General Information of the Compound
Compound ID
CP0959438
Compound Name
(S)-2-((6-(2-(Methoxy-d3)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-phenylethan-1-ol
    Show/Hide
Formula
C21H20N4O2
Molecular Weight
363.4353053
Canonical SMILES
[2H]C([2H])([2H])Oc1ccccc1-c1cc2c(N[C@H](CO)c3ccccc3)ncnc2[nH]1
    Show/Hide
InChI
InChI=1S/C21H20N4O2/c1-27-19-10-6-5-9-15(19)17-11-16-20(24-17)22-13-23-21(16)25-18(12-26)14-7-3-2-4-8-14/h2-11,13,18,26H,12H2,1H3,(H2,22,23,24,25)/t18-/m1/s1/i1D3
    Show/Hide
InChIKey
HXSDKMUJXCRATG-HLENTGRASA-N
Physicochemical Property
logP
3.779
Rotatable Bonds
7
Heavy Atom Count
27
Polar Areas
83.06
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
ChEMBL ID
CHEMBL4793053
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS