General Information of the Compound
Compound ID
CP0937332
Compound Name
SID56463670
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Synonyms
2FL3530AF2
53308-83-1
CAS-53308-83-1
DSSTox_CID_25780
DSSTox_GSID_45780
DSSTox_RID_81122
L-NMMA acetate
N-omega-Monomethyl-L-arginine monoacetate, 99%
SMR000449329
Tilarginine acetate
UNII-2FL3530AF2
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Structure
Formula
C9H20N4O4
Molecular Weight
248.283
Canonical SMILES
CC(=O)O.CNC(=N)NCCC[C@H](N)C(=O)O
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InChI
InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
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InChIKey
IKPNWIGTWUZCKM-JEDNCBNOSA-N
CAS
53308-83-1
Physicochemical Property
logP
-0.98683
Rotatable Bonds
5
Heavy Atom Count
17
Polar Areas
148.53
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
4
Complexity
17

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 135242
SID: 17171942
ChEMBL ID
CHEMBL1256175
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
Potency ~ 4.6 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Tilarginine acetate )
Drug Name Tilarginine acetate
Company ArgiNOx
Indication
Myocardial infarction
Phase 3
Angina pectoris
Discontinued in Phase 2
Target(s)
Nitric-oxide synthase endothelial (NOS3)
Modulator