General Information of the Compound
Compound ID
CP0964602
Compound Name
3-{1-[5-(3-{[Glycyl(methyl)amino]methyl}phenyl)pyrimidin-2-yl]piperidin-4-yl}propanoic acid dihydrochloride
    Show/Hide
Structure
Formula
C22H31Cl2N5O3
Molecular Weight
484.428
Canonical SMILES
CN(Cc1cccc(-c2cnc(N3CCC(CCC(=O)O)CC3)nc2)c1)C(=O)CN.Cl.Cl
    Show/Hide
InChI
InChI=1S/C22H29N5O3.2ClH/c1-26(20(28)12-23)15-17-3-2-4-18(11-17)19-13-24-22(25-14-19)27-9-7-16(8-10-27)5-6-21(29)30;;/h2-4,11,13-14,16H,5-10,12,15,23H2,1H3,(H,29,30);2*1H
    Show/Hide
InChIKey
AYJFSPGUOGHHRG-UHFFFAOYSA-N
Physicochemical Property
logP
2.9855
Rotatable Bonds
8
Heavy Atom Count
32
Polar Areas
112.65
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 137660775
ChEMBL ID
CHEMBL4101409
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02562, Membrane primary amine oxidase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS