General Information of the Compound
Compound ID
CP0962781
Compound Name
4-cyano-N-{2-[7-(4-cyano-2-fluorobenzyl)-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl]ethyl}benzenesulfonamide
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Structure
Formula
C23H24FN5O3S
Molecular Weight
469.542
Canonical SMILES
N#Cc1ccc(S(=O)(=O)NCCN2CC3CN(Cc4ccc(C#N)cc4F)CC(C2)O3)cc1
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InChI
InChI=1S/C23H24FN5O3S/c24-23-9-18(11-26)1-4-19(23)12-29-15-20-13-28(14-21(16-29)32-20)8-7-27-33(30,31)22-5-2-17(10-25)3-6-22/h1-6,9,20-21,27H,7-8,12-16H2
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InChIKey
NTIZTSVZHGRPHD-UHFFFAOYSA-N
Physicochemical Property
logP
1.43256
Rotatable Bonds
7
Heavy Atom Count
33
Polar Areas
109.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 68521062
ChEMBL ID
CHEMBL3960009
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 < 31622.78 nM
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