General Information of the Compound
Compound ID
CP0956824
Compound Name
(3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(3S,6S,9S,12S)-3-benzyl-6-(carboxymethyl)-12-(1H-indol-3-ylmethyl)-9-[2-(methylsulfanyl)ethyl]-2,5,8,11,14,18-hexaoxo-1,4,7,10,13,17-hexaazacycloicosan-15-yl]carbamoyl}-3-(methylsulfanyl)propyl]carbamoyl}-2-[4-(sulfooxy)phenyl]ethyl]carbamoyl}propanoic acid
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Structure
Formula
C53H67N11O17S3
Molecular Weight
1226.38
Canonical SMILES
CSCC[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc2ccc(OS(=O)(=O)O)cc2)NC(=O)[C@@H](N)CC(=O)O)CNC(=O)CCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC1=O
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InChI
InChI=1S/C53H67N11O17S3/c1-82-20-17-36-48(72)63-41(26-45(68)69)52(76)61-38(22-29-8-4-3-5-9-29)47(71)55-19-16-43(65)57-28-42(53(77)62-40(51(75)59-36)24-31-27-56-35-11-7-6-10-33(31)35)64-49(73)37(18-21-83-2)58-50(74)39(60-46(70)34(54)25-44(66)67)23-30-12-14-32(15-13-30)81-84(78,79)80/h3-15,27,34,36-42,56H,16-26,28,54H2,1-2H3,(H,55,71)(H,57,65)(H,58,74)(H,59,75)(H,60,70)(H,61,76)(H,62,77)(H,63,72)(H,64,73)(H,66,67)(H,68,69)(H,78,79,80)/t34-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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InChIKey
KCJMELOJLDXZPW-IGHJTHJISA-N
Physicochemical Property
logP
-1.81
Rotatable Bonds
24
Heavy Atom Count
84
Polar Areas
441.91
Hydrogen Bond Donor Count
14
Hydrogen Bond Acceptor Count
17
Complexity
84

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73350236
ChEMBL ID
CHEMBL2372076
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00958, Cholecystokinin receptor type A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431 Homo sapiens (Human)  1
1
IC50 = 26660 nM
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