General Information of the Compound
Compound ID
CP0875457
Compound Name
Sub[-Tyr-Arg-Leu-Arg-Tyr-NH2]2
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Synonyms
Sub[-Tyr-Arg-Leu-Arg-Tyr-NH2]2
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Structure
Formula
C80H122N24O18
Molecular Weight
1708.006
Canonical SMILES
CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
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InChI
InChI=1S/C80H122N24O18/c1-43(2)37-59(71(115)95-57(15-9-35-93-79(87)88)69(113)103-63(75(119)120)41-47-21-29-51(107)30-22-47)101-67(111)55(13-7-33-91-77(83)84)97-73(117)61(39-45-17-25-49(105)26-18-45)99-65(109)53(81)11-5-6-12-54(82)66(110)100-62(40-46-19-27-50(106)28-20-46)74(118)98-56(14-8-34-92-78(85)86)68(112)102-60(38-44(3)4)72(116)96-58(16-10-36-94-80(89)90)70(114)104-64(76(121)122)42-48-23-31-52(108)32-24-48/h17-32,43-44,53-64,105-108H,5-16,33-42,81-82H2,1-4H3,(H,95,115)(H,96,116)(H,97,117)(H,98,118)(H,99,109)(H,100,110)(H,101,111)(H,102,112)(H,103,113)(H,104,114)(H,119,120)(H,121,122)(H4,83,84,91)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94)/t53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1
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InChIKey
FPKKOJOGVASCPV-ODXRWUIZSA-N
Physicochemical Property
logP
-3.6816
Rotatable Bonds
55
Heavy Atom Count
122
Polar Areas
756.16
Hydrogen Bond Donor Count
26
Hydrogen Bond Acceptor Count
22
Complexity
122

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73354703
ChEMBL ID
CHEMBL2371908
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02259, Neuropeptide Y receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 240 nM
   TI
   LI
   LO
   TS
2
Ki = 7.5 nM
   TI
   LI
   LO
   TS
Protein ID: PT01611, Neuropeptide Y receptor type 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 890 nM
   TI
   LI
   LO
   TS
Protein ID: PT01909, Neuropeptide Y receptor type 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 14.8 nM
   TI
   LI
   LO
   TS
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.05 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Sub[-Tyr-Arg-Leu-Arg-Tyr-NH2]2 )
Drug Name Sub[-Tyr-Arg-Leu-Arg-Tyr-NH2]2
Target(s)
Neuropeptide Y receptor type 4 (NPY4R)
Inhibitor
Neuropeptide Y receptor type 2 (NPY2R)
Inhibitor
Neuropeptide Y receptor type 1 (NPY1R)
Inhibitor