General Information of the Compound
Compound ID
CP0946461
Compound Name
3-(4-(methylsulfinyl)phenyl)-N-(1-(methylsulfonyl)piperidin-4-yl)imidazo[1,2-b]pyridazin-6-amine
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Structure
Formula
C19H23N5O3S2
Molecular Weight
433.559
Canonical SMILES
C[S+]([O-])c1ccc(-c2cnc3ccc(NC4CCN(S(C)(=O)=O)CC4)nn23)cc1
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InChI
InChI=1S/C19H23N5O3S2/c1-28(25)16-5-3-14(4-6-16)17-13-20-19-8-7-18(22-24(17)19)21-15-9-11-23(12-10-15)29(2,26)27/h3-8,13,15H,9-12H2,1-2H3,(H,21,22)
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InChIKey
PPOBKVGXDVRWRX-UHFFFAOYSA-N
Physicochemical Property
logP
1.9696
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
102.66
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155518069
ChEMBL ID
CHEMBL4445827
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 25900 nM
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