General Information of the Compound
Compound ID
CP0877531
Compound Name
(S)-N1-((S)-1-(benzylamino)-1-oxo-4-phenylbutan-2-yl)-2-(4-tert-butylbenzamido)-N4-neopentylsuccinamide
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Structure
Formula
C37H48N4O4
Molecular Weight
612.815
Canonical SMILES
CC(C)(C)CNC(=O)C[C@H](NC(=O)c1ccc(C(C)(C)C)cc1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1
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InChI
InChI=1S/C37H48N4O4/c1-36(2,3)25-39-32(42)23-31(41-33(43)28-18-20-29(21-19-28)37(4,5)6)35(45)40-30(22-17-26-13-9-7-10-14-26)34(44)38-24-27-15-11-8-12-16-27/h7-16,18-21,30-31H,17,22-25H2,1-6H3,(H,38,44)(H,39,42)(H,40,45)(H,41,43)/t30-,31-/m0/s1
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InChIKey
YGZKGBLXMRRKPI-CONSDPRKSA-N
Physicochemical Property
logP
5.0689
Rotatable Bonds
13
Heavy Atom Count
45
Polar Areas
116.4
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90665959
ChEMBL ID
CHEMBL3218825
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02585, Proteasome subunit beta type-5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000187 Calu-6 Homo sapiens (Human)  1
1
IC50 = 40 nM
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