General Information of the Compound
Compound ID
CP0892041
Compound Name
(S)-5-(2-((S)-1-((S)-1-((S)-1-((S)-1-(3-amino-1-((S)-1-((S)-1-((S)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-ylamino)-3-carboxy-1-oxopropan-2-ylamino)-4-(methylthio)-1-oxobutan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-4-(methylthio)-1-oxobutan-2-ylamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)-3-carboxy-1-oxopropan-2-ylamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)-2-oxoethylamino)-4-(bis(2-(bis(2-carboxyethyl)amino)ethyl)amino)-5-oxopentanoic acid
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Structure
Formula
C82H110N16O27S2
Molecular Weight
1816.001
Canonical SMILES
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCC(=O)O)N(CCN(CCC(=O)O)CCC(=O)O)CCN(CCC(=O)O)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
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InChI
InChI=1S/C82H110N16O27S2/c1-126-36-26-55(74(117)93-61(42-71(112)113)79(122)90-57(73(84)116)38-47-8-4-3-5-9-47)89-78(121)60(41-50-45-85-54-11-7-6-10-53(50)54)92-81(124)63(44-83)95-75(118)56(27-37-127-2)88-77(120)59(40-49-14-18-52(100)19-15-49)91-80(123)62(43-72(114)115)94-76(119)58(39-48-12-16-51(99)17-13-48)87-65(101)46-86-82(125)64(20-21-66(102)103)98(34-32-96(28-22-67(104)105)29-23-68(106)107)35-33-97(30-24-69(108)109)31-25-70(110)111/h3-19,45,55-64,85,99-100H,20-44,46,83H2,1-2H3,(H2,84,116)(H,86,125)(H,87,101)(H,88,120)(H,89,121)(H,90,122)(H,91,123)(H,92,124)(H,93,117)(H,94,119)(H,95,118)(H,102,103)(H,104,105)(H,106,107)(H,108,109)(H,110,111)(H,112,113)(H,114,115)/t55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1
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InChIKey
KPZUEGTZVHPLBW-ZCWJDUOTSA-N
Physicochemical Property
logP
-2.7331
Rotatable Bonds
62
Heavy Atom Count
127
Polar Areas
687.18
Hydrogen Bond Donor Count
22
Hydrogen Bond Acceptor Count
26
Complexity
127

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73348650
ChEMBL ID
CHEMBL2372072
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00958, Cholecystokinin receptor type A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431 Homo sapiens (Human)  1
1
IC50 = 32 nM
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