General Information of the Compound
Compound ID
CP0912856
Compound Name
(+)-(R)-4-Methoxy-N-(7-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-2-yl)benzenesulfonamide
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Structure
Formula
C32H42N4O3S
Molecular Weight
562.78
Canonical SMILES
CCCN(CCN1CCN(c2ccccc2)CC1)[C@@H]1CCc2ccc(NS(=O)(=O)c3ccc(OC)cc3)cc2C1
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InChI
InChI=1S/C32H42N4O3S/c1-3-17-35(21-18-34-19-22-36(23-20-34)29-7-5-4-6-8-29)30-12-10-26-9-11-28(24-27(26)25-30)33-40(37,38)32-15-13-31(39-2)14-16-32/h4-9,11,13-16,24,30,33H,3,10,12,17-23,25H2,1-2H3/t30-/m1/s1
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InChIKey
NFQNUWPIIZWIKT-SSEXGKCCSA-N
Physicochemical Property
logP
4.8875
Rotatable Bonds
11
Heavy Atom Count
40
Polar Areas
65.12
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71660252
ChEMBL ID
CHEMBL2387632
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00957, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 101 nM
   TI
   LI
   LO
   TS
Protein ID: PT01366, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 2.32 nM
   TI
   LI
   LO
   TS