-difluoro-N-[(2R)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
   Show/Hide
C23H25F3N4O2
  1
1
IC50 = 3450 nM
 Bioactivity Info 
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CP0474561
 Compound Info 
(1R,2R)-N-[(1S)-2-[4-(6-fluoro-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-2-phenyl-cyclopropanecarboxamide;2,2,2-trifluoroacetic acid
   Show/Hide
C25H29FN4O2
  1
1
IC50 = 3800 nM
 Bioactivity Info 
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CP0234014
 Compound Info 
(1R,2R)-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-phenylcyclopropanecarboxamide, 58
   Show/Hide
C24H28N4O2
  1
1
IC50 = 3900 nM
 Bioactivity Info 
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CP0398756
 Compound Info 
N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-2-naphthamide;2,2,2-trifluoroacetic acid
   Show/Hide
C26H27BrN4O2
  1
1
IC50 = 3900 nM
 Bioactivity Info 
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CP0557314
 Compound Info 
N-[(2S)-1-[(4R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]propan-2-yl]-3-phenylprop-2-ynamide
   Show/Hide
C26H28FN3O2
  1
1
IC50 = 4000 nM
 Bioactivity Info 
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CP0579185
 Compound Info 
4-fluoro-N-[(2S)-1-(2-oxospiro[1H-pyrido[3,2-d][1,3]oxazine-4,4'-piperidine]-1'-yl)propan-2-yl]benzamide
   Show/Hide
C21H23FN4O3
  1
1
IC50 = 4100 nM
 Bioactivity Info 
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CP0970561
 Compound Info 
(S)-4-fluoro-N-(1-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)benzamide
   Show/Hide
C22H25FN4O2
  1
1
IC50 = 5600 nM
 Bioactivity Info 
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CP0497216
 Compound Info 
N-[2-[1-(4-chlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-4-fluorobenzamide
   Show/Hide
C22H24ClFN4O2
  1
1
IC50 = 5670 nM
 Bioactivity Info 
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CP0143509
 Compound Info 
(1R,2R)-N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-2-phenyl-cyclopropanecarboxamide;2,2,2-trifluoroacetic acid
   Show/Hide
C25H29BrN4O2
  1
1
IC50 = 6400 nM
 Bioactivity Info 
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CP0967342
 Compound Info 
(S)-1-(1-(1-(3,3-dimethylpiperazin-1-yl)-1-oxopropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
   Show/Hide
C21H31N5O2
  1
1
IC50 = 7000 nM
 Bioactivity Info 
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CP0427789
 Compound Info 
N-[2-[1-(4-bromophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]-4-fluorobenzamide
   Show/Hide
C22H24BrFN4O2
  1
1
IC50 = 8000 nM
 Bioactivity Info 
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CP0526191
 Compound Info 
4-fluoranyl-N-[(2S)-1-[4-(4-fluoranyl-2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
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C22H24F2N4O2
  1
1
IC50 = 10000 nM
 Bioactivity Info 
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CP0041761
 Compound Info 
2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol
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C28H27NO4S
  1
1
IC50 = 10000 nM
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CP0544571
 Compound Info 
4-fluoro-N-[(2S)-1-(3-methyl-2-oxospiro[1H-quinazoline-4,4'-piperidine]-1'-yl)propan-2-yl]benzamide
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C23H27FN4O2
  1
1
IC50 > 10000 nM
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CP0546316
 Compound Info 
4-fluoro-N-[(2S)-1-[4-(2-oxoimidazolidin-1-yl)piperidin-1-yl]propan-2-yl]benzamide
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C18H25FN4O2
  1
1
IC50 > 10000 nM
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CP0546335
 Compound Info 
4-fluoro-N-[(2S)-1-[4-(2-oxo-1,3-benzoxazol-3-yl)piperidin-1-yl]propan-2-yl]benzamide
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C22H24FN3O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0546337
 Compound Info 
4-fluoro-N-[(2S)-1-(2-oxospiro[1,3-dihydroquinazoline-4,4'-piperidine]-1'-yl)propan-2-yl]benzamide
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C22H25FN4O2
  1
1
IC50 > 10000 nM
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CP0546338
 Compound Info 
N-[2-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-N-methylacetamide
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C17H23ClN4O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0546341
 Compound Info 
3-[1-[2-(2-oxopyridin-1-yl)ethyl]piperidin-4-yl]-1H-benzimidazol-2-one
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C19H22N4O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0546342
 Compound Info 
4-fluoro-N-[(2S)-1-(2-oxospiro[1,3-dihydroquinoline-4,4'-piperidine]-1'-yl)propan-2-yl]benzamide
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C23H26FN3O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0571524
 Compound Info 
4-fluoro-N-[(2S)-1-[4-(2-oxo-3H-indol-1-yl)piperidin-1-yl]propan-2-yl]benzamide
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C23H26FN3O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0951384
 Compound Info 
(S)-1-(1-(2-(2-oxopyridin-1(2H)-yl)propyl)piperidin-4-yl)-1,3-dihydro-2Hbenzo[d]imidazol-2-one
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C20H24N4O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0952866
 Compound Info 
(S)-1-(1-(1-morpholino-1-oxopropan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
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C19H26N4O3
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0952870
 Compound Info 
(S)-N-(1-(4-(1H-indazol-3-yl)piperidin-1-yl)propan-2-yl)-4-fluorobenzamide
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C22H25FN4O
  1
1
IC50 > 10000 nM
 Bioactivity Info 
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CP0423545
 Compound Info 
4-chloranyl-N-[(2S)-1-[4-(4-fluoranyl-2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
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C22H24ClFN4O2
  1
1
IC50 = 12000 nM
 Bioactivity Info 
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CP0374233
 Compound Info 
N-[(1S)-2-[4-(4-fluoro-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-2-naphthamide;2,2,2-trifluoroacetic acid
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C26H27FN4O2
  1
1
IC50 = 13000 nM
 Bioactivity Info 
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CP0374227
 Compound Info 
3,4-bis(fluoranyl)-N-[(2S)-1-[4-(4-fluoranyl-2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
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C22H23F3N4O2
  1
1
IC50 = 14000 nM
 Bioactivity Info 
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CP0493781
 Compound Info 
(1R,2R)-N-[(1S)-2-[4-(4-fluoro-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-2-phenyl-cyclopropanecarboxamide;2,2,2-trifluoroacetic acid
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C25H29FN4O2
  1
1
IC50 > 20000 nM
 Bioactivity Info 
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CP0422300
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoxaline-2-carboxamide
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C24H26N6O2
  1
1
IC50 > 20000 nM
 Bioactivity Info 
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CP0435029
 Compound Info 
(trans)-N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-phenylcyclopropanecarboxamide
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C25H30N4O2
  1
1
IC50 > 20000 nM
 Bioactivity Info 
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CP0216108
 Compound Info 
CID25105708
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C22H26N4O2S
  1
1
IC50 > 20000 nM
 Bioactivity Info 
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CP0238366
 Compound Info 
2-Chloro-N-(2-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 68
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C21H22Cl2N4O2
  1
1
IC50 > 20000 nM
 Bioactivity Info 
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CP0526629
 Compound Info 
3-methyl-N-[(2S)-1-(4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
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C24H30N4O2
  1
1
IC50 = 27000 nM
 Bioactivity Info 
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CP0452545
 Compound Info 
(trans)-N-((S)-1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propan-2-yl)-2-phenylcyclopropanecarboxamide
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C26H32N4O2
  1
1
IC50 = 30000 nM
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CP0038641
 Compound Info 
CID25105696
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C22H34N4O2
  1
1
IC50 > 2000 nM
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Biochemical Assays
Compound ID Compound Name Compound Formula
CP0038642
 Compound Info 
5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide, 14
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C23H24FN5O2
  2
1 IC50 = 17 nM
2 IC50 = 20 nM
CP0230203
 Compound Info 
ML299 (5)
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C23H26BrFN4O2
  1
1 IC50 = 20 nM
CP0267179
 Compound Info 
N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide
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C26H27FN4O2
  1
1 IC50 = 20 nM
CP0086302
 Compound Info 
4-bromo-N-[(2S)-1-[1-(3-methylphenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide
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C24H29BrN4O2
  1
1 IC50 = 84 nM
CP0252534
 Compound Info 
US9453017, 1
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C26H27FN4O2
  1
1 IC50 = 100 nM
CP0136333
 Compound Info 
4-Chloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 50
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C21H23ClN4O2
  1
1 IC50 = 130 nM
CP0238293
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide
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C26H28N4O2
  1
1 IC50 = 140 nM
CP0297516
 Compound Info 
4,5-Dibromo-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)furan-2-carboxamide, 64
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C19H20Br2N4O3
  1
1 IC50 = 170 nM
CP0238288
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]naphthalene-2-carboxamide
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C25H26N4O2
  1
1 IC50 = 240 nM
CP0038644
 Compound Info 
3,4-Dichloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 48
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C21H22Cl2N4O2
  1
1 IC50 = 250 nM
CP0136322
 Compound Info 
N-[2-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-4-fluorobenzamide
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C21H22ClFN4O2
  3
1 IC50 = 300 nM
2 IC50 = 310 nM
3 IC50 = 1500 nM
CP0144408
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1-benzothiophene-2-carboxamide
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C23H24N4O2S
  2
1 IC50 = 340 nM
2 IC50 = 2000 nM
CP0145932
 Compound Info 
3,4-bis(fluoranyl)-N-[2-[1-(3-fluorophenyl)-4-oxidanylidene-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide;2,2,2-tris(fluoranyl)ethanoic acid
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C22H23F3N4O2
  1
1 IC50 = 355 nM
CP0140910
 Compound Info 
N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-2-carboxamide
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C25H27N5O2
  1
1 IC50 = 500 nM
CP0136326
 Compound Info 
3,4-Difluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 47
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C21H22F2N4O2
  1
1 IC50 = 560 nM
CP0336940
 Compound Info 
N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]quinoline-3-carboxamide
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C24H25N5O2
  1
1 IC50 = 600 nM
CP0228121
 Compound Info 
9-Oxo-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-9H-fluorene-4-carboxamide, 57
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C28H26N4O3
  1
1 IC50 = 600 nM
CP0038636
 Compound Info 
3,4,5-Trimethoxy-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 55
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C24H30N4O5
  1
1 IC50 = 690 nM
CP0228146
 Compound Info 
(S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide, 69
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C26H27ClN4O2
  1
1 IC50 = 933 nM
CP0125380
 Compound Info 
CID25105707
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C27H27N5O2
  1
1 IC50 = 1000 nM
CP0136331
 Compound Info 
4-Methyl-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 52
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C22H26N4O2
  1
1 IC50 = 1100 nM
CP0070013
 Compound Info 
US9453017, 2
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C25H29BrN4O2
  1
1 IC50 = 1100 nM
CP0240265
 Compound Info 
CID25105709
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C19H23N5O2
  1
1 IC50 = 1200 nM
CP0228470
 Compound Info 
CID21428857
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C19H22N4O3
  1
1 IC50 = 1400 nM
CP0038649
 Compound Info 
CID25105702
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C23H26N4O2
  1
1 IC50 = 1900 nM
CP0268921
 Compound Info 
3,5-Dichloro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 49
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C21H22Cl2N4O2
  1
1 IC50 = 1900 nM
CP0240263
 Compound Info 
4-Fluoro-N-(4-fluorobenzoyl)-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 66
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C28H26F2N4O3
  1
1 IC50 = 2200 nM
CP0234018
 Compound Info 
4-Chloro-N-(4-chlorobenzoyl)-N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamide, 82
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C29H28Cl2N4O3
  1
1 IC50 = 2500 nM
CP0041761
 Compound Info 
2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol
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C28H27NO4S
  1
1 IC50 = 3400 nM
CP0143509
 Compound Info 
(1R,2R)-N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-2-phenyl-cyclopropanecarboxamide;2,2,2-trifluoroacetic acid
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C25H29BrN4O2
  1
1 IC50 = 6400 nM
CP0234014
 Compound Info 
(1R,2R)-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-phenylcyclopropanecarboxamide, 58
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C24H28N4O2
  1
1 IC50 = 6800 nM
CP0238366
 Compound Info 
2-Chloro-N-(2-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 68
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C21H22Cl2N4O2
  1
1 IC50 = 12000 nM
CP0648741
 Compound Info 
4-Hydroxytamoxifen
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C26H29NO2
  1
1 IC50 = 74000 nM
CP0216108
 Compound Info 
CID25105708
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C22H26N4O2S
  1
1 IC50 > 20000 nM
CP0293764
 Compound Info 
4-Methoxy-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzamide, 51
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C22H26N4O3
  1
1 IC50 > 20000 nM
Clinical Information about the Protein
Target 1 ( Phospholipase D2 (PLD2) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Coagulation defect [ICD-11: 3B10.0]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 VU0364739
 Drug Info 
Clinical trial
Coagulation defect