General Information of the Compound
Compound ID
CP0879663
Compound Name
7-(5-methyl-3-isoxazolyl)-3-[3-({4-methyl-5-[3-(methyloxy)-phenyl]-4H-1,2,4-triazol-3-yl}thio)propyl]-2,3,4,5-tetrahydro-1H-3-benzazepine
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Structure
Formula
C27H31N5O2S
Molecular Weight
489.645
Canonical SMILES
COc1cccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)c1
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InChI
InChI=1S/C27H31N5O2S/c1-19-16-25(30-34-19)22-9-8-20-10-13-32(14-11-21(20)17-22)12-5-15-35-27-29-28-26(31(27)2)23-6-4-7-24(18-23)33-3/h4,6-9,16-18H,5,10-15H2,1-3H3
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InChIKey
CNYTYKJCKVUZFG-UHFFFAOYSA-N
Physicochemical Property
logP
5.03712
Rotatable Bonds
8
Heavy Atom Count
35
Polar Areas
69.21
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 23631173
SID: 46492668
ChEMBL ID
CHEMBL242599
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 7.943 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.7943 nM
   TI
   LI
   LO
   TS